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Art. -Nr.: HY-182333

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AChE-IN-112

AChE-IN-112 is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 0.41 μM. AChE-IN-112 scavenges various reactive oxygen and reactive nitrogen species, including DPPH, ABTS, NO, hydroxyl and hydrogen peroxide free radicals. AChE-IN-112 can be used for the research of Alzheimer's disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₇H₂₈N₄O₇S
Molecular Weight:552.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AChE-IN-112 Chemical Structure

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

AChE

0.41 μM (IC₅₀)

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

In Vitro

AChE-IN-112 (Compound 4r) (62.5 µg/mL) shows weak inhibition of BChE, with 32.51% inhibition at a concentration of 62.5 µg/mL^[1].
AChE-IN-112 (10 μg/mL) possesses notable in vitro antioxidant activity, with a total antioxidant capacity of 66.80 mg gallic acid/g, an IRP level of 96.7 µM, and potent radical scavenging activity against DPPH, ABTS, NO, OH, and H₂O₂ radicals^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 552.60
Formel C₂₇H₂₈N₄O₇S
SMILES

CCCS(=O)(OC1=CC(/C=N/NC(COC2=CC=C(C3=NC4=CC=CC=C4N3)C=C2OC)=O)=CC=C1OC)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Animals and Diseases

Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Omar MA, et al. New benzimidazole-alkanesulfonate conjugates as cholinesterase inhibitors with in vitro and in silico validation. Sci Rep. 2026;16(1):8946. Published 2026 Mar 12. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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