B-Raf IN 18
B-Raf IN 18 (compound 26) is a B-Raf inhibitor, with IC50 of 3.8 nM. B-Raf IN 18 can be used in anti-cancer related research.
For research use only. We do not sell to patients.
- CAS No.: 1244644-50-5
- Formula: C31H28F3N7O3S2
- Molecular Weight:667.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
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B-RafV600E 3.8 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| SK-MEL-28 | EC50 |
11 nM
Compound: 24
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Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as reduction of ERK phosphorylation after 1 hr
Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as reduction of ERK phosphorylation after 1 hr
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[PMID: 21733693] |
| SK-MEL-28 | EC50 |
8 nM
Compound: 24
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Antiproliferative activity against human SK-MEL-28 cells expressing B-Raf V600E mutant after 3 days by CellTiter-Glo assay
Antiproliferative activity against human SK-MEL-28 cells expressing B-Raf V600E mutant after 3 days by CellTiter-Glo assay
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[PMID: 21733693] |
| SK-MEL-28 | IC50 |
23 nM
Compound: 1
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Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as decrease in ERK phosphorylation incubated for 1 hr by immunoassay
Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as decrease in ERK phosphorylation incubated for 1 hr by immunoassay
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[PMID: 24900673] |
| SK-MEL-28 | IC50 |
48 nM
Compound: 1
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Inhibition of B-Raf V600E mutant-driven SK-MEL-28 cell proliferation after 72 hrs by CellTiter-Glo luminescent assay
Inhibition of B-Raf V600E mutant-driven SK-MEL-28 cell proliferation after 72 hrs by CellTiter-Glo luminescent assay
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[PMID: 24900673] |
Chemical Information
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CAS No. 1244644-50-5
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Molecular Weight 667.72
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Formula C31H28F3N7O3S2
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SMILES
O=S(C1=C(C=CC=C1F)F)(NC2=CC=CC(C3=C(SC(C(C)C)=N3)C4=NC(NC5=CC=C(N=C5)N6CCOCC6)=NC=C4)=C2F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
B-Raf IN 18 Related Classifications
HY-120676 Related Classifications
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