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sulfonamide

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1218
    Sulfaphenazole
    10+ Cited Publications

    Cytochrome P450 Antibiotic Bacterial Necroptosis Apoptosis Infection Cardiovascular Disease
    Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion .
    Sulfaphenazole
  • HY-14571
    E7820
    5 Publications Verification

    ER68203-00

    Molecular Glues Integrin Infection Metabolic Disease Cancer
    E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) .
    E7820
  • HY-107321
    Azosemide
    3 Publications Verification

    NKCC Metabolic Disease
    Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC50s of 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B, respectively .
    Azosemide
  • HY-B0507
    Sulfathiazole
    5+ Cited Publications

    Environmental Pollutants Antibiotic Bacterial Endocrinology Cancer
    Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish .
    Sulfathiazole
  • HY-B0921
    Succinylsulfathiazole
    1 Publications Verification

    Succinylsulphathiazole

    Antibiotic Bacterial Dihydrofolate reductase (DHFR) mTOR Infection
    Succinylsulfathiazole (Succinylsulphathiazole) is a long-acting sulfonamide antibiotic with localized gut-specific antibacterial activity and is orally active. Succinylsulfathiazole inhibits bacterial folate synthesis, reduces coliform counts, suppresses intestinal bacterial growth and vitamin biosynthesis, and depletes gut folate-producing bacteria. Succinylsulfathiazole modulates hepatic mTOR signaling, diminishes cecal fermentation, decreases hepatic folate levels and total folate excretion, elevates nitrogen excretion and reduces the fermentability of certain dietary fibers. Succinylsulfathiazole induces folate deficiency and triggers biotin- and folate-related nutritional deficiency symptoms in rats and C57BL/6 mice .
    Succinylsulfathiazole
  • HY-B0273
    Sulfadiazine
    5+ Cited Publications

    Antibiotic Bacterial Parasite Infection
    Sulfadiazine is an orally active sulfonamide antibiotic. Sulfadiazine competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine targets Toxoplasma gondii DHPS enzyme. Sulfadiazine can be used for the research of congenital toxoplasmosis and bacterial infection .
    Sulfadiazine
  • HY-B0322S
    Sulfamethoxazole-d4
    1 Publications Verification

    Ro 4-2130-d4

    Isotope-Labeled Compounds Antibiotic Bacterial Infection
    Sulfamethoxazole-d4 (Ro 4-2130-d4) is a deuterium labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .
    Sulfamethoxazole-d4
  • HY-B1267
    Sulfaguanidine
    2 Publications Verification

    Bacterial Antibiotic Infection
    Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery .
    Sulfaguanidine
  • HY-B0035
    Sulfamethazine
    3 Publications Verification

    Sulfadimidine; Sulfadimerazine

    Antibiotic Bacterial Infection Neurological Disease
    Sulfamethazine (Sulfadimidine) is a brain-penetrant sulfonamide antibiotic. Sulfamethazine inhibits bacterial growth by blocking the synthesis of folic acid. Sulfamethazine can be used for research on bacterial infections .
    Sulfamethazine
  • HY-B0273A
    Sulfadiazine sodium
    5+ Cited Publications

    Bacterial Parasite Antibiotic Infection
    Sulfadiazine sodium is an orally active sulfonamide antibiotic. Sulfadiazine sodium competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine sodium persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine sodium targets Toxoplasma gondii DHPS enzyme. Sulfadiazine sodium can be used for the research of congenital toxoplasmosis and bacterial infection .
    Sulfadiazine sodium
  • HY-B0946
    Sulfamonomethoxine
    1 Publications Verification

    Antibiotic Bacterial Infection
    Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .
    Sulfamonomethoxine
  • HY-139081

    Sodium Channel Neurological Disease
    GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7 .
    GDC-0310
  • HY-B1781
    Sulfachloropyridazine
    2 Publications Verification

    Sulfachlorpyridazine

    Bacterial Antibiotic Infection
    Sulfachloropyridazine is a broad spectrum sulfonamide that can be used against both gram-positive and gram-negative aerobic bacteria as well as Chlamydia. Sulfachloropyridazine is also considered as a common pollutant in surface and groundwater. Sulfachloropyridazine via electro-Fenton is a model for sulfonamide antibiotics that are widespread in waters .
    Sulfachloropyridazine
  • HY-B1784

    Sulfaisodimidine

    Bacterial Antibiotic Infection
    Sulfisomidin (Sulfaisodimidine) is an orally active short-acting sulfonamide antibacterial. Sulfisomidin can be used for the research of lower urinary tract infections .
    Sulfisomidin
  • HY-106662

    Chloroquinoxaline; NSC-339004

    Molecular Glues Topoisomerase Parasite Infection Cancer
    Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle . Antitumor activity .
    Chloroquinoxaline sulfonamide
  • HY-W074975

    5-Amino-1,3,4-thiadiazole-2-sulfonamide

    Carbonic Anhydrase Cancer
    CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is a selective inhibitor of carbonic anhydrase B (HCA-B) and isoforms I, II, IV, and VII. CL 5343 has a Ki of 7.9 nM for hCA II. CL 5343 acts as a CA9 ligand to achieve targeted delivery of maytansine to the cell membrane of SKRC52 renal cancer cells. CL 5343 is useful in the development of therapeutics for diseases associated with CA overactivity, such as glaucoma, epilepsy, and cancer .
    CL 5343
  • HY-B1386

    Environmental Pollutants Bacterial Sodium Channel Carbonic Anhydrase Infection
    Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 μM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water .
    Halazone
  • HY-W033049

    DABSO

    Biochemical Assay Reagents Others
    DABCO-Bis(sulfur dioxide) (DABSO) is a source of sulfur dioxide in organic synthesis and can be used in the preparation of sulfonamides and sulfonamides .
    DABCO-Bis(sulfur dioxide)
  • HY-120553
    B-355252
    1 Publications Verification

    Apoptosis Neurological Disease
    B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD) .
    B-355252
  • HY-108425B

    (Rac)-AMG8380

    Sodium Channel Neurological Disease
    (Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively .
    (Rac)-AMG8379
  • HY-B0322S1

    Ro 4-2130-13C6

    Isotope-Labeled Compounds Antibiotic Bacterial Infection
    Sulfamethoxazole- 13C6 (Ro 4-2130- 13C6) is a 13C labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .
    Sulfamethoxazole-13C6
  • HY-B0576
    Sulfacetamide sodium
    3 Publications Verification

    Sulphacetamide sodium

    Antibiotic Bacterial Fungal Infection Inflammation/Immunology
    Sulfacetamide (Sulphacetamide) sodium is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide sodium has antifungal and antibacterial activities .
    Sulfacetamide sodium
  • HY-B1236
    Sulfacarbamide
    2 Publications Verification

    Sulfanilylurea; Urosulfan

    Bacterial Infection Metabolic Disease
    Sulfacarbamide (Sulfanilylurea, Urosulfan) is an orally active class of sulfonamides with an antimicrobial activity. Sulfacarbamide can be used for the study of diabetes .
    Sulfacarbamide
  • HY-U00131

    N 3517; Sulfabromomethazine

    Bacterial Infection
    Sulfabrom (N 3517; Sulfabromomethazine) is a long-acting Sulfonamide that is used for the treatment of coccidiosis and various bacterial infections in the poultry, swine and cattle.
    Sulfabrom
  • HY-W587805

    FHxSA

    Carbonic Anhydrase Others
    Perfluorohexane sulfonamide (FHxSA) is the inhibitor for carbonic anhydrase, that inhibits bovine CA and human CA II with IC50 of 0.122 and 1.38 μM. Perfluorohexane sulfonamide is a delayed-action insecticide, that can be used to control red fire ants (Solenopsis invicta). Perfluorohexane sulfonamide could be a environmental pollutant .
    Perfluorohexane sulfonamide
  • HY-W041324

    Drug Intermediate Infection
    Glimepiride sulfonamide is a intermediate, and can be used to synthesize Glimepiride (HY-B0104) (antidiabetic agent) .
    Glimepiride sulfonamide
  • HY-16472

    Antibiotic Bacterial Infection
    Sulfacytine is a short-acting sulfonamide antibiotic. Sulfacytine is active against bacteria and is an effective agent for the research of acute uncomplicated urinary tract infections .
    Sulfacytine
  • HY-B0273S

    Bacterial Infection
    Sulfadiazine-d4 is a deuterium labeled Sulfadiazine (HY-B0273). Sulfadiazine is an orally active sulfonamide antibiotic. Sulfadiazine competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine targets Toxoplasma gondii DHPS enzyme. Sulfadiazine can be used for the research of congenital toxoplasmosis and bacterial infection .
    Sulfadiazine-d4
  • HY-W587780

    SMX-NO

    Biochemical Assay Reagents Inflammation/Immunology
    Sulfamethoxazole-NO (SMX-NO) is the major immunogen in sulfonamide allergy, producing modest ascorbic acid depletion and hemoglobin adduct formation. Sulfamethoxazole-NO haptens tissue proteins and is immunogenic in rodents .
    Sulfamethoxazole-NO
  • HY-69077

    Drug Intermediate Infection
    5-Bromo-1H-pyrazolo[3,4-b]pyridine is a drug intermediate that can be used for the synthesis of sulfonamide derivatives.
    5-Bromo-1H-pyrazolo[3,4-b]pyridine
  • HY-108425

    Sodium Channel Neurological Disease
    AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM .
    AMG8379
  • HY-B0888
    Sulfacetamide sodium monohydrate
    3 Publications Verification

    Sulphacetamide sodium monohydrate

    Antibiotic Bacterial Fungal Infection Inflammation/Immunology
    Sulfacetamide (Sulphacetamide) sodium monohydrate is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide sodium monohydrate has antifungal and antibacterial activities .
    Sulfacetamide sodium monohydrate
  • HY-B0212S

    Isotope-Labeled Compounds Bacterial Infection
    Sulfapyridine-d4 a deuterium labeled Sulfapyridine. Sulfapyridine is a sulfonamide antibacterial .
    Sulfapyridine-d4
  • HY-B0273R

    Reference Standards Bacterial Parasite Antibiotic Infection
    Sulfadiazine (Standard) is the analytical standard of Sulfadiazine (HY-B0273). This product is intended for research and analytical applications. Sulfadiazine is an orally active sulfonamide antibiotic. Sulfadiazine competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine targets Toxoplasma gondii DHPS enzyme. Sulfadiazine can be used for the research of congenital toxoplasmosis and bacterial infection .
    Sulfadiazine (Standard)
  • HY-177331

    Integrin Cardiovascular Disease
    BTT-3034, a sulfonamide derivative, is an α2β1 integrin inhibitor. BTT-3034 inhibits cell adhesion to rat tail collagen I with an EC50 of 160 nM and a corresponding Emaxof 86%. BTT-3034 inhibits collagen binding by an α2 variant carrying the conformationally activating E318W mutation .
    BTT-3034
  • HY-B1267R

    Reference Standards Bacterial Antibiotic Infection
    Sulfaguanidine (Standard) is the analytical standard of Sulfaguanidine. This product is intended for research and analytical applications. Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery .
    Sulfaguanidine (Standard)
  • HY-148431

    Bacterial Infection
    Antimicrobial agent-14, a benzyl thiophene sulfonamide derivative is an antimicrobial agent, with a MIC of 200 μM against Campylobacter coli ATCC33559. Antimicrobial agent-14 can be used for the research of bacterial foodborne gastroenteritis .
    Antimicrobial agent-14
  • HY-B0946S

    Isotope-Labeled Compounds Antibiotic Bacterial Infection
    Sulfamonomethoxine-d4 is a deuterium labeled Sulfamonomethoxine (HY-B0946). Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .
    Sulfamonomethoxine-d4
  • HY-106570

    Potassium Channel Metabolic Disease
    Tripamide is an orally active sulfonamide-derived diuretic antihypertensive agent .
    Tripamide
  • HY-204927

    1-Methyl-N-(4-(piperidin-1-yl)phenyl)-1H-imidazole-4-sulfonamide
  • HY-B0323C

    Sulfafurazole 100 µg/mL in methanol

    Bacterial Biochemical Assay Reagents Infection
    Sulfisoxazole 100 μg/mL in methanol (Sulfafurazole 100 μg/mL in methanol) is a sulfonamide antimicrobial compound.
    Sulfisoxazole 100 µg/mL in methanol
  • HY-B1781R

    Sulfachlorpyridazine (Standard)

    Reference Standards Bacterial Antibiotic Infection
    Sulfachloropyridazine (Standard) is the analytical standard of Sulfachloropyridazine. This product is intended for research and analytical applications. Sulfachloropyridazine is a broad spectrum sulfonamide that can be used against both gram-positive and gram-negative aerobic bacteria as well as Chlamydia. Sulfachloropyridazine is also considered as a common pollutant in surface and groundwater. Sulfachloropyridazine via electro-Fenton is a model for sulfonamide antibiotics that are widespread in waters .
    Sulfachloropyridazine (Standard)
  • HY-Y0544S

    Isotope-Labeled Compounds Others
    N-Methyl-N-nitrosotoluene-4-sulfonamide-d3 is the deuterium labeled N-Methyl-N-nitrosotoluene-4-sulfonamide .
    N-Methyl-N-nitrosotoluene-4-sulfonamide-d3
  • HY-204927A

    Drug Intermediate Others
    1-Methyl-N-(4-(piperidin-1-yl)phenyl)-1H-imidazole-4-sulfonamide TFA is a pharmaceutical synthesis intermediate.
    1-Methyl-N-(4-(piperidin-1-yl)phenyl)-1H-imidazole-4-sulfonamide TFA
  • HY-112586

    Bacterial Antibiotic Infection
    Sulfaethoxypyridazine is a sulfonamide antibacterial agent. Sulfaethoxypyridazine is a sulfonamide that is used in veterinary medicine as feedstuffs .
    Sulfaethoxypyridazine
  • HY-101829

    Sulfaproxylin; Sulfaproxyline

    Antibiotic Bacterial Infection
    Sulfaproxyline (Sulfaproxylin; Sulfaproxyline) is a sulfonamide antibiotic that inhibits bacterial dihydropteroate synthase, thereby blocking folate biosynthesis required for nucleic acid production. Sulfaproxyline shows antimicrobial activity primarily against Staphylococcus species and common uropathogens. Sulfaproxyline reduces bacterial growth by impairing DNA and protein synthesis. Sulfaproxyline can be used for research of staphylococcal and urinary tract infections .
    Sulfaproxiline
  • HY-B1218R

    Reference Standards Cytochrome P450 Antibiotic Bacterial Necroptosis Apoptosis Infection Cardiovascular Disease
    Sulfaphenazole (Standard) is the analytical standard of Sulfaphenazole. This product is intended for research and analytical applications. Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion .
    Sulfaphenazole (Standard)
  • HY-B1781A

    Sulfachlorpyridazine sodium

    Bacterial Antibiotic Infection
    Sulfachloropyridazine (sodium) is a sulfonamide antibiotic that inhibits bacterial growth .
    Sulfachloropyridazine sodium
  • HY-121214

    Environmental Pollutants Apoptosis Fungal Reactive Oxygen Species (ROS) Mitochondrial Metabolism Infection Cardiovascular Disease
    Amisulbrom is a sulfonamide fungicide used to control oomycete diseases. Amisulbrom inhibits the cytochrome-bc1 complex of the mitochondrial electron transport system.
    Amisulbrom
  • HY-160094

    Ligands for Target Protein for PROTAC Cancer
    BCN-sulfonamide-PEG2-sulfonamide-N-bis ethanol (compound 71) is a Ligands for Target Protein for PROTAC that contains a sulfonamide linker to increase the solubility of the linker-conjugate. BCN-sulfonamide-PEG2-sulfonamide-N-bis ethanol can be used to synthesize PROTACs with antitumor activity .
    BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol)

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