2. Metabolic Enzyme/Protease
  3. PANK
  4. Pantothenate kinase-IN-3

Pantothenate kinase-IN-3 is an orally active PANK3-selective binder and CoA biosynthesis activator with a human PANK3 Ki of 9.1 nM, human PANK3 Ka of 1.8 nM, human PANK1β Ki of 113 nM, human PANK1β Ka of 23.4 nM, and oral effectiveness.Pantothenate kinase-IN-3 binds PANK3 via a water-mediated interaction between its sulfonamide NH and Gly193, elevates cellular, hepatic, and forebrain CoA levels, and shows improved metabolic stability in mouse and human microsomes.Pantothenate kinase-IN-3 has solubility properties favorable at pH 7.Pantothenate kinase-IN-3 can be used for the research of hepatic metabolic CoA deficiencies (acidemias).

For research use only. We do not sell to patients.

Pantothenate kinase-IN-3

Pantothenate kinase-IN-3 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Pantothenate kinase-IN-3 Related Antibodies

Top Publications Citing Use of Products

View All PANK Isoform Specific Products:

View All Isoforms
PanK1 PanK2 PanK3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pantothenate kinase-IN-3 is an orally active PANK3-selective binder and CoA biosynthesis activator with a human PANK3 Ki of 9.1 nM, human PANK3 Ka of 1.8 nM, human PANK1β Ki of 113 nM, human PANK1β Ka of 23.4 nM, and oral effectiveness.Pantothenate kinase-IN-3 binds PANK3 via a water-mediated interaction between its sulfonamide NH and Gly193, elevates cellular, hepatic, and forebrain CoA levels, and shows improved metabolic stability in mouse and human microsomes.Pantothenate kinase-IN-3 has solubility properties favorable at pH 7.Pantothenate kinase-IN-3 can be used for the research of hepatic metabolic CoA deficiencies (acidemias)[1].

IC50 & Target

PanK1β

108.2 nM (Ki)

PanK3

4.2 nM (Ki)

In Vitro

Pantothenate kinase-IN-3 (compound 21) (1-10 μM; 24 h) elevates total cellular CoA levels in human C3A liver cells to 154.32% of control when treated at 1 μM for 24 h[1].
Pantothenate kinase-IN-3 (1 μM; up to 4 h) has improved metabolic stability in vitro, with a half-life of 0.87 h in mouse liver microsomes and a half-life greater than 2 h in human liver microsomes at 1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pantothenate kinase-IN-3 Related Antibodies

ELISA Assay[1]

Cell Line: human C3A liver cells
Concentration: 1-10 μM
Incubation Time: 24 h
Result: Elevated total cellular CoA levels.
In Vivo

Pantothenate kinase-IN-3 (compound 21) (10 mg/kg; p.o.; once daily; 3 days) significantly elevates liver CoA levels to ~215% of control in healthy C57Bl6/J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl6/J mice (6−8 weeks old; fed pantothenic acid-supplemented purified diet for 2 weeks prior to treatment)[1]
Dosage: 10 mg/kg
Administration: p.o.; once daily; 3 days
Result: Elevated liver CoA levels to ~215% of control (p=0.0048).
Elevated forebrain CoA levels to ~110% of control (no statistically significant increase relative to control, p=not significant).
Did not significantly elevate hindbrain CoA levels relative to control.
Molecular Weight

441.91

Formula

C18H21ClFN5O3S
SMILES

CCS(=O)(NC1=CC=C(CC(N2CCN(C3=NN=C(Cl)C=C3)CC2)=O)C=C1F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Pantothenate kinase-IN-3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pantothenate kinase-IN-3PANKPantothenate Kinasemouse liver microsomesPANK3Gly193hepatic metabolic CoA deficienciesforebrainCoA biosynthesishuman liver microsomeshuman PANK1βhuman C3A liver cellsC57Bl6/J miceInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Pantothenate kinase-IN-3
Cat. No.:
HY-181917
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.