PDK1-IN-RS2
Based on 1 Customer Validation
PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.49%
- CAS No.: 1643958-89-7
- Formule: C15H9ClN2O2S3
- Masse moléculaire:380.89
-
Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-15967
PS48PDK1 Activator -
HY-14981
GSK2334470PDK1 Inhibitor -
HY-121629
PS210 -
HY-13856
(R)-PS210PDK1 Activator -
HY-13842
BX517PDK-1 Inhibitor -
HY-W837864
PDK1 allosteric modulator 1 -
HY-117809
PDK1-IN-2PDK1 Inhibitor -
HY-13851
PS47PDK1 Activator -
HY-14440
MP7PDK1 Inhibitor -
HY-10514
BX795PDK-1 Inhibitor -
HY-131962A
PKD-IN-1 dihydrochloridePDK-1 Inhibitor -
HY-10547
OSU-03012PDK-1 Inhibitor
Activité biologique
Description
IC50 & Target
Kd: 9 μM (PDK1)[1]
In Vitro
PDK1-IN-RS2 stimulates the catalytic activity of PDK1 toward a peptide substrate by sixfold. The sulfonyl group of PDK1-IN-RS2 interacts with Arg131 through a salt bridge, because the sulfonamide is likely ionized under the crystallization conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1643958-89-7
-
Appearance Solid
-
Masse moléculaire 380.89
-
Formule C15H9ClN2O2S3
-
Color White to light yellow
-
SMILES
O=S(C1=CC2=CC=CC=C2S1)(NC3=NC4=CC=C(C=C4S3)Cl)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (328.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (274 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6254 mL | 13.1271 mL | 26.2543 mL | 65.6357 mL |
| 5 mM | 0.5251 mL | 2.6254 mL | 5.2509 mL | 13.1271 mL | |
| 10 mM | 0.2625 mL | 1.3127 mL | 2.6254 mL | 6.5636 mL | |
| 15 mM | 0.1750 mL | 0.8751 mL | 1.7503 mL | 4.3757 mL | |
| 20 mM | 0.1313 mL | 0.6564 mL | 1.3127 mL | 3.2818 mL | |
| 25 mM | 0.1050 mL | 0.5251 mL | 1.0502 mL | 2.6254 mL | |
| 30 mM | 0.0875 mL | 0.4376 mL | 0.8751 mL | 2.1879 mL | |
| 40 mM | 0.0656 mL | 0.3282 mL | 0.6564 mL | 1.6409 mL | |
| 50 mM | 0.0525 mL | 0.2625 mL | 0.5251 mL | 1.3127 mL | |
| 60 mM | 0.0438 mL | 0.2188 mL | 0.4376 mL | 1.0939 mL | |
| 80 mM | 0.0328 mL | 0.1641 mL | 0.3282 mL | 0.8204 mL | |
| 100 mM | 0.0263 mL | 0.1313 mL | 0.2625 mL | 0.6564 mL |
PDK1-IN-RS2 Related Classifications
HY-114645 Related Classifications
Powered by Bioz