2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE-IN-21

AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro.

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AChE-IN-21 Chemical Structure

AChE-IN-21 Chemical Structure

CAS No. : 2413656-04-7

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AChE-IN-21 Related Antibodies

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Description

AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro[1].

IC50 & Target

EeAChE

2.66 nM (IC50)

RatBuChE

19.10 μM (IC50)

In Vitro

AChE-IN-21 (Compound I-8) binds to both the catalytic active site and peripheral anionic site of AChE[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-21 Related Antibodies
In Vivo

AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.; once a day for 7 consecutive days) significantly reverses scopolamine-induced memory deficit in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice at body weight of 18–22 g (male and female in half)[1]
Dosage: 1.0, 5.0 and 25.0 mg/kg
Administration: Intragastric administration, once a day for 7 consecutive days
Result: Obviously blocked scopolamine (2 mg/kg, i.p.)-induced memory deficit.
Molecular Weight

395.49

Formula

C24H29NO4
CAS No.
SMILES

O=C1O/C(C2=C1C=C(OC)C(OC)=C2)=C\CCCCCN(CC3=CC=CC=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AChE-IN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-212413656-04-7Cholinesterase (ChE)Alzheimer’s diseaseBBB permeabilityKunming miceorally activeInhibitorinhibitorinhibit

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