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  4. Sulfadimethoxine 1000 µg/mL in methanol

Sulfadimethoxine 1000 µg/mL in methanol  (Synonyms: Sulphadimethoxine 1000 µg/mL in methanol)

Cat. No.: HY-B0337B
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Sulfadimethoxine (Sulphadimethoxine) 1000 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadimethoxine 1000 µg/mL in methanol reduces Eimeria-related mortality, weight loss, and lesions. Sulfadimethoxine 1000 µg/mL in methanol can be used for the research of avian coccidiosis.

For research use only. We do not sell to patients.

Sulfadimethoxine 1000 µg/mL in methanol

Sulfadimethoxine 1000 µg/mL in methanol Chemical Structure

CAS No. : 122-11-2

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Based on 3 publication(s) in Google Scholar

Other Forms of Sulfadimethoxine 1000 µg/mL in methanol:

Sulfadimethoxine 1000 µg/mL in methanol Related Antibodies

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Description

Sulfadimethoxine (Sulphadimethoxine) 1000 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadimethoxine 1000 µg/mL in methanol reduces Eimeria-related mortality, weight loss, and lesions. Sulfadimethoxine 1000 µg/mL in methanol can be used for the research of avian coccidiosis[1].

IC50 & Target[1]

Coccidia

 

In Vitro

Sulfadimethoxine (50 µg/mL; 24 h) exhibits extensive (87.5%) binding to plasma proteins from domestic short-haired cats when tested via equilibrium dialysis at 37°C[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfadimethoxine 1000 µg/mL in methanol Related Antibodies
In Vivo

Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria tenella-infected chicks, with 0.05% supporting the highest weight gain[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria necatrix-infected chicks, while 0.025% is ineffective against this species[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria acervulina-infected chicks, with 0.05% supporting weight gain equal to uninfected controls[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria maxima-infected chicks, with all doses supporting similar weight gain[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and eliminates pathological lesions in Eimeria brunetti-infected chicks[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria mivati-infected chicks, with 0.05% supporting weight gain greater than uninfected controls[1].
Sulfadimethoxine (0.05%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in chicks with mixed Eimeria infections[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria gallopavonis-infected turkey poults, with 0.025% supporting weight gain greater than uninfected controls[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria meleagrimitis-infected turkey poults[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria adenoeides-infected turkey poults[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Peterson Cross (1 day old, grouped by weight and sex, 2 weeks old at test initiation)[1]
Dosage: 0.025%; 0.05%; 0.1%
Administration: p.o.; daily; 6 days
Result: Achieved 0% mortality, 82% weight gain relative to uninfected unmedicated controls (UUC), and average degree of infection (ADI) of 0.3 at 0.1% dose in Eimeria tenella-infected chicks.
Achieved 0% mortality, 89% weight gain relative to UUC, and ADI of 0.8 at 0.05% dose in Eimeria tenella-infected chicks.
Achieved 0% mortality, 86% weight gain relative to UUC, and ADI of 1.6 at 0.025% dose in Eimeria tenella-infected chicks.
Achieved 0% mortality, 71% weight gain relative to UUC, and ADI of 0.7 at 0.1% dose in Eimeria necatrix-infected chicks.
Achieved 5% mortality, 60% weight gain relative to UUC, and ADI of 1.9 at 0.05% dose in Eimeria necatrix-infected chicks.
Achieved 50% mortality, 39% weight gain relative to UUC, and ADI of 3.4 at 0.025% dose in Eimeria necatrix-infected chicks.
Achieved 0% mortality, 86% weight gain relative to UUC, and ADI of 0.3 at 0.1% dose in Eimeria acervulina-infected chicks.
Achieved 0% mortality, 101% weight gain relative to UUC, and ADI of 0.3 at 0.05% dose in Eimeria acervulina-infected chicks.
Achieved 0% mortality, 92% weight gain relative to UUC, and ADI of 1.6 at 0.025% dose in Eimeria acervulina-infected chicks.
Achieved 0% mortality, 83% weight gain relative to UUC, and ADI of 0.5 at 0.1% dose in Eimeria maxima-infected chicks.
Achieved 0% mortality, 84% weight gain relative to UUC, and ADI of 0.2 at 0.05% dose in Eimeria maxima-infected chicks.
Achieved 0% mortality, 84% weight gain relative to UUC, and ADI of 0.4 at 0.025% dose in Eimeria maxima-infected chicks.
Achieved 0% mortality, 80% weight gain relative to UUC, and no detectable lesions at 0.1% dose in Eimeria brunetti-infected chicks.
Achieved 0% mortality, 92% weight gain relative to UUC, and no detectable lesions at 0.05% dose in Eimeria brunetti-infected chicks.
Achieved 0% mortality, 89% weight gain relative to UUC, and no detectable lesions at 0.025% dose in Eimeria brunetti-infected chicks.
Achieved 0% mortality, 86% weight gain relative to UUC, and ADI of 0.0 at 0.1% dose in Eimeria mivati-infected chicks.
Achieved 0% mortality, 101% weight gain relative to UUC, and ADI of 0.0 at 0.05% dose in Eimeria mivati-infected chicks.
Achieved 0% mortality, 102% weight gain relative to UUC, and ADI of 0.4 at 0.025% dose in Eimeria mivati-infected chicks.
Animal Model: Peterson Cross (1 day old, grouped by weight and sex, 2 weeks old at test initiation)[1]
Dosage: 0.05%
Administration: p.o.; daily; 6 days
Result: Achieved 0% mortality, 90% weight gain relative to UUC, and ADI of 0.3 in chicks with mixed Eimeria infections.
Animal Model: Broad Breasted White (1 day old, grouped by weight and sex, 2 weeks old at test initiation)[1]
Dosage: 0.0125%; 0.025%; 0.05%
Administration: p.o.; daily; 6 days
Result: Achieved 0% mortality, 94% weight gain relative to UUC, and ADI of 0.1 at 0.05% dose in Eimeria gallopavonis-infected turkey poults.
Achieved 0% mortality, 101% weight gain relative to UUC, and ADI of 0.0 at 0.025% dose in Eimeria gallopavonis-infected turkey poults.
Achieved 0% mortality, 89% weight gain relative to UUC, and ADI of 0.1 at 0.0125% dose in Eimeria gallopavonis-infected turkey poults.
Achieved 0% mortality, 77% weight gain relative to UUC, and ADI of 0.0 at 0.05% dose in Eimeria meleagrimitis-infected turkey poults.
Achieved 0% mortality, 78% weight gain relative to UUC, and ADI of 0.5 at 0.025% dose in Eimeria meleagrimitis-infected turkey poults.
Achieved 0% mortality, 79% weight gain relative to UUC, and ADI of 0.8 at 0.0125% dose in Eimeria meleagrimitis-infected turkey poults.
Achieved 0% mortality, 89% weight gain relative to UUC, and ADI of 0.0 at 0.05% dose in Eimeria adenoeides-infected turkey poults.
Achieved 0% mortality, 98% weight gain relative to UUC, and ADI of 0.0 at 0.025% dose in Eimeria adenoeides-infected turkey poults.
Achieved 0% mortality, 100% weight gain relative to UUC, and ADI of 0.1 at 0.0125% dose in Eimeria adenoeides-infected turkey poults.
Molecular Weight

310.33

Formula

C12H14N4O4S
CAS No.
SMILES

O=S(NC1=CC(OC)=NC(OC)=N1)(C2=CC=C(C=C2)N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sulfadimethoxine 1000 µg/mL in methanol Related Classifications

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Keywords:

Sulfadimethoxine 1000 µg/mL in methanol122-11-2Sulphadimethoxine 1000 µg/mL in methanolAntibioticParasiteEnvironmental PollutantsEnvironmental ContaminantsEimeria gallopavonisEimeria tenellaEimeria maximaEimeria mivatiEimeria acervulinaEimeria necatrixEimeria meleagrimitisavian coccidiosisEimeria brunettiEimeria adenoeidesInhibitorinhibitorinhibit

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