Azosemide (Standard)
Azosemide (Standard) is the analytical standard of Azosemide. This product is intended for research and analytical applications. Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC50s of 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B, respectively.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 27589-33-9
- Formula: C12H11ClN6O2S2
- Molecular Weight:370.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 27589-33-9
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Molecular Weight 370.84
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Formula C12H11ClN6O2S2
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SMILES
ClC1=CC(NCC2=CC=CS2)=C(C3=NN=NN3)C=C1S(N)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hampel P, et al. Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B. Sci Rep. 2018 Jun 29;8(1):9877. [Content Brief]
[2]. Kim EJ, et al. Pharmacokinetics and pharmacodynamics of intravenous azosemide in mutant Nagaseanalbuminemic rats. Drug Metab Dispos. 2003 Feb;31(2):194-201. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)