1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Sulfaguanidine

Sulfaguanidine 

Cat. No.: HY-B1267 Purity: ≥98.0%
Handling Instructions

Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery.

For research use only. We do not sell to patients.

Sulfaguanidine Chemical Structure

Sulfaguanidine Chemical Structure

CAS No. : 57-67-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Description

Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery[1][2].

In Vivo

Sulfaguanidine (2.5 mg/kg; i.v.) exhibits CLt (adult 0.29, neonate 0.14 L/h/kg), AUC0-∞ (adult 8.18, neonate 20.46 μg•h/mL), and Vdss (adult 0.65, neonate 0.59 L/kg) in rats[3].
Sulfaguanidine (2.5 mg/kg; p.o.) exhibits absolute bioavailability (adult 12.76%, neonate 57.86%), Cmax (adult 0.41, neonate 3.56 μg/mL), and Tmax (adult 1.67, neonate 1.50 h) in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

214.24

Formula

C₇H₁₀N₄O₂S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (466.77 mM; Need ultrasonic)

H2O : 3.33 mg/mL (15.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6677 mL 23.3383 mL 46.6766 mL
5 mM 0.9335 mL 4.6677 mL 9.3353 mL
10 mM 0.4668 mL 2.3338 mL 4.6677 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.67 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Sulfaguanidine
Cat. No.:
HY-B1267
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