2. Others Neuronal Signaling
  3. Drug Derivative Cholinesterase (ChE)
  4. Stacofylline

Stacofylline  (Synonyms: S 9977 free base; S 9977-2 free base)

Cat. No.: HY-106412
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Stacofylline (S 9977 free base; S 9977-2 free base), a Xanthine (HY-W017389) derivative, is a potent AChE inhibitor with an IC50 of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities.

For research use only. We do not sell to patients.

Stacofylline

Stacofylline Chemical Structure

CAS No. : 98833-92-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Stacofylline:

Stacofylline Related Antibodies

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Description

Stacofylline (S 9977 free base; S 9977-2 free base), a Xanthine (HY-W017389) derivative, is a potent AChE inhibitor with an IC50 of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities[1][2].

IC50 & Target[1]

AChE

5-50 nM (IC50)

In Vitro

Stacofylline potentiates cholinergic transmission by significantly increasing the time constant of decay (Tc) of inhibitory postsynaptic currents (IPSCs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Stacofylline Related Antibodies
In Vivo

Stacofylline (0.0312-0.5 mg/kg; p.o.) clearly attenuates the memory deficits induced by the three amnesic treatments after acute treatment in Scopolamine, Diazepam, and electroconvulsive shock (ECS) mouse models,[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

419.52

Formula

C20H33N7O3
CAS No.
SMILES

CN1C2=C(N(C(N(C)C2=O)=O)C)N=C1CCCN3CCN(C(N(CC)CC)=O)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Stacofylline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stacofylline98833-92-2S 9977S 9977-2S9977S-9977Drug DerivativeCholinesterase (ChE)Drug derivativeAChE Inhibitoranti-amnesicInhibitorinhibitorinhibit

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