1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. AMG8380

AMG8380 

Cat. No.: HY-108425A
Handling Instructions

AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM.

For research use only. We do not sell to patients.

AMG8380 Chemical Structure

AMG8380 Chemical Structure

CAS No. : 1642112-32-0

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Description

AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM[1].

In Vivo
Animal Model: C57Bl/6 male mice[1]
Dosage: 100 mg/kg
Administration: oral
Result: Failed to show a statistically significant effect on scratching behavior.
Molecular Weight

543.93

Formula

C₂₅H₁₆ClF₂N₃O₅S

CAS No.

1642112-32-0

SMILES

O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=CC(F)=C(C=C4OC)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O.[R]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AMG8380AMG 8380AMG-8380Sodium ChannelNa channelsNa+ channelsoralenantiomersulfonamidescratchingbehaviornociceptivepainitchInhibitorinhibitorinhibit

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AMG8380
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