98833-92-2
98833-92-2
Chemical Structure
Stacofylline
Synonym(s): S 9977 free base; S 9977-2 free base
- CAS No.: 98833-92-2
- Formula:C20H33N7O3
- Molecular Weight:419.52
IUPAC Name: N,N-diethyl-4-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propyl)piperazine-1-carboxamide
InChIKey: PKXWXHGLEXOSQK-UHFFFAOYSA-N
SMILES: CN1C2=C(N(C(N(C)C2=O)=O)C)N=C1CCCN3CCN(C(N(CC)CC)=O)CC3
Biological Activity: Stacofylline (S 9977 free base; S 9977-2 free base), a Xanthine (HY-W017389) derivative, is a potent AChE inhibitor with an IC50 of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities[1][2].
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Stacofylline | Stacofylline (S 9977 free base; S 9977-2 free base), a Xanthine (HY-W017389) derivative, is a potent AChE inhibitor with an IC50 of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities. | |||||||||||||||||||||
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References
- [1]. L E Trudeau, et al. Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain Res. 1992 Jul 17;586(1):78-85. [Content Brief]
- [2]. Roger D. Porsolt, et al. Potential cognition-enhancing properties of S 9977 in three moenls of amnesia in the mouse. Drug Development Research. 1992.
Keywords
