1,1'-Bi-2-naphthol

Cat. No.: HY-W017765: Data Sheet
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2,2'-Dihydroxy-1,1'-binaphthyl is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 21.9 μM against human AChE. 2,2'-Dihydroxy-1,1'-binaphthyl exhibits cytotoxicity against Artemia nauplii.

For research use only. We do not sell to patients.

1,1'-Bi-2-naphthol Chemical Structure

CAS No. : 602-09-5

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Description

IC₅₀ & Target^[1]

hAChE

21.9 μM (IC₅₀)

In Vivo

1,1'-Bi-2-naphthol (Compound 2) (10-80 μg/mL, 24 h) exhibits significant cytotoxicity against Artemia nauplii, with an LD₅₀ value of 17.78 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Artemia salina^[1]
Dosage:	10, 20, 40, 60, 80 μg/mL
Administration:	single dose; 24 h
Result:	Calculated an LD₅₀ value of 17.78 μg/mL.

Molecular Weight

286.33

Formula

C₂₀H₁₄O₂

CAS No.

602-09-5

Appearance

Solid

Color

White to off-white

SMILES

OC=1C=CC=2C=CC=CC2C1C3=C(O)C=CC=4C=CC=CC43

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation

Purity: 99.94%

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Data Sheet (278 KB) SDS (480 KB)

COA (262 KB) HNMR (130 KB) RP-HPLC (256 KB)

Handling Instructions (2659 KB)

References

[1]. Parveen M, et al. Acetylcholinesterase and Cytotoxic Activity of Chemical Constituents of Clutia lanceolata Leaves and its Molecular Docking Study. Nat Prod Bioprospect. 2016;6(6):267-278. [Content Brief]

1,1'-Bi-2-naphthol Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,1'-Bi-2-naphthol602-09-5Cholinesterase (ChE)AChEbrine shrimp naupliiInhibitorinhibitorinhibit

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