Cat. No.: HY-B0337B

Sulfadimethoxine 1000 µg/mL in methanol

Name: Sulfadimethoxine 1000 µg/mL in methanol
Brand: MedChemExpress
SKU: HY-B0337B
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(Synonyms: Sulphadimethoxine 1000 µg/mL in methanol)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Sulfadimethoxine (Sulphadimethoxine) 1000 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadimethoxine 1000 µg/mL in methanol reduces Eimeria-related mortality, weight loss, and lesions. Sulfadimethoxine 1000 µg/mL in methanol can be used for the research of avian coccidiosis.

For research use only. We do not sell to patients.

CAS No.: 122-11-2
Formula: C₁₂H₁₄N₄O₄S
Molecular Weight:310.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

Sulfadimethoxine 1000 µg/mL in methanol Chemical Structure

CAS No.: 122-11-2

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

Coccidia

All Antibiotic Isoforms :

All Parasite Isoforms :

In Vitro

Sulfadimethoxine (50 µg/mL; 24 h) 1000 µg/mL in methanol exhibits extensive (87.5%) binding to plasma proteins from domestic short-haired cats when tested via equilibrium dialysis at 37°C^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) 1000 µg/mL in methanol administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria tenella-infected chicks, with 0.05% supporting the highest weight gain^[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) 1000 µg/mL in methanol administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria necatrix-infected chicks, while 0.025% is ineffective against this species^[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) 1000 µg/mL in methanol administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria acervulina-infected chicks, with 0.05% supporting weight gain equal to uninfected controls^[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) 1000 µg/mL in methanol administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria maxima-infected chicks, with all doses supporting similar weight gain^[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) 1000 µg/mL in methanol administered in drinking water starting 3 days post-infection provides complete mortality protection and eliminates pathological lesions in Eimeria brunetti-infected chicks^[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) 1000 µg/mL in methanol administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria mivati-infected chicks, with 0.05% supporting weight gain greater than uninfected controls^[1].
Sulfadimethoxine (0.05%; p.o.; daily; 6 days) 1000 µg/mL in methanol administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in chicks with mixed Eimeria infections^[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) 1000 µg/mL in methanol administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria gallopavonis-infected turkey poults, with 0.025% supporting weight gain greater than uninfected controls^[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) 1000 µg/mL in methanol administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria meleagrimitis-infected turkey poults^[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) 1000 µg/mL in methanol administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria adenoeides-infected turkey poults^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Peterson Cross (1 day old, grouped by weight and sex, 2 weeks old at test initiation)^[1]
Dosage:

0.025%; 0.05%; 0.1%
Administration:

p.o.; daily; 6 days
Result:

Achieved 0% mortality, 82% weight gain relative to uninfected unmedicated controls (UUC), and average degree of infection (ADI) of 0.3 at 0.1% dose in Eimeria tenella-infected chicks.
Achieved 0% mortality, 89% weight gain relative to UUC, and ADI of 0.8 at 0.05% dose in Eimeria tenella-infected chicks.
Achieved 0% mortality, 86% weight gain relative to UUC, and ADI of 1.6 at 0.025% dose in Eimeria tenella-infected chicks.
Achieved 0% mortality, 71% weight gain relative to UUC, and ADI of 0.7 at 0.1% dose in Eimeria necatrix-infected chicks.
Achieved 5% mortality, 60% weight gain relative to UUC, and ADI of 1.9 at 0.05% dose in Eimeria necatrix-infected chicks.
Achieved 50% mortality, 39% weight gain relative to UUC, and ADI of 3.4 at 0.025% dose in Eimeria necatrix-infected chicks.
Achieved 0% mortality, 86% weight gain relative to UUC, and ADI of 0.3 at 0.1% dose in Eimeria acervulina-infected chicks.
Achieved 0% mortality, 101% weight gain relative to UUC, and ADI of 0.3 at 0.05% dose in Eimeria acervulina-infected chicks.
Achieved 0% mortality, 92% weight gain relative to UUC, and ADI of 1.6 at 0.025% dose in Eimeria acervulina-infected chicks.
Achieved 0% mortality, 83% weight gain relative to UUC, and ADI of 0.5 at 0.1% dose in Eimeria maxima-infected chicks.
Achieved 0% mortality, 84% weight gain relative to UUC, and ADI of 0.2 at 0.05% dose in Eimeria maxima-infected chicks.
Achieved 0% mortality, 84% weight gain relative to UUC, and ADI of 0.4 at 0.025% dose in Eimeria maxima-infected chicks.
Achieved 0% mortality, 80% weight gain relative to UUC, and no detectable lesions at 0.1% dose in Eimeria brunetti-infected chicks.
Achieved 0% mortality, 92% weight gain relative to UUC, and no detectable lesions at 0.05% dose in Eimeria brunetti-infected chicks.
Achieved 0% mortality, 89% weight gain relative to UUC, and no detectable lesions at 0.025% dose in Eimeria brunetti-infected chicks.
Achieved 0% mortality, 86% weight gain relative to UUC, and ADI of 0.0 at 0.1% dose in Eimeria mivati-infected chicks.
Achieved 0% mortality, 101% weight gain relative to UUC, and ADI of 0.0 at 0.05% dose in Eimeria mivati-infected chicks.
Achieved 0% mortality, 102% weight gain relative to UUC, and ADI of 0.4 at 0.025% dose in Eimeria mivati-infected chicks.

Animal Model:

Peterson Cross (1 day old, grouped by weight and sex, 2 weeks old at test initiation)^[1]
Dosage:

0.05%
Administration:

p.o.; daily; 6 days
Result:

Achieved 0% mortality, 90% weight gain relative to UUC, and ADI of 0.3 in chicks with mixed Eimeria infections.

Animal Model:

Broad Breasted White (1 day old, grouped by weight and sex, 2 weeks old at test initiation)^[1]
Dosage:

0.0125%; 0.025%; 0.05%
Administration:

p.o.; daily; 6 days
Result:

Achieved 0% mortality, 94% weight gain relative to UUC, and ADI of 0.1 at 0.05% dose in Eimeria gallopavonis-infected turkey poults.
Achieved 0% mortality, 101% weight gain relative to UUC, and ADI of 0.0 at 0.025% dose in Eimeria gallopavonis-infected turkey poults.
Achieved 0% mortality, 89% weight gain relative to UUC, and ADI of 0.1 at 0.0125% dose in Eimeria gallopavonis-infected turkey poults.
Achieved 0% mortality, 77% weight gain relative to UUC, and ADI of 0.0 at 0.05% dose in Eimeria meleagrimitis-infected turkey poults.
Achieved 0% mortality, 78% weight gain relative to UUC, and ADI of 0.5 at 0.025% dose in Eimeria meleagrimitis-infected turkey poults.
Achieved 0% mortality, 79% weight gain relative to UUC, and ADI of 0.8 at 0.0125% dose in Eimeria meleagrimitis-infected turkey poults.
Achieved 0% mortality, 89% weight gain relative to UUC, and ADI of 0.0 at 0.05% dose in Eimeria adenoeides-infected turkey poults.
Achieved 0% mortality, 98% weight gain relative to UUC, and ADI of 0.0 at 0.025% dose in Eimeria adenoeides-infected turkey poults.
Achieved 0% mortality, 100% weight gain relative to UUC, and ADI of 0.1 at 0.0125% dose in Eimeria adenoeides-infected turkey poults.

Chemical Information

CAS No. 122-11-2
Molecular Weight 310.33
Formula C₁₂H₁₄N₄O₄S
SMILES

O=S(NC1=CC(OC)=NC(OC)=N1)(C2=CC=C(C=C2)N)=O
Synonyms

Sulphadimethoxine 1000 µg/mL in methanol
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Journal Impact Factor

ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Chemosphere

Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]

2019 Jun:225:378-387. PMID: 30884299

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mitrovic M, et al. Sulfadimethoxine Therapy of Avian Coccidiosis. Poult. Sci. 1967 Mar 1;46(2):402-411.

[2]. Białk-Bielińska A, et al. Sulfadimethoxine and sulfaguanidine: their sorption potential on natural soils. Chemosphere. 2012;86(10):1059-1065. [Content Brief]

[3]. Baggot JD. Pharmacokinetics of sulfadimethoxine in cats. Aust J Exp Biol Med Sci. 1977 Dec;55(6):663-70. [Content Brief]

[4]. Guerard JJ, et al. Photochemical fate of sulfadimethoxine in aquaculture waters. Environ Sci Technol. 2009;43(22):8587-8592. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Sulfadimethoxine 1000 µg/mL in methanol

3 Cited Publications

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Sulfadimethoxine 1000 µg/mL in methanol

Publications Citing Use of MedChemExpress (MCE) Sulfadimethoxine 1000 µg/mL in methanol

All Antibiotic Isoforms

All Parasite Isoforms