1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. (Rac)-AMG8379

(Rac)-AMG8379 (Synonyms: (Rac)-AMG8380)

Cat. No.: HY-108425B
Handling Instructions

(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively .

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(Rac)-AMG8379 Chemical Structure

(Rac)-AMG8379 Chemical Structure

CAS No. : 1641574-26-6

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Description

(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively [1].

Molecular Weight

543.93

Formula

C₂₅H₁₆ClF₂N₃O₅S

CAS No.

1641574-26-6

SMILES

O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=CC(F)=C(C=C4OC)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O.[Racemate]

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(Rac)-AMG8379(Rac)-AMG8380Sodium ChannelNa channelsNa+ channelsracematedorsalrootgangliasulfonamideC-fibernociceptivepainitchInhibitorinhibitorinhibit

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(Rac)-AMG8379
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