hCAIX-IN-19
hCAIX-IN-19 is a sulfonamides inhibitor against hCA IX with an inhibition constant (KI ) of 6.2 nM and show good selectivity over hCA I (hCA I/ hCA IX = 117).
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- Formule: C29H34N4O4S2
- Masse moléculaire:566.73
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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hCA IX 6.2 nM (Ki) |
In Vitro
hCAIX-IN-19 (1.0-100.0 μM, 48 h ) shows antiproliferative activity in U87MG cells, MDA-MB-231 cells and PANC-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:U87MG cells, MDA-MB-231 cells, PANC-1 cells
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Concentration:1.0 μM, 3.0 μM, 10.0 μM, 30.0 μM, 100.0 μM
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Incubation Time:48 h
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Result:Obviously affected cell proliferation at 100 μM in U87MG cells.
Reduced cell proliferation to 39% at the highest dose tested in MDA-MB-231 cells.
Chemical Information
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Masse moléculaire 566.73
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Formule C29H34N4O4S2
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SMILES
O=C1N[C@@]2([H])[C@@](CS[C@H]2CCCCC(N(CC3=CC=C(C=CC=C4)C4=C3)CCC5=CC=C(S(=O)(N)=O)C=C5)=O)([H])N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAIX-IN-19 Related Classifications
HY-157135 Related Classifications
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