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Cat. No.: HY-136111

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KR-26556

KR-26556 is a sulfonamide type hepatitis B virus (HBV) capsid assembly regulator. KR-26556 exhibits anti-HBV activity with an EC₅₀ of 0.04 μM. KR-26556 has favorable safety characteristics. KR-26556 can be used for research on chronic hepatitis B.

For research use only. We do not sell to patients.

CAS No.: 2411762-66-6
Formula: C₁₈H₁₇F₄N₃O₄S
Molecular Weight:447.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

KR-26556 Chemical Structure

CAS No.: 2411762-66-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	8.78 μM Compound: 11; KR-26556	Inhibition of human ERG expressed in human HEK293 cells by patch clamp assay Inhibition of human ERG expressed in human HEK293 cells by patch clamp assay	[PMID: 32071684]
HepG2 2.2.15	CC₅₀	19.7 μM Compound: 15; KR-26556	Cytotoxicity against human HepG2 2.2.15 cells assessed as reduction in cell viability incubated for 5 days by MTT assay Cytotoxicity against human HepG2 2.2.15 cells assessed as reduction in cell viability incubated for 5 days by MTT assay	[PMID: 33603970]

Chemical Information

CAS No. 2411762-66-6
Molecular Weight 447.40
Formula C₁₈H₁₇F₄N₃O₄S
SMILES

O=C(NC1=CC(F)=C(F)C(F)=C1)C2=CC(S(=O)(N3CCC(O)CC3)=O)=C(F)C=C2N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Na HG, et al. Discovery of a New Sulfonamide Hepatitis B Capsid Assembly Modulator. ACS Med Chem Lett. 2020 Jan 9;11(2):166-171. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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