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United States

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Cat. No.: HY-163861

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Tl45b

Tl45b is an AChE inhibitor, with an IC₅₀ of 0.71 μM. Tl45b can be used for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₇F₆N₇OS
Molecular Weight:541.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Tl45b Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Tl45b is an AChE inhibitor, with an IC₅₀ of 0.71 μM. Tl45b can be used for the research of Alzheimer’s disease^[1].

All Cholinesterase (ChE) Isoforms :

AChE
BChE

Chemical Information

Molecular Weight 541.47
Formula C₂₂H₁₇F₆N₇OS
SMILES

FC(F)(F)C1=CC(C2=CN(CC(NC3=NC4=CC=C(N(CC)NC5)C5=C4S3)=O)N=N2)=CC(C(F)(F)F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fatima Ezzahra Laghchioua, et al. Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights. ACS Chem Neurosci. 2024 Jul 22. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Tl45b

All Cholinesterase (ChE) Isoforms