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Cat. No.: HY-120676

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B-Raf IN 18

B-Raf IN 18 (compound 26) is a B-Raf inhibitor, with IC₅₀ of 3.8 nM. B-Raf IN 18 can be used in anti-cancer related research.

For research use only. We do not sell to patients.

CAS No.: 1244644-50-5
Formula: C₃₁H₂₈F₃N₇O₃S₂
Molecular Weight:667.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

B-Raf IN 18 Chemical Structure

CAS No.: 1244644-50-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

B-Raf IN 18 (compound 26) is a B-Raf inhibitor, with IC₅₀ of 3.8 nM. B-Raf IN 18 can be used in anti-cancer related research^[1].

IC₅₀ & Target

B-Raf^V600E

3.8 nM (IC₅₀)

All Raf Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-MEL-28	EC₅₀	11 nM Compound: 24	Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as reduction of ERK phosphorylation after 1 hr Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as reduction of ERK phosphorylation after 1 hr	[PMID: 21733693]
SK-MEL-28	EC₅₀	8 nM Compound: 24	Antiproliferative activity against human SK-MEL-28 cells expressing B-Raf V600E mutant after 3 days by CellTiter-Glo assay Antiproliferative activity against human SK-MEL-28 cells expressing B-Raf V600E mutant after 3 days by CellTiter-Glo assay	[PMID: 21733693]
SK-MEL-28	IC₅₀	23 nM Compound: 1	Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as decrease in ERK phosphorylation incubated for 1 hr by immunoassay Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as decrease in ERK phosphorylation incubated for 1 hr by immunoassay	[PMID: 24900673]
SK-MEL-28	IC₅₀	48 nM Compound: 1	Inhibition of B-Raf V600E mutant-driven SK-MEL-28 cell proliferation after 72 hrs by CellTiter-Glo luminescent assay Inhibition of B-Raf V600E mutant-driven SK-MEL-28 cell proliferation after 72 hrs by CellTiter-Glo luminescent assay	[PMID: 24900673]

Chemical Information

CAS No. 1244644-50-5
Molecular Weight 667.72
Formula C₃₁H₂₈F₃N₇O₃S₂
SMILES

O=S(C1=C(C=CC=C1F)F)(NC2=CC=CC(C3=C(SC(C(C)C)=N3)C4=NC(NC5=CC=C(N=C5)N6CCOCC6)=NC=C4)=C2F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Stellwagen JC,et al. Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4436-40. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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