DABCO-Bis(sulfur dioxide)
Based on 1 Customer Validation
DABCO-Bis (sulfur dioxide) (DABSO) is a sulfur dioxide donor and synthetic precursor. DABCO-Bis (sulfur dioxide) serves as a source of sulfur dioxide in organic synthesis, and finds application in the preparation of sulfonamides and sulfamides.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 119752-83-9
- Formula: C6H12N2O4S2
- Molecular Weight:240.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
DABCO-Bis (sulfur dioxide) (DABSO) acts as an SO2 surrogate in a palladium-catalyzed domino Heck/sulfination reaction to generate reactive sulfinate intermediates that can be converted to sulfones, sulfonamides, or sulfonyl fluorides, producing a broad range of sulfur-containing hetero- and carbocyclic scaffolds with isolated yields from 32% to 80%[2].
DABCO-Bis (sulfur dioxide) delivers sulfur dioxide as a sulfinyl-dication equivalent in a one-pot room-temperature reaction with organometallic reagents and trimethylsilyl chloride, generating a wide range of unsymmetrical sulfoxides in good to excellent isolated yields (47-99%) and high selectivity for the desired product[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 119752-83-9
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Appearance Solid
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Molecular Weight 240.31
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Formula C6H12N2O4S2
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Color White to off-white
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SMILES
O=S([N+]12CC[N+](CC2)(S([O-])=O)CC1)[O-]
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Synonyms
DABSO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL (416.13 mM)
DMSO : 1.96 mg/mL (8.16 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (605 KB)
- English - EN (605 KB)
- Français - FR (605 KB)
- Deutsch - DE (605 KB)
- Norwegian - NO (605 KB)
- Español - ES (605 KB)
- Swedish - SV (605 KB)
- Italian - IT (605 KB)
- Korean - KR (605 KB)
- Portuguese - PT (605 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.1613 mL | 20.8065 mL | 41.6129 mL | 104.0323 mL |
| 5 mM | 0.8323 mL | 4.1613 mL | 8.3226 mL | 20.8065 mL | |
| H2O | 10 mM | 0.4161 mL | 2.0806 mL | 4.1613 mL | 10.4032 mL |
| 15 mM | 0.2774 mL | 1.3871 mL | 2.7742 mL | 6.9355 mL | |
| 20 mM | 0.2081 mL | 1.0403 mL | 2.0806 mL | 5.2016 mL | |
| 25 mM | 0.1665 mL | 0.8323 mL | 1.6645 mL | 4.1613 mL | |
| 30 mM | 0.1387 mL | 0.6935 mL | 1.3871 mL | 3.4677 mL | |
| 40 mM | 0.1040 mL | 0.5202 mL | 1.0403 mL | 2.6008 mL | |
| 50 mM | 0.0832 mL | 0.4161 mL | 0.8323 mL | 2.0806 mL | |
| 60 mM | 0.0694 mL | 0.3468 mL | 0.6935 mL | 1.7339 mL | |
| 80 mM | 0.0520 mL | 0.2601 mL | 0.5202 mL | 1.3004 mL | |
| 100 mM | 0.0416 mL | 0.2081 mL | 0.4161 mL | 1.0403 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DABCO-Bis(sulfur dioxide) Related Classifications
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