Search Result

Results for "

TNFα release

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) Adenosine Receptor (1) Adrenergic Receptor (3) Akt (2) Amyloid-β (5) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (23) Atg8/LC3 (1) Autophagy (2) Bacterial (6) Bcl-2 Family (2) Beclin1 (1) Beta-lactamase (1) Beta-secretase (2) c-Fms (1) Calcium Channel (3) Caspase (8) CD3 (1) CD73 (1) CDK (1) Cholinesterase (ChE) (6) COX (13) CXCR (1) Drug Metabolite (1) Endogenous Metabolite (3) Environmental Pollutants (2) Epoxide Hydrolase (2) ERK (6) Exosomes (1) FAK (1) Farnesyl Transferase (1) Formyl Peptide Receptor (FPR) (2) Glucocorticoid Receptor (2) GLUT (1) Glutathione Peroxidase (1) Glycosidase (3) HDAC (2) HIF/HIF Prolyl-Hydroxylase (3) IFNAR (7) Influenza Virus (1) Interleukin Related (52) IRAK (3) Isotope-Labeled Compounds (5) JAK (1) JNK (6) Keap1-Nrf2 (2) Lactate Dehydrogenase (5) Leukotriene Receptor (1) Lipoxygenase (1) mAChR (1) Macrophage migration inhibitory factor (MIF) (1) MAP3K (2) MAPKAPK2 (MK2) (1) Mas-related G-protein-coupled Receptor (MRGPR) (1) MDM-2/p53 (1) Melanocortin Receptor (3) mGluR (1) MMP (9) Monoamine Oxidase (2) mTOR (3) nAChR (2) NF-κB (22) NO Synthase (14) NOD-like Receptor (NLR) (4) Nuclear Factor of activated T Cells (NFAT) (1) P2Y Receptor (1) p38 MAPK (19) Parasite (4) PARP (1) PGE synthase (1) Phosphatase (1) Phosphodiesterase (PDE) (10) Phospholipase (1) PKC (2) Potassium Channel (2) Prostaglandin Receptor (2) PROTACs (3) Proteasome (1) Pyroptosis (1) Pyruvate Kinase (2) Ras (1) Reactive Oxygen Species (ROS) (11) Reference Standards (13) RIP kinase (2) Salt-inducible Kinase (SIK) (1) SOD (2) Src (1) STAT (4) STING (1) Tau Protein (1) TNF Receptor (68) Toll-like Receptor (TLR) (8) Transmembrane Glycoprotein (1) TRP Channel (3) γ-secretase (2)
By Research Areas:	Cancer (30) Cardiovascular Disease (10) Endocrinology (2) Infection (17) Inflammation/Immunology (109) Metabolic Disease (10) Neurological Disease (24)
Oligonucleotides:	Cholesterol (2)

131

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: CRAC Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12085

Apremilast 5+ Cited Publications CC-10004	Phosphodiesterase (PDE) Apoptosis TNF Receptor	Inflammation/Immunology
Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM .

HY-123942

Diprovocim 10+ Cited Publications	Toll-like Receptor (TLR) TNF Receptor p38 MAPK NF-κB	Inflammation/Immunology Cancer
Diprovocim is a potent TLR1/TLR2 agonist. Diprovocim elicits full agonist activity in human THP-1 cells (EC₅₀=110 pM). Diprovocim stimulates the release of *TNF-α* from mouse macrophages (EC₅₀=1.3 nM). Diprovocim activates downstream MAPK and NF-κB signaling pathway. Diprovocim displays strong adjuvant activity in mice, particularly abetting cellular immune responses .

HY-N6796

Manumycin A 2 Publications Verification	Antibiotic Exosomes Farnesyl Transferase Ras Apoptosis Phospholipase TNF Receptor Atg8/LC3	Infection Inflammation/Immunology Cancer
Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 (TrxR-1). Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3. Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by *TNF α, and has potential anti-inflammatory activity. Manumycin A can inhibit the Ras/Raf/ERK1/2* signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion .

HY-N0472

Geraniin 3 Publications Verification	TNF Receptor	Metabolic Disease Inflammation/Immunology Cancer
Geraniin is a *TNF-α* releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC₅₀ of 43 μM.

HY-109804

CORM-401 10+ Cited Publications	Reactive Oxygen Species (ROS)	Inflammation/Immunology
CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis .

HY-N0631

Cornuside 5+ Cited Publications	p38 MAPK NF-κB JNK Cholinesterase (ChE) Acyltransferase NO Synthase Interleukin Related TNF Receptor Prostaglandin Receptor ERK COX	Neurological Disease Inflammation/Immunology
Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC₅₀ = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, *TNF-α, IL-6, and IL-1β*, by suppressing NF-κB activation .

HY-N2350

Cynaropicrin	MMP NF-κB TNF Receptor	Cancer
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC₅₀s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

HY-119307

Apratastat 4 Publications Verification TMI-005	MMP TNF Receptor	Cancer
Apratastat (TMI-005) is an orally active, non-selective and reversible TACE/MMPs inhibitor, can inhibit inhibit the release of *TNF-α*. Apratastat has the potential to overcome radiotherapy-resistance in non-small cell lung cancer (NSCLC) . Apratastat is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P991400

GSK1995057	TNF Receptor Apoptosis Interleukin Related NF-κB JNK p38 MAPK	Inflammation/Immunology
GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 selectively binds to TNFR1, blocks the binding of *TNF-α* and LT-α, and does not interfere with TNFR2 signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting IL-1β, IL-6, IL-10, *TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1* and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury .

HY-N4285

Negletein 5,6-Dihydroxy-7-methoxyflavone	TNF Receptor Interleukin Related Reactive Oxygen Species (ROS) Keap1-Nrf2 Amyloid-β	Infection Neurological Disease Inflammation/Immunology Cancer
Negletein (5,6-Dihydroxy-7-methoxyflavone) is a flavone found in Scutellaria. Negletein shows anti-inflammatory activity via inhibiting *TNF-α* and IL-1β with IC₅₀ values of 16.4 and 6.4 μM, respectively. Negletein can activate Nrf2 and inhibit ROS production. Negletein can enhance the neuroprotective effect of nerve growth factor. Negletein can inhibit amyloid beta-peptide release and accumulation. Negletein can inhibit pathogens biofilms formation. Negletein can be used for the researches of cancer, infection, inflammation and neurological disease, such as colon cancer and Alzheimer's disease .

HY-105028

Tenidap CP-66248	COX Lipoxygenase Potassium Channel MMP	Inflammation/Immunology
Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and COX with anti-inflammatory and immunomodulatory properties. Tenidap downregulates the expression of IL-1 receptors in chondrocytes, reduces the release of pro-inflammatory cytokines such as IL-1, IL-6 and *TNF-α, and inhibits MMP* production and cartilage degradation. Tenidap also blocks bone resorption and leukocyte adhesion to vascular endothelium, interferes with ion and pH changes associated with mouse sperm capacitation, and selectively enhances the activity of hKir2.3 channels (EC₅₀=1.3 μM). Tenidap is applicable to research related to rheumatoid arthritis .

HY-N4323

14-Deoxyandrographolide 1 Publications Verification	Calcium Channel Apoptosis Caspase	Neurological Disease Metabolic Disease
14-Deoxyandrographolide is a diterpene with calcium channel blocking activity and acts as a uterine smooth muscle relaxant. 14-Deoxyandrographolide stimulates the release of nitric oxide (NO) in endothelial cells. 14-Deoxyandrographolide gradually desensitizes liver cells to TNF-α mediated apoptosis by inducing the release of TNFRSF1A .

HY-19717

DCVC S-[(1E)-1,2-Dichloroethenyl]-L-cysteine	TNF Receptor	Inflammation/Immunology
DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and *TNF-α* release from tissue cultures .

HY-175479

GLPG4970	Salt-inducible Kinase (SIK) TNF Receptor Interleukin Related	Inflammation/Immunology
GLPG4970 is a potent, selective and orally active salt-inducible kinase 2/3 (SIK2/SIK3) dual inhibitor with IC₅₀ values of 0.3 nM and 0.7 nM. GLPG4970 has weak inhibition of hERG channel with an IC₅₀ of 29 μM. GLPG4970 can decrease TNFα release and increase IL-10 release GLPG4970 can be used for the researches of inflammation and immunology, such as colitis .

HY-147506

NOD2 antagonist 1	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC₅₀ of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs .

HY-B1197

Amcinonide CL-34699	Glucocorticoid Receptor NO Synthase Interleukin Related TNF Receptor	Inflammation/Immunology Endocrinology
Amcinonide is an inhibitor of NO release (IC₅₀ = 3.38 nM). Amcinonide inhibits NNC-induced expression of the proinflammatory genes iNOS, *TNF-α, and IL-1β* in glial cells. Amcinonide reduces the numbers of T6+/Ia+ cells with a concomitant increase in T6+/Ia- cells. Amcinonide induces a selective reduction in expression of Ia antigens. Amcinonide can also be studied in research for eczematous dermatitis .

HY-N7926

Pentadecane	Environmental Pollutants Apoptosis Parasite TNF Receptor Interleukin Related	Infection Inflammation/Immunology
Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC₅₀ values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of *TNF-α* and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis .

HY-112389

p38 MAP Kinase Inhibitor III 2 Publications Verification	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an ₅₀ of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with ₅₀ values of 0.37 μM and 0.044 μM, respectively .

HY-172458

Z-3578 1 Publications Verification	Mas-related G-protein-coupled Receptor (MRGPR) TNF Receptor	Inflammation/Immunology
Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity, exhibiting a K_D value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of β-hexosaminidase, significantly reduces the release of histamine and *TNF-α*, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions .

HY-135674

SR-318 1 Publications Verification	p38 MAPK TNF Receptor	Inflammation/Immunology Cancer
SR-318, a chemical probe, is a potent and highly selective p38 MAPK inhibitor with IC₅₀s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the *TNF-α* release in whole blood with an IC₅₀ of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity .

HY-W015515

L-Citronellol (S)-3,7-Dimethyloct-6-en-1-ol	Environmental Pollutants TNF Receptor Beta-secretase γ-secretase ERK Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces *TNF-α* expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD) .

HY-14562

TBPB	mAChR Amyloid-β	Neurological Disease Inflammation/Immunology
TBPB (tert-butyl peroxybenzoate) is a highly selective, blood-brain-permeable M1 mAChR allosteric agonist (EC₅₀=289 nM) with anti-schizophrenia and anti-inflammatory activities. TBPB can enhance the sensitivity of M1 receptors to acetylcholine, activate downstream signaling pathways, and inhibit the release of pro-inflammatory cytokines (TNF-α, IL-6). TBPB can regulate the processing of amyloid and can be used in the study of neurodegenerative diseases (such as Alzheimer's disease) and inflammation-related diseases (such as sepsis) .

HY-12085S

Apremilast-d5 CC-10004-d₅	Phosphodiesterase (PDE) TNF Receptor Apoptosis	Inflammation/Immunology
Apremilast-d₅ is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM .

HY-174066

SI-W052	mTOR Autophagy Interleukin Related	Neurological Disease Inflammation/Immunology
SI-W052 is an orally active, brain-penetrant and selective small-molecule inhibitor targeting mTOR and TEX264. SI-W052 activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6). SI-W052 is promising for research of Alzheimer’s disease (AD)-associated neuroinflammation .

HY-170495

HDAC6 degrader-5	HDAC Apoptosis Interleukin Related	Inflammation/Immunology
HDAC6 degrader-5 (Compound 6) exhibits inhibitory and degradation activity against HDAC6, with an IC₅₀ of 4.95 nM and a DC₅₀ of 0.96 nM. HDAC6 degrader-5 inhibits the release of TNF-α, IL-1β and IL-6, blocks the hepatocyte apoptosis. HDAC6 degrader-5 exhibits anti-inflammatory activity in mouse APAP (HY-66005)-induced liver injury models .

HY-114221

Org 48762-0 UR13870	p38 MAPK	Inflammation/Immunology
Org 48762-0 (UR13870) is a potent, orally active and selective p38 inhibitor with an EC₅₀ of 0.1 μM for p38α kinase. Org 48762-0 shows a high degree of kinase selectivity for p38α and p38β over other kinases. Org 48762-0 reduces Lipopolysaccharides (HY-D1056) (LPS)-induced TNFα release. Org 48762-0 can be used for the study of rheumatoid arthritis (RA) and Werner syndrome .

HY-113898

Ganoderic acid K	Angiotensin-converting Enzyme (ACE) Toll-like Receptor (TLR) Interleukin Related	Cardiovascular Disease Neurological Disease
Ganoderic acid K is a triterpenoid compound. Ganoderic acid K can be isolated from Ganoderma lucidum. Ganoderic acid K inhibits ACE activity with an IC₅₀ of 2.6×10 ^-5 M. Ganoderic acid K exhibits direct, high-affinity binding to recombinant MD2 protein, with a K_d value of 0.47 μM. It potently inhibits LPS-induced release of *TNF-α* and IL-6. It reduces cerebral infarction volume and ameliorates neurological dysfunction in mice with ischemic stroke in the tMCAO model. Ganoderic acid K can be used in studies related to hypertension and ischemic stroke .

HY-W015515R

L-Citronellol (Standard) (S)-3,7-Dimethyloct-6-en-1-ol (Standard)	Reference Standards ERK Beta-secretase γ-secretase Cholinesterase (ChE) TNF Receptor	Neurological Disease Inflammation/Immunology
L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is an analytical standard for L-Citronellol (HY-W015515). This product is intended for research and analytical applications. L-Citronellol is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces *TNF-α* expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD).

HY-136010

RIP2 Kinase Inhibitor 4	RIP kinase PROTACs	Inflammation/Immunology
RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC₅₀ of 8) and inhibits the release of related TNF-α .

HY-100376

CPI-1189	TNF Receptor Apoptosis	Infection Neurological Disease
CPI-1189 is an orally active *TNF-α* release inhibitor. CPI-1189 inhibits phosphorylation of p38. CPI-1189 can inhibit apoptosis. CPI-1189 can be used in the study of HIV and neurological diseases .

HY-N3421

Koaburaside	Interleukin Related TNF Receptor Influenza Virus	Infection Inflammation/Immunology Cancer
Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC₅₀ of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and *TNF-α* in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .

HY-B1615R

Clenbuterol (Standard) NAB-365 (Standard)	Reference Standards Adrenergic Receptor	Inflammation/Immunology
Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

HY-168482

NF-κB/MAPK-IN-2	NF-κB p38 MAPK	Cancer
NF-κB/MAPK-IN-2 (compound 14) is a potent NF-κB and MAPK Inhibitor. NF-κB/MAPK-IN-2 decreases the protein expression of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. NF-κB/MAPK-IN-2 reduces the LPS-induced release of TNF-α and IL-6. NF-κB/MAPK-IN-2 inhibits nuclear translocation of p65 and c-Fos. NF-κB/MAPK-IN-2 has the potential for the research of sepsis .

HY-177305

Anti-inflammatory agent 105	TNF Receptor	Inflammation/Immunology
Anti-inflammatory agent 105 (Compound 12) is an anti-inflammatory compound. The IC₅₀ of Anti-inflammatory agent 105 for the inhibition of TNF-α synthesis and release in the human macrophage cell line U937 is 0.124 nM .

HY-144368

CO delivery molecule 1	TNF Receptor	Inflammation/Immunology
CO delivery molecule 1 (compound 4) localizes to the endoplasmic reticulum, mitochondria, and lysosomes. Subcellular localization of CO delivery molecule 1 results in CO-induced toxicity effects. Anti-inflammatory effects of CO delivery molecule 1, as measured by TNF-α suppression, occur at the nanomolar level in the absence of CO release, and are enhanced with visible-light-induced CO release .

HY-N4323R

14-Deoxyandrographolide (Standard)	Reference Standards Calcium Channel Apoptosis Caspase	Neurological Disease Metabolic Disease
14-Deoxyandrographolide (Standard) is the analytical standard of 14-Deoxyandrographolide. 14-Deoxyandrographolide is a diterpene with calcium channel blocking activity and acts as a uterine smooth muscle relaxant. 14-Deoxyandrographolide stimulates the release of nitric oxide (NO) in endothelial cells. 14-Deoxyandrographolide gradually desensitizes liver cells to TNF-α mediated apoptosis by inducing the release of TNFRSF1A .

HY-12085R

Apremilast (Standard) CC-10004 (Standard)	Reference Standards Phosphodiesterase (PDE) Apoptosis TNF Receptor	Inflammation/Immunology
Apremilast (Standard) is the analytical standard of Apremilast. This product is intended for research and analytical applications. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM .

HY-177304

Anti-inflammatory agent 104	TNF Receptor	Inflammation/Immunology
Anti-inflammatory agent 104 (Compound 26) is an anti-inflammatory compound. The IC₅₀ of Anti-inflammatory agent 104 for the inhibition of TNF-α synthesis and release in the human macrophage cell line U937 is 0.024 nM. Anti-inflammatory agent 104 can reduce eosinophils in rat lungs by 63% .

HY-108623

Atizoram CP-80,633	Phosphodiesterase (PDE)	Inflammation/Immunology
Atizoram (CP-80,633) is an orally active phosphodiesterase type 4 (PDE4) inhibitor. Atizoram blocks cAMP degradation, thereby increasing intracellular and plasma cAMP levels. Atizoram inhibits *TNFα* release. Atizoram can be used in research related to acute respiratory distress syndrome .

HY-B1615

Clenbuterol NAB-365	Adrenergic Receptor	Inflammation/Immunology
Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC₅₀ of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

HY-175293

SMU-C68	Toll-like Receptor (TLR) NF-κB p38 MAPK	Cancer
SMU-C68 is a highly selective small-molecule TLR1/2 heterodimer agonist (EC₅₀=0.009 μM). SMU-C68 activates NF-κB and MAPK pathways to promote pro-inflammatory cytokine release (e.g., TNF-α, IL-1β). SMU-C68 is promising for research of cancers .

HY-N15708

Dichotomine C (R)-(-)-Dichotomine C	Glycosidase TNF Receptor Interleukin Related	Inflammation/Immunology
Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of β-hexosaminidase in RBL-2H3 cells with an IC₅₀ of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated *TNF-α* and IL-4 in RBL-2H3 cells with IC₅₀s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions .

HY-P991274

BMS-986010	Interleukin Related	Inflammation/Immunology
BMS-986010 is a monoclonal antibody inhibitor targeting the p19 subunit of interleukin-23 (IL-23). BMS-986010 reduces IL-23-induced STAT3 phosphorylation and inhibits Th17 cell differentiation and the release of proinflammatory cytokines (such as IL-17 and TNF-α). BMS-986010 is promising for research of autoimmune diseases such as psoriasis and Crohn's disease .

HY-118984

CRX-526	Toll-like Receptor (TLR)	Inflammation/Immunology
CRX-526 is a TLR4 antagonist that can block the interaction of lipopolysaccharide (LPS, HY-D1056) with the immune system, including preventing the expression of pro-inflammatory genes stimulated by LPS, as well as blocking the release of *TNF-α* induced by LPS. CRX-526 exhibits anti-inflammatory effects in two mouse models of colitis (namely, the dextran sodium sulfate-induced colitis model and the multidrug resistance gene 1a-deficient mouse model) .

HY-162649

TIC10g	Toll-like Receptor (TLR) NF-κB p38 MAPK	Inflammation/Immunology
TIC10g is a dual inhibitor for toll-like receptor 7 and 9 (TLR7 and TLR9), which inhibits TLR7 and TLR9 mediated TNF-α release in mouse macrophages (IC₅₀ is 14.5 μM and 6.5 μM) and human B lymphocytes (IC₅₀ is 7.69 μM and 11.5 μM). TIC10g inhibits the activation of NF-κB and MAPK, and exhibits anti-inflammatory activity against systemic lupus erythematosus and rheumatoid arthritis .

HY-P991634

IBI-325	CD73 TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology Cancer
IBI-325 is a humanized monoclonal antibody inhibitor targeting CD73. IBI-325 completely inhibits CD73 enzymatic activity without hook effect. IBI-325 reverses Adenosine monophosphate (HY-A0181)-mediated immune suppression and significantly inhibits T cell proliferation and cytokines (IL-2, IFN-γ and TNF-α) release. IBI-325 has potent antitumor activities in hPBMC-reconstituted mice model and hCD73 knock-in mice model. IBI-325 can be used for cancer immunotherapy research .

HY-108162A

Ataquimast	COX Leukotriene Receptor TNF Receptor c-Fms	Inflammation/Immunology
Ataquimast is a COX-2 inhibitor that inhibits the release of leukotrienes, TNF-α and GM-CSF. Ataquimast can be used in the study of advanced receptor-positive breast cancer .

HY-12348

LEO 29102	Phosphodiesterase (PDE)	Inflammation/Immunology
LEO 29102 is a potent phosphodiesterase 4 (PDE4) inhibitor with an IC₅₀ value of 5 nM. LEO 29102 inhibits TNFα release. LEO 29102 has the potential for the research of atopic dermatitis .

HY-172195

FS-694	p38 MAPK	Inflammation/Immunology
FS-694, a chemical probe, is the inhibitor for p38α with an IC₅₀ of 0.2 nM. FS-694 inhibits the TNFα release in human whole blood with an IC₅₀ of 35.0 nM .

HY-108162

Ataquimast free base	COX	Inflammation/Immunology
Ataquimast free base is a COX-2 inhibitor that inhibits the release of leukotrienes, TNF-α and GM-CSF. Ataquimast free base can be used in the study of advanced receptor-positive breast cancer .

Cat. No.	Product Name	Type

HY-108910

Chymotrypsin

2 Publications Verification

EC 3.4.21.1; Chymotrypsin A

Biochemical Assay Reagents

Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin downregulates the TLR4/NF-κB signaling pathway, inhibiting the release of inflammatory factors, reducing cell infiltration and tissue damage. It also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54) and can be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions. It can be used in research on diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin can be used in studies of inflammation, edema, and expectoration .

Cat. No.	Product Name	Target	Research Area

HY-P4744

LL-37 amide 2 Publications Verification	Formyl Peptide Receptor (FPR) Bacterial	Infection Cancer
LL-37 amide is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED₉₉=8.5-8.7 μg/mL). LL-37 amide exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .

HY-P4744A

LL-37 amide TFA 2 Publications Verification	Formyl Peptide Receptor (FPR) Bacterial	Infection Cancer
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED₉₉=8.5-8.7 μg/mL). LL-37 amide TFA exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide TFA possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .

HY-P4846

Ac-Pro-Gly-Pro-OH 2 Publications Verification	CXCR Apoptosis IFNAR TNF Receptor Interleukin Related	Infection Inflammation/Immunology
Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and acts as a CXCR2 agonist . Ac-Pro-Gly-Pro-OH exerts bactericidal activity by generating hydrogen peroxide, inhibits pulmonary inflammation, and reduces immune cell apoptosis (apoptosis). Ac-Pro-Gly-Pro-OH promotes the production of IFN-γ and inhibits the production of *TNF-α* and IL-6 in leukocytes. Ac-Pro-Gly-Pro-OH increases the survival rate of mice in sepsis models, enhances the bactericidal activity of neutrophils, acts as a neutrophil chemoattractant, induces neutrophil polarization, and regulates inflammatory and repair processes. Ac-Pro-Gly-Pro-OH induces chronic inflammation and tissue remodeling through sustained action. Ac-Pro-Gly-Pro-OH is released via alkaline hydrolysis of corneal proteins in alkali-injured eyes, thereby driving the early infiltration of neutrophils into the cornea. Ac-Pro-Gly-Pro-OH is applicable to research related to sepsis, chronic obstructive pulmonary disease, cystic fibrosis, bronchiolitis obliterans syndrome, severe asthma, idiopathic pulmonary fibrosis, and corneal ulcer .

HY-P3168

Martentoxin	Potassium Channel NO Synthase	Cardiovascular Disease Inflammation/Immunology
Martentoxin, a 4,046 Da polypeptide toxin, is a large-conductance Ca ²⁺-activated K ⁺ (BK_Ca) channel inhibitor. Martentoxin attenuates NO release, inhibits iNOS activation and upregulates eNOS mRNA expression in HUVECs induced by TNF-α. Martentoxin can be used for vascular diseases research .

HY-P5838

Citrullinated LL-37 5cit	Bacterial	Inflammation/Immunology
Citrullinated LL-37 5cit is a citrullinated LL-37 (HY-P1222) peptide. The antiviral and antibacterial effects of Citrullinated LL-37 5cit are significantly reduced compared to native LL-37. Citrullinated LL-37 5cit is unable to reduce LPS-mediated release of TNF-α due to a lack of LPS-binding capacity .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991400

GSK1995057	TNF Receptor Apoptosis Interleukin Related NF-κB JNK p38 MAPK	Inflammation/Immunology
GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 selectively binds to TNFR1, blocks the binding of *TNF-α* and LT-α, and does not interfere with TNFR2 signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting IL-1β, IL-6, IL-10, *TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1* and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury .

HY-P99390

Tepoditamab MCLA 117	CD3 Interleukin Related IFNAR TNF Receptor	Inflammation/Immunology Cancer
Tepoditamab (MCLA-117) is a full-length human IgG1 bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells. Tepoditamab induces upto 30-fold T-cell expansion. Tepoditamab results in moderate to strong cytokine (IFNγ, IL-6, IL-8, IL-10, and TNFα) and IFNγ release in human whole blood and PBMC, respectively. Tepoditamab can be used in acute myeloid leukaemia (AML) research .

HY-P991274

BMS-986010	Interleukin Related	Inflammation/Immunology
BMS-986010 is a monoclonal antibody inhibitor targeting the p19 subunit of interleukin-23 (IL-23). BMS-986010 reduces IL-23-induced STAT3 phosphorylation and inhibits Th17 cell differentiation and the release of proinflammatory cytokines (such as IL-17 and TNF-α). BMS-986010 is promising for research of autoimmune diseases such as psoriasis and Crohn's disease .

HY-P991634

IBI-325	CD73 TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology Cancer
IBI-325 is a humanized monoclonal antibody inhibitor targeting CD73. IBI-325 completely inhibits CD73 enzymatic activity without hook effect. IBI-325 reverses Adenosine monophosphate (HY-A0181)-mediated immune suppression and significantly inhibits T cell proliferation and cytokines (IL-2, IFN-γ and TNF-α) release. IBI-325 has potent antitumor activities in hPBMC-reconstituted mice model and hCD73 knock-in mice model. IBI-325 can be used for cancer immunotherapy research .

HY-P991426

MB-314	Transmembrane Glycoprotein IFNAR TNF Receptor	Cancer
MB-314 is a human IgG1 monoclonal antibody (mAb) targeting Lewis Y. MB-314 induces enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. MB-314 increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 can be used in cancer research .

HY-P991789

Anti-Mouse NKp46 Antibody (29A1.4)	Interleukin Related	Inflammation/Immunology
Anti-Mouse NKp46 Antibody (29A1.4) reacts with mouse NKp46. Anti-Mouse NKp46 Antibody (29A1.4) stimulates the NK cells to produce IFN-γ and TNF-α and to release their cytoplasmic granule contents. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0171A

Beta-Sitosterol (purity>98%) 15+ Cited Publications β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)	Cardiovascular Disease Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD
Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, *TNF-α, IL-1β, and NF-κB p65* and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .

HY-N0171

Beta-Sitosterol (purity>80%) 20+ Cited Publications	Cardiovascular Disease other families Classification of Application Fields Leguminosae Plants Endogenous metabolite Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Steroids Source Classification	Apoptosis Endogenous Metabolite
Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, *TNF-α, IL-1β, and NF-κB p65* and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .

HY-N6796

Manumycin A 2 Publications Verification	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Antibiotic Exosomes Farnesyl Transferase Ras Apoptosis Phospholipase TNF Receptor Atg8/LC3
Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 (TrxR-1). Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3. Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by *TNF α, and has potential anti-inflammatory activity. Manumycin A can inhibit the Ras/Raf/ERK1/2* signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion .

HY-N0637

Eriodictyol 10+ Cited Publications Huazhongilexone	Structural Classification Classification of Application Fields Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids other families Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Melanocortin Receptor TRP Channel
Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC₅₀=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and *TNF-α* in the retina and maintains the integrity of the blood-retinal barrier. Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases .

HY-N0472

Geraniin 3 Publications Verification	Phyllanthus urinaria Linn. Classification of Application Fields Other Phenylpropanoids Phenols Polyphenols Metabolic Disease Euphorbiaceae Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	TNF Receptor
Geraniin is a *TNF-α* releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC₅₀ of 43 μM.

HY-N0631

Cornuside 5+ Cited Publications	Structural Classification Iridoids Cornaceae Classification of Application Fields Cornus officinalis Sieb. et Zucc. Terpenoids Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	p38 MAPK NF-κB JNK Cholinesterase (ChE) Acyltransferase NO Synthase Interleukin Related TNF Receptor Prostaglandin Receptor ERK COX
Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC₅₀ = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, *TNF-α, IL-6, and IL-1β*, by suppressing NF-κB activation .

HY-N0637A

(±)-Eriodictyol (±)-Huazhongilexone; Dihydroluteolin	Structural Classification Flavonoids Lawsonia inermis L. Lythraceae Flavones Plants Source Classification	Melanocortin Receptor TRP Channel
(±)-Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC₅₀=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. (±)-Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. (±)-Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and *TNF-α* in the retina and maintains the integrity of the blood-retinal barrier. (±)-Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. (±)-Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases .

HY-N2736

3′,4′,7-Trihydroxyflavone 1 Publications Verification	Flavonoids Classification of Application Fields Flavones Leguminosae Other Diseases Phenols Polyphenols Plants Vicia faba L. Disease Research Fields Source Classification	Beta-lactamase COX Interleukin Related Bacterial JNK ERK p38 MAPK STAT Apoptosis NO Synthase Nuclear Factor of activated T Cells (NFAT) Lactate Dehydrogenase Reactive Oxygen Species (ROS) SOD Akt Caspase Bcl-2 Family
3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC₅₀ = 1.89 μM) and COX-1 (IC₅₀ = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H₂O₂-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice .

HY-N0171R

Beta-Sitosterol (Standard) 5+ Cited Publications β-Sitosterol (Standard); 22,23-Dihydrostigmasterol (Standard))	Cardiovascular Disease other families Classification of Application Fields Leguminosae Plants Endogenous metabolite Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Steroids Source Classification	Reference Standards Apoptosis Endogenous Metabolite
Beta-Sitosterol (Standard) is the analytical standard of Beta-Sitosterol. This product is intended for research and analytical applications. Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, *TNF-α, IL-1β, and NF-κB p65* and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.

HY-N2350

Cynaropicrin	Saussurea costus (Falc.) Lipsch. Classification of Application Fields Phenols Plants Compositae Disease Research Fields Source Classification Cancer	MMP NF-κB TNF Receptor
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC₅₀s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

HY-N4285

Negletein 5,6-Dihydroxy-7-methoxyflavone	Flavonoids Flavones Labiatae Phenols Polyphenols Plants Medicago truncatula Gaertn. Source Classification	TNF Receptor Interleukin Related Reactive Oxygen Species (ROS) Keap1-Nrf2 Amyloid-β
Negletein (5,6-Dihydroxy-7-methoxyflavone) is a flavone found in Scutellaria. Negletein shows anti-inflammatory activity via inhibiting *TNF-α* and IL-1β with IC₅₀ values of 16.4 and 6.4 μM, respectively. Negletein can activate Nrf2 and inhibit ROS production. Negletein can enhance the neuroprotective effect of nerve growth factor. Negletein can inhibit amyloid beta-peptide release and accumulation. Negletein can inhibit pathogens biofilms formation. Negletein can be used for the researches of cancer, infection, inflammation and neurological disease, such as colon cancer and Alzheimer's disease .

HY-N2374

Eupatorin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Source Classification Cancer	Apoptosis NF-κB MMP Adrenergic Receptor
Eupatorin is an orally active flavonoid with antiproliferative and vasodilatory properties. Eupatorin downregulates the expression levels of NF-κB, MMP9, IL-1β and *TNF-α. Eupatorin induces apoptosis, G2/M phase cell cycle* arrest, and reactive oxygen species (ROS) production. Eupatorin modulates the activities of muscarinic receptors and β-adrenergic receptors; inhibits sarcoplasmic reticulum calcium release and calcium channels; and activates the NO/sGC/cGMP pathway, indomethacin-sensitive pathway, and potassium channel pathway. Eupatorin exerts cytotoxic effects on cancer cell lines, and is metabolized by CYP1A1 and CYP1 family enzymes to form metabolites with antiproliferative activity. Eupatorin can be used in research related to breast cancer, hypertension, and leukemia .

HY-N4323

14-Deoxyandrographolide 1 Publications Verification	Structural Classification Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Source Classification	Calcium Channel Apoptosis Caspase
14-Deoxyandrographolide is a diterpene with calcium channel blocking activity and acts as a uterine smooth muscle relaxant. 14-Deoxyandrographolide stimulates the release of nitric oxide (NO) in endothelial cells. 14-Deoxyandrographolide gradually desensitizes liver cells to TNF-α mediated apoptosis by inducing the release of TNFRSF1A .

HY-N7926

Pentadecane	Structural Classification Natural Products Kaempferia galanga L. Plants Source Classification Zingiberaceae	Environmental Pollutants Apoptosis Parasite TNF Receptor Interleukin Related
Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC₅₀ values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of *TNF-α* and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis .

HY-W015515

L-Citronellol (S)-3,7-Dimethyloct-6-en-1-ol	Zanthoxylum bungeanum Maxim. Structural Classification Other Monoterpenes Terpenoids Rutaceae Plants Source Classification	Environmental Pollutants TNF Receptor Beta-secretase γ-secretase ERK Cholinesterase (ChE)
L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces *TNF-α* expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD) .

HY-N5073

Vitexin-4''-O-glucoside 4''-O-Glucosylvitexin	Cardiovascular Disease Structural Classification Flavonoids Classification of Application Fields Flavones Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Disease Research Fields Source Classification	JNK p38 MAPK Interleukin Related TNF Receptor Caspase Lactate Dehydrogenase Apoptosis
Vitexin-4''-O-glucoside (4''-O-Glucosylvitexin) is an orally active natural flavonoid component with multiple pharmacological effects including antioxidation, anti-inflammation, cytoprotection and anti-apoptosis. Vitexin-4''-O-glucoside regulates the MAPK signaling pathway by downregulating the phosphorylation levels of JNK and p38, thereby blocking endoplasmic reticulum stress responses. Vitexin-4''-O-glucoside alleviates oxidative stress by reducing MDA content and upregulating the activities of SOD and CAT, attenuates inflammation by downregulating the expressions of inflammatory factors *TNF-α, IL-1β* and IL-6, and also reduces LDH release and inhibits caspase-3 activation. Vitexin-4''-O-glucoside effectively improves drug-induced acute liver injury and exerts significant protective effects against myocardial hypoxia/reoxygenation injury. Vitexin-4''-O-glucoside can be used in studies on acute liver injury, cardiovascular diseases and myocardial hypoxia-reoxygenation injury .

HY-121811

Pongamol Lanceolatin C	Structural Classification Pongamia pinnata (L.) Pierre Leguminosae Ketones, Aldehydes, Acids Derris trifoliata Lour. Plants Source Classification	Glycosidase Phosphatase Interleukin Related TNF Receptor COX Beclin1 GLUT FAK Akt mTOR p38 MAPK Keap1-Nrf2 Apoptosis Amyloid-β Tau Protein Autophagy
Pongamol (Lanceolatin C) is an orally active flavonoid with an IC₅₀ of 75 μM and a K_i of 58 μM against PTPase-1B, and an IC₅₀ of 103.5 μM against intestinal α-Glycosidase. Pongamol reduces the release of IL‑1β, *TNF‑α, COX‑2* and iNOS in cells, reverses the nuclear translocation of NF‑κB, and upregulates the levels of Beclin 1 and LC3 Ⅱ/LC3 Ⅰ. Pongamol promotes glucose uptake by increasing the level of GLUT4 on the surface of skeletal muscle cells. Pongamol inhibits epithelial-mesenchymal transition by suppressing the FAK/Akt-mTOR signaling pathway. Pongamol inhibits neuronal cytotoxicity, suppresses cell apoptosis and extends the lifespan of Caenorhabditis elegans by activating the MAPKs/Nrf2 signaling pathway. Pongamol exerts hypoglycemic effects in diabetic mouse models. Pongamol exhibits antibacterial activity. Pongamol alleviates oxidative stress, neuroinflammation, Aβ deposition and excessive phosphorylation of Tau Protein, and restores autophagy function in Alzheimer's disease mouse models by inhibiting the Akt/mTOR signaling pathway. Pongamol is applicable to research related to Alzheimer's disease, type 2 diabetes, non-small cell lung cancer and postprandial hyperglycemia .

HY-W015515R

L-Citronellol (Standard) (S)-3,7-Dimethyloct-6-en-1-ol (Standard)	Zanthoxylum bungeanum Maxim. Structural Classification Other Monoterpenes Terpenoids Rutaceae Plants Source Classification	Reference Standards ERK Beta-secretase γ-secretase Cholinesterase (ChE) TNF Receptor
L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is an analytical standard for L-Citronellol (HY-W015515). This product is intended for research and analytical applications. L-Citronellol is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces *TNF-α* expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD).

HY-N3421

Koaburaside	Eucommia ulmoides Oliver Eucommiaceae Plants Saccharides Monosaccharides Source Classification	Interleukin Related TNF Receptor Influenza Virus
Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC₅₀ of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and *TNF-α* in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .

HY-N4323R

14-Deoxyandrographolide (Standard)	Structural Classification Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Source Classification	Reference Standards Calcium Channel Apoptosis Caspase
14-Deoxyandrographolide (Standard) is the analytical standard of 14-Deoxyandrographolide. 14-Deoxyandrographolide is a diterpene with calcium channel blocking activity and acts as a uterine smooth muscle relaxant. 14-Deoxyandrographolide stimulates the release of nitric oxide (NO) in endothelial cells. 14-Deoxyandrographolide gradually desensitizes liver cells to TNF-α mediated apoptosis by inducing the release of TNFRSF1A .

HY-N15708

Dichotomine C (R)-(-)-Dichotomine C	Alkaloids Stellaria dichotoma L. Plants Caryophyllaceae Indole Alkaloids Source Classification	Glycosidase TNF Receptor Interleukin Related
Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of β-hexosaminidase in RBL-2H3 cells with an IC₅₀ of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated *TNF-α* and IL-4 in RBL-2H3 cells with IC₅₀s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions .

HY-N0472R

Geraniin (Standard)	Phyllanthus urinaria Linn. Structural Classification Other Phenylpropanoids Phenols Polyphenols Euphorbiaceae Phenylpropanoids Plants Source Classification	Reference Standards TNF Receptor
Geraniin (Standard) is the analytical standard of Geraniin. This product is intended for research and analytical applications. Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC₅₀ of 43 μM.

HY-N12116

Maceneolignan A	Monophenols Phenols Myristicaceae Plants Myristica fragrans Houtt. Source Classification	TNF Receptor
Maceneolignan A is a natural product that can be isolated from mace, the aril of Myristica fragrans (Myristicaceae). Maceneolignan A inhibits the release of β-hexosaminidase in RBL-2H3 cells, with an IC₅₀ of 48.4 μM. Maceneolignan A inhibits the release of *TNF-α* in antigen stimulated RBL-2H3 cells, with an IC₅₀ of 63.7 μM .

HY-N2350R

Cynaropicrin (Standard)	Saussurea costus (Falc.) Lipsch. Structural Classification Phenols Plants Compositae Source Classification	Reference Standards MMP NF-κB TNF Receptor
Cynaropicrin (Standard) is the analytical standard of Cynaropicrin. This product is intended for research and analytical applications. Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC₅₀s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

HY-W015546R

β-N-methylamino-L-alanine hydrochloride (Standard) BMAA hydrochloride (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial Reference Standards mGluR PKC
Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

HY-N7926R

Pentadecane (Standard)	Structural Classification Natural Products Kaempferia galanga L. Plants Source Classification Zingiberaceae	Parasite Reference Standards TNF Receptor Interleukin Related Apoptosis
Pentadecane (Standard) is the analytical standard of Pentadecane (HY-N7926). This product is intended for research and analytical applications. Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC₅₀ values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of *TNF-α* and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis .

HY-160121

Patrinoside aglucone Patrinoside aglycone	Structural Classification Caprifoliaceae Iridoids Patrinia scabiosifolia Fisch. ex Trevir. Terpenoids Plants Source Classification	Apoptosis NO Synthase TNF Receptor Interleukin Related PGE synthase COX
Patrinoside aglucone (Compound 8) is an iridoid glucoside that can be isolated from the Valeriana tuberosa. Patrinoside aglucone has potent anticancer activity with G2/M phase tumor cell cycle arrest and apoptosis induction. Patrinoside aglucone also significantly inhibits the proliferation of cancer stem cells (such as MDA-MB-231 and U-251MG cells). Patrinoside aglucone has great anti-inflammatory activity by inhibiting NO release (IC₅₀: 43.44 μM) and significantly reduces the level of *TNF-α, IL-1β, IL-6, PGE2* and COX-2 .

HY-N0631R

Cornuside (Standard)	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Phenols Polyphenols Plants Source Classification	Reference Standards Prostaglandin Receptor ERK p38 MAPK Acyltransferase TNF Receptor COX Cholinesterase (ChE) Interleukin Related JNK NO Synthase NF-κB
Cornuside (Standard) is the analytical standard of Cornuside (HY-N0631). This product is intended for research and analytical applications. Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC₅₀ = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, *TNF-α, IL-6, and IL-1β*, by suppressing NF-κB activation.

HY-N0637AR

(±)-Eriodictyol (Standard) (±)-Huazhongilexone (Standard); Dihydroluteolin (Standard)	Structural Classification Flavonoids Lawsonia inermis L. Lythraceae Flavones Plants Source Classification	Reference Standards Melanocortin Receptor TRP Channel
3-Chlorobenzoic acid (Standard) is the analytical standard of 3-Chlorobenzoic acid. This product is intended for research and analytical applications. (±)-Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC₅₀=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. (±)-Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. (±)-Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and *TNF-α* in the retina and maintains the integrity of the blood-retinal barrier. (±)-Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. (±)-Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases .

HY-149151

Variegatic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite PKC Glycosidase TNF Receptor Reactive Oxygen Species (ROS)
Variegatic acid is a secondary metabolite derived from basidiomycete fungi. Variegatic acid is a PKCβ1 inhibitor with an IC₅₀ of 36.2 μM. Variegatic acid inhibits antigen- or calcium ionophore-induced β-hexosaminidase release (IC₅₀ values of 10.4 μM and 22.2 μM, respectively) and *TNF-α* secretion (IC₅₀ values of 16.8 μM and 20.1 μM, respectively). Variegatic acid suppresses the enzymatic activity of calcium-activated PKCβ1 and reduces Fe(III) to Fe(II) in a pH-dependent manner, enabling the generation of hydroxyl radicals (·OH) through reaction with H₂O₂, which facilitates the degradation of lignocellulose. Variegatic acid is useful for studying biological degradation and allergic responses.

Cat. No.	Product Name	Chemical Structure

HY-12085S

Apremilast-d5
Apremilast-d₅ is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM .

HY-12085S1

Apremilast-d8
Apremilast-d₈ (CC-10004-d₈) is deuterium labeled Apremilast. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM .

HY-12085S3

Apremilast-d3
Apremilast-d₃ (CC-10004-d₃) is deuterium labeled Apremilast. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM .

HY-19717S

DCVC-13C3,15N
DCVC- ¹³C₃, ¹⁵N is ¹⁵N and ¹³C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and *TNF-α* release from tissue cultures .

HY-N7926S

Pentadecane-d32

Pentadecane-d₃₂ is the deuterium labeled Pentadecane (HY-N7926). Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC₅₀ values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of TNF-α and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis .

HY-W753956

Iminostilbene-d10

Iminostilbene-d₁₀ is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases .

Cat. No.	Product Name		Classification

HY-N0171A

Beta-Sitosterol (purity>98%) 15+ Cited Publications β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)		Cholesterol
Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, *TNF-α, IL-1β, and NF-κB p65* and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .

HY-N0171

Beta-Sitosterol (purity>80%) 20+ Cited Publications		Cholesterol
Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, *TNF-α, IL-1β, and NF-κB p65* and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

TNFα release

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products