1. Neuronal Signaling
  2. AChE
  3. Galanthaminone

Galanthaminone (Synonyms: (-)-Narwedine; Narwedin)

Cat. No.: HY-I0020 Purity: 99.55%
Handling Instructions

Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

For research use only. We do not sell to patients.

Galanthaminone Chemical Structure

Galanthaminone Chemical Structure

CAS No. : 510-77-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 172 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 156 In-stock
Estimated Time of Arrival: December 31
10 mg USD 252 In-stock
Estimated Time of Arrival: December 31
25 mg USD 600 In-stock
Estimated Time of Arrival: December 31
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Description

Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

IC50 & Target

AChE

In Vitro

Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Absorption of Galanthaminone is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

285.34

Formula

C₁₇H₁₉NO₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (35.05 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5046 mL 17.5230 mL 35.0459 mL
5 mM 0.7009 mL 3.5046 mL 7.0092 mL
10 mM 0.3505 mL 1.7523 mL 3.5046 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (3.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (3.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (3.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Galanthaminone
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HY-I0020
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