CAII/lX-IN-1
CAII/lX-IN-1 (compound 14 (21,301,644)) is an inhibitor belonging to the N-acyl sulfonamides class, which selectively targets Carbonic Anhydrase IX and II. The IC50 values of CAII/lX-IN-1 against hCA-IX and hCA-II are 1.2 μM and 6.7 μM, respectively, with corresponding Ki values of 0.9 and 4.8.
For research use only. We do not sell to patients.
- CAS No.: 2955799-99-0
- Formula: C19H24N8O4S2
- Molecular Weight:492.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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hCA I 1.2 μM (IC50) |
hCA II 6.7 μM (IC50) |
hCA I 0.9 μM (Ki) |
hCA II 4.8 μM (Ki) |
In Vitro
CAII/lX-IN-1 (5 ns, molecular dynamics simulations) bind to hCA-IX and hCA-II via sulfonamide coordination to the active site zinc ion, with binding interactions consistent with experimental inhibitory potency and selectivity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
Chemical Information
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CAS No. 2955799-99-0
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Molecular Weight 492.58
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Formula C19H24N8O4S2
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SMILES
CN(C)C1=NOC(CCNC(S2)=NC=C2S(NC(C3=CC=NC(N4CCCC4)=C3)=O)(=O)=O)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAII/lX-IN-1 Related Classifications
HY-181689 Related Classifications
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