Silver sulfadiazine  (Synonyms: AgSD)

Silver sulfadiazine (AgSD), a sulfonamide antibiotic, effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis. The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication^[1].

Silver sulfadiazine (AgSD) is a topical antibiotic used to the research of bacterial infection in burns^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

357.14

C₁₀H₉AgN₄O₂S

22199-08-2

Solid

White to off-white

NC(C=C1)=CC=C1S2(=O[Ag+][N]3=CC=C[N-]C3=N2)=O

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

• [1]. Strydom SJ, et al. Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity. Nanomedicine. 2013;9(1):85-93.  [Content Brief]

  [2]. Munhoz DR, et al. Alginate films functionalized with silver sulfadiazine-loaded [Mg-Al] layered double hydroxide as antimicrobial wound dressing. Int J Biol Macromol. 2019;141:504-510.  [Content Brief]