1. PI3K/Akt/mTOR
  2. PDK-1
  3. PDK1-IN-RS2

PDK1-IN-RS2 

Cat. No.: HY-114645
Handling Instructions

PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1.

For research use only. We do not sell to patients.

PDK1-IN-RS2 Chemical Structure

PDK1-IN-RS2 Chemical Structure

CAS No. : 1643958-89-7

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Description

PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1].

IC50 & Target

Kd: 9 μM (PDK1)[1]

In Vitro

PDK1-IN-RS2 stimulates the catalytic activity of PDK1 toward a peptide substrate by sixfold. The sulfonyl group of PDK1-IN-RS2 interacts with Arg131 through a salt bridge, because the sulfonamide is likely ionized under the crystallization conditions[1].

Molecular Weight

380.89

Formula

C₁₅H₉ClN₂O₂S₃

CAS No.

1643958-89-7

SMILES

O=S(C1=CC2=CC=CC=C2S1)(NC3=NC4=CC=C(C=C4S3)Cl)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PDK1-IN-RS2PDK-1Phosphoinositide dependent protein kinase-1S6K1catalyticsubstrateArg131PIFpocketLeu155sulfonyldiarylsulfonamideInhibitorinhibitorinhibit

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PDK1-IN-RS2
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