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Cat. No.: HY-150545

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AChE-IN-21

AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC₅₀ of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro.

For research use only. We do not sell to patients.

CAS No.: 2413656-04-7
Formula: C₂₄H₂₉NO₄
Molecular Weight:395.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AChE-IN-21 Chemical Structure

CAS No.: 2413656-04-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC₅₀ of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro^[1].

IC₅₀ & Target

EeAChE

2.66 nM (IC₅₀)

RatBuChE

19.10 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

AChE-IN-21 (Compound I-8) binds to both the catalytic active site and peripheral anionic site of AChE^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.; once a day for 7 consecutive days) significantly reverses scopolamine-induced memory deficit in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming mice at body weight of 18–22 g (male and female in half)^[1]
Dosage:

1.0, 5.0 and 25.0 mg/kg
Administration:

Intragastric administration, once a day for 7 consecutive days
Result:

Obviously blocked scopolamine (2 mg/kg, i.p.)-induced memory deficit.

Chemical Information

CAS No. 2413656-04-7
Molecular Weight 395.49
Formula C₂₄H₂₉NO₄
SMILES

O=C1O/C(C2=C1C=C(OC)C(OC)=C2)=C\CCCCCN(CC3=CC=CC=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Luo L, et al. Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease. Bioorg Med Chem. 2020 Apr 15;28(8):115400. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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AChE-IN-21

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AChE-IN-21 Related Classifications

HY-150545 Related Classifications