2765251-12-3
Chemical Structure
ZLWH-23
- CAS No.: 2765251-12-3
- Formula:C30H32FN5O2
- Molecular Weight:513.61
IUPAC Name: 1-(cyclopropanecarboxamido)-N-(2-(1-(2-fluorobenzyl)piperidin-4-yl)ethyl)-9H-pyrido[3,4-b]indole-7-carboxamide
InChIKey: AMLAWNFGPZNOOW-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(C3=CC=NC(NC(C4CC4)=O)=C3N2)C=C1)NCCC5CCN(CC5)CC6=C(C=CC=C6)F
Biological Activity: ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease[1].
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ZLWH-23 | ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease. | |||||||||||||||||||||
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Keywords
