2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. (Rac)-AMG8379

(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively .

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(Rac)-AMG8379 Chemical Structure

(Rac)-AMG8379 Chemical Structure

CAS No. : 1641574-26-6

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Based on 1 publication(s) in Google Scholar

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(Rac)-AMG8379 Related Antibodies

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Description

(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively [1].

IC50 & Target[1]

hNav1.7

8.5 nM (IC50)

mNav1.7

18.6 nM (IC50)

Molecular Weight

543.93

Formula

C25H16ClF2N3O5S
CAS No.
SMILES

O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=CC(F)=C(C=C4OC)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O.[Racemate]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(Rac)-AMG8379 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-AMG83791641574-26-6(Rac)-AMG8380Sodium ChannelNa channelsNa+ channelsracematedorsalrootgangliasulfonamideC-fibernociceptivepainitchInhibitorinhibitorinhibit

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