AChE-IN-82
AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, COX-2 and 5-LOX with IC50s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H2 O2.
For research use only. We do not sell to patients.
- Formula: C21H18N4O5S2
- Molecular Weight:470.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
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EeAChE 0.072 μM (IC50) |
eqBCHE 9.81 μM (IC50) |
hMAO-A 14.52 μM (IC50) |
hMAO-B 0.024 μM (IC50) |
BACE1 2.42 μM (IC50) |
COX-1 60.41 μM (IC50) |
COX-2 0.187 μM (IC50) |
Chemical Information
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Molecular Weight 470.52
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Formula C21H18N4O5S2
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SMILES
COC1=C(O)C=CC(/C=C/C(NC2=CC(N=C(NCN3C(SCC3=O)=O)S4)=C4C=C2)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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