1. Neuronal Signaling
    Stem Cell/Wnt
    PI3K/Akt/mTOR
  2. AChE
    GSK-3
  3. ZLWH-23

ZLWH-23 

Cat. No.: HY-144316
Handling Instructions

ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

ZLWH-23 Chemical Structure

ZLWH-23 Chemical Structure

CAS No. : 2765251-12-3

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Description

ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease[1].

IC50 & Target[1]

GSK-3β

6.78 μM (IC50)

AChE

0.27 μM (IC50)

In Vitro

ZLWH-23 exhibits good selectivity for GSK-3β over multi-kinases and very low cytotoxicity towards SH-SY5Y, HEK-293T, HL-7702, and HepG2 cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ZLWH-23 displays efficient reduction against tau hyperphosphorylation on Ser-396 site in Tau (P301L) 293T cell model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

513.61

Formula

C30H32FN5O2

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
ZLWH-23
Cat. No.:
HY-144316
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