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aminoglycoside phosphotransferase APH(2'')-IVa

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Aminotransferases (Transaminases) (1) Amyloid-β (1) Antibiotic (94) Apoptosis (1) ATP Synthase (1) Bacterial (102) Biochemical Assay Reagents (10) Calcium Channel (2) Caspase (1) CDK (3) CFTR (1) COX (1) Drug Intermediate (3) Drug Isomer (1) Drug Metabolite (1) Endogenous Metabolite (9) Endothelin Receptor (1) Environmental Pollutants (4) Ephrin Receptor (1) Exosomes (1) Fluorescent Dye (2) Fungal (5) GCGR (1) GnRH Receptor (1) Guanylate Cyclase (1) iGluR (1) Influenza Virus (3) Insulin Receptor (1) Interleukin Related (3) Isotope-Labeled Compounds (3) Keap1-Nrf2 (1) Liposome (1) Melanocortin Receptor (1) MHC (1) NF-κB (1) NO Synthase (9) Parasite (9) PARP (1) PDI (2) Phosphodiesterase (PDE) (2) Phospholipase (4) Prostaglandin Receptor (1) PSMA (2) Pyruvate Kinase (1) Radionuclide-Drug Conjugates (RDCs) (4) Reference Standards (26) Renin (1) RNA MTase (1) SARS-CoV (1) Somatostatin Receptor (5) Thymidylate Synthase (1) TNF Receptor (1) Transglutaminase (2) TRP Channel (1) Tyrosinase (1) Virus Protease (1) Wnt (1) Xanthine Oxidase (1) β-catenin (1)
By Research Areas:	Cancer (34) Cardiovascular Disease (6) Endocrinology (3) Infection (111) Inflammation/Immunology (21) Metabolic Disease (18) Neurological Disease (14)
Oligonucleotides:	Nucleoside Analogs (1) Liposome (1) Uridine (1)

180

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Isotope-Labeled Compounds

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0490

Hygromycin B 35+ Cited Publications Hygrovetine	Bacterial Fungal Antibiotic Parasite	Infection
Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.

HY-B1743

Puromycin Maximum Cited Publications 387 Publications Verification CL13900	Bacterial Antibiotic Parasite	Infection
Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

HY-B1329

Apramycin sulfate 4 Publications Verification Nebramycin II sulfate	Bacterial Antibiotic	Infection
Apramycin (EBL 1003) sulfate is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin sulfate is a potential anti-drug-resistance antibiotic ^[2] .

HY-108718

G-418 60+ Cited Publications Geneticin; Antibiotic G-418	Bacterial Parasite Antibiotic	Infection
G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis .

HY-B0472

Streptomycin sulfate 45+ Cited Publications	Environmental Pollutants Antibiotic Bacterial	Infection
Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis.

HY-B1222

Sisomicin sulfate 5 Publications Verification	Bacterial Antibiotic	Infection
Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria.

HY-B1174

Bekanamycin Kanamycin B	Antibiotic Bacterial	Infection
Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain ^[2].

HY-125685

Germacrene D 1 Publications Verification	Bacterial Fungal	Cancer
Germacrene D is isolated from Solidago canadensis. Germacrene D has antibacterial and antifungal activities and can be used as an adjuvant agent in the application of aminoglycosides and azoles .

HY-B0509B

Amikacin disulfate 25+ Cited Publications BAY 41-6551 disulfate	Bacterial Antibiotic	Infection Cancer
Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria ^[2].

HY-107813

Amikacin sulfate 25+ Cited Publications BAY 41-6551 sulfate	Bacterial Antibiotic	Infection Cancer
Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria ^[2].

HY-A0086

Netilmicin sulfate SCH-20569 sulfate	Bacterial Antibiotic	Infection
Netilmicin (Sch 20569) sulfate is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin sulfate exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL .

HY-N0818

Chikusetsusaponin Iva 2 Publications Verification Calenduloside F	Keap1-Nrf2	Infection Metabolic Disease Endocrinology Cancer
Chikusetsusaponin IVa is an orally active protein kinase activator. Chikusetsusaponin IVa binds to YAP with a K_D value of 0.388 mM. Chikusetsusaponin IVa reduces inflammatory mediators (IL-6, IL-10, *COX-2) expression, NO production, promotes ROS* generation, induces Apoptosis, inhibits MAPK, TAZ, and regulates *Nrf2, JAK/STAT. Chikusetsusaponin Iva* has anti-H9N2 AIV and anti-endometrial cancer activities. Chikusetsusaponin Iva shows anti-inflammatory, hepatoprotective and osteoprotective effects ^[2] .

HY-N7449

Neamine	Antibiotic Bacterial	Infection Cardiovascular Disease Neurological Disease Cancer
Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities ^[2].

HY-P1080

ω-Agatoxin IVA 1 Publications Verification	Calcium Channel	Cardiovascular Disease Neurological Disease
ω-Agatoxin IVA is a potent, selective P/Q type Ca ²⁺ (Cav2.1) channel blocker with IC₅₀ values of 2 nM and 90 nM. ω-Agatoxin IVA inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA inhibits Capsaicin (HY-10448)-induced CGRP release and vasodilation. ω-Agatoxin IVA can be used for the research of neurological and cardiovascular disease ^[2] .

HY-B1915

Micronomicin 1 Publications Verification Gentamicin C2b; Antibiotic XK-62-2; Sagamicin	Antibiotic Bacterial	Infection
Micronomicin (Gentamicin C2b) is an aminoglycoside antibiotic, with antibacterial and bactericidal activities .

HY-B0509

Amikacin hydrate 25+ Cited Publications BAY 41-6551 hydrate	Bacterial Antibiotic	Infection Cancer
Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin hydrate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin hydrate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin hydrate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria ^[2].

HY-B0343A

Sarafloxacin hydrochloride 2 Publications Verification A-56620 hydrochloride	Bacterial	Infection Inflammation/Immunology
Sarafloxacin hydrochloride (A-56620 hydrochloride) is a fluoroquinolone Antibacterial agent. Sarafloxacin inhibits the growth of Staphylococcus aureus, Enterobacteriaceae, and both aminoglycoside-sensitive and aminoglycoside-resistant strains of Pseudomonas aeruginosa ^[2].

HY-W006429

L-Uridine	Endogenous Metabolite	Others
L-Uridine is an enantiomer of the normal RNA constituent D-uridine. L-Uridine can be isolated from the Polyporaceae fungus Poria cocos (Schw.). L-uridine acts as a phosphate acceptor for nucleoside phosphotransferases ^[2].

HY-P2952

Recombinant myokinase, Rabbit muscle Myokinase; Adk	Endogenous Metabolite	Others
Recombinant myokinase, Rabbit muscle (Myokinase), is a phosphotransferase enzyme, is often used in biochemical studies. Recombinant myokinase, Rabbit muscle catalyzes the interconversion of adenosine phosphates. Recombinant myokinase, Rabbit muscle monitors phosphate nucleotide levels inside the cell, it plays an important role in cellular energy homeostasis .

HY-P1080A

*ω-Agatoxin IVA* TFA** 1 Publications Verification	Calcium Channel	Neurological Disease
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca ²⁺ (Cav2.1) channel blocker with IC₅₀ values of 2 nM and 90 nM. ω-Agatoxin IVA TFA inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA inhibits Capsaicin (HY-10448)-induced CGRP release and vasodilation. ω-Agatoxin IVA TFA can be used for the research of neurological and cardiovascular disease ^[2] .

HY-N6942

Mogroside IV-A	Others	Metabolic Disease Cancer
Mogroside IV-A, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities .

HY-N1465

Aristolochic acid D Aristolochic acid-IVa	Phosphodiesterase (PDE) CDK Interleukin Related	Inflammation/Immunology Cancer
Aristolochic acid D (Aristolochic acid-IVa) is an orally active *PDE2* (IC₅₀: 4.673 μM) and *CDK2* (IC₅₀: 25 μM) inhibitor that can be isolated from Aristolochia indica L. Aristolochic acid D exhibits anti-inflammatory activity and is non-carcinogenic and non-nephrotoxic. Aristolochic acid D can be used in the research of inflammation and tumor-related diseases ^[2] .

HY-P2806A

Pyruvate Kinase (PK),Rabbit Muscle ATP:Pyruvate 2-0-phosphotransferase,PK	Pyruvate Kinase	Metabolic Disease Cancer
Pyruvate Kinase (PK),Rabbit Muscle (ATP:Pyruvate 2-0-phosphotransferase,PK) is a biological material or organic compound that can be used in life science research ^[2].

HY-115349

Neamine tetrahydrochloride	Antibiotic Bacterial	Infection Neurological Disease Cancer
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities ^[2].

HY-N125722

Venturicidin A Aabomycin A1	ATP Synthase Antibiotic	Infection
Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

HY-B1222A

Sisomicin 5 Publications Verification Antibiotic 6640; Rickamicin	Bacterial Antibiotic	Infection
Sisomicin is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is highly active against Gram-positive bacteria ^[2].

HY-16955A

Plazomicin sulfate 1 Publications Verification ACHN 490 sulfate	Antibiotic Bacterial	Infection
Plazomicin (ACHN 490) sulfate is a semi-synthetic aminoglycoside Antibiotic. Plazomicin sulfate acts as a substrate for Aminoglycoside acetyltransferase and **Aminoglycoside phosphotransferase*. Plazomicin sulfaten is not modified by various common aminoglycoside-modifying enzymes. Plazomicin sulfate selectively inhibits MATE2-K*. Plazomicin sulfate exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales ^[2].

HY-B1743S

Puromycin-d3 3 Publications Verification CL13900-d₃	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Puromycin-d₃ is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

HY-B0755

Etimicin sulfate	Antibiotic	Infection
Etimicin (sulfate), a fourth-generation aminoglycoside antibiotic, is now widely clinically used due to its high efficacy and low toxicity.

HY-B2094

Arbekacin	Antibiotic Bacterial	Infection
Arbekacin, an aminoglycoside antibiotic, exhibits broad antimicrobial activities against not only Gram-positive bacteria but also Gram-negative bacteria .

HY-147062

N-Acetyl-D-galactosamine-6-phosphate	Biochemical Assay Reagents	Metabolic Disease
N-acetyl-D-galactosamine 6-phosphate is a galactosamine phosphate that involved in galactose metabolism and phosphotransferase system (PTS). N-Acetyl-D-galactosamine-6-phosphate can be hydrolyze by NagA ^[2] .

HY-129677

ORC-13661 hydrochloride	TRP Channel	Others
ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker .

HY-B0470R

Neomycin sulfate (Standard)	Reference Standards Bacterial Antibiotic Phospholipase	Infection Cancer
Neomycin (sulfate) (Standard) is the analytical standard of Neomycin (sulfate). This product is intended for research and analytical applications. Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis ^[2].

HY-114784

Ingavirin Ingamine	Influenza Virus	Infection
Ingavirin (Ingamine) exhibits broad spectrum antiviral activities against human respiratory viruses, such as influenza virus A (IVA), human parainfluenza virus (hPIV) and human adenovirus (AdV). Ingavirin exhibits no toxixcity to mice at the dose of 3000 mg/kg .

HY-N14514

Gentamicin X2	Antibiotic	Infection
Gentamicin X2 is a minor aminoglycoside antibiotic component in the gentamicin complex .

HY-W016456

5-Bromopentanoic acid	Drug Intermediate	Others
5-Bromopentanoic acid can be used for the synthesis of inhibitors for aminoglycoside resistant bacteria .

HY-B1743R

Puromycin (Standard) CL13900 (Standard)	Reference Standards Bacterial Antibiotic Parasite	Infection
Puromycin (Standard) is the analytical standard of Puromycin. This product is intended for research and analytical applications. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

HY-W145483

*Heparin IV-A* sodium** N-Acetyl-de-O-sulfated heparin (Heparin IV-A) sodium	Biochemical Assay Reagents	Others
Heparin IV-A sodium is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-B1329R

Apramycin sulfate (Standard) Nebramycin II sulfate (Standard)	Reference Standards Bacterial Antibiotic	Infection
Apramycin (sulfate) (Standard) is the analytical standard of Apramycin (sulfate). This product is intended for research and analytical applications. Apramycin (EBL 1003) is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin is a potential anti-drug-resistance antibiotic ^[2] .

HY-127054

Netilmicin Sch 20569	Antibiotic Bacterial	Infection
Netilmicin (Sch 20569) is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL .

HY-16955

Plazomicin ACHN 490	Antibiotic Bacterial	Infection Inflammation/Immunology
Plazomicin (ACHN 490) is a semi-synthetic aminoglycoside Antibiotic. Plazomicin acts as a substrate for Aminoglycoside acetyltransferase and **Aminoglycoside phosphotransferase*. Plazomicin is not modified by various common aminoglycoside-modifying enzymes. Plazomicin selectively inhibits MATE2-K*. Plazomicin exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales ^[2].

HY-100782

DL-AP7 2-APH; 2-Amino-7-phosphonoheptanoic acid	iGluR	Neurological Disease
DL-AP7 is a competitive NMDA antagonist and an anticonvulsant. DL-AP7 blocks the NMDA-induced convulsions and impairs learning performance in a passive avoidance task in mice .

HY-E70034

Galactokinase (BiGalK)	Endogenous Metabolite	Metabolic Disease
Galactokinase (BiGalK) is a phosphotransferase. Galactokinase catalyzes ATP-dependent phosphorylation of α-d-galactose to galactose 1-phosphate .

HY-B0343

Sarafloxacin A-56620	Bacterial	Infection Inflammation/Immunology
Sarafloxacin (A-56620) is a fluoroquinolone Antibacterial agent. Sarafloxacin inhibits the growth of Staphylococcus aureus, Enterobacteriaceae, and both aminoglycoside-sensitive and aminoglycoside-resistant strains of Pseudomonas aeruginosa ^[2].

HY-17558

Apramycin 4 Publications Verification Nebramycin II	Bacterial Antibiotic	Infection
Apramycin (Nebramycin II) is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin is a potential anti-drug-resistance antibiotic ^[2] .

HY-P10230

Sublancin	Bacterial	Infection
Sublancin is an antimicrobial peptide, which inhibits DNA replication, transcription and translation, without affecting membrane integrity. Sublancin suppresses glucose uptake for the competition of phosphotransferase system (PTS). Sublancin inhibits B. subtilis strain 168 ΔSPβ with MIC of 0.312 μM ^[2].

HY-P991750

*Anti-pan MHC Class II (HLA II) Antibody (IVA12)*	MHC	Inflammation/Immunology
Anti-pan MHC Class II (HLA II) Antibody (IVA12) recognizes human HLA-II (HLA-DR, HLA-DP, and HLA-DQ). Anti-pan MHC Class II (HLA II) Antibody (IVA12) blocks MHC-II in vitro. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .

HY-N7449R

Neamine (Standard)	Antibiotic Reference Standards Bacterial	Infection Cardiovascular Disease Neurological Disease Cancer
Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities ^[2].

HY-167256

Gentamicin C1	Antibiotic Bacterial	Infection
Gentamicin C1 is a broad-spectrum aminoglycoside antibiotic with antimicrobial activity .

HY-W775100

Spectinomycin sulfate	Antibiotic Bacterial	Infection
Spectinomycin sulfate is an aminocyclitol aminoglycoside antibiotic derived from Streptomyces spectabilis with bacteriostatic activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0490

Hygromycin B 35+ Cited Publications Hygrovetine	Infection Plant Cell Culture Microorganisms Antifungal Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Fungal Antibiotic Parasite
Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.

HY-17561

G-418 disulfate 60+ Cited Publications Geneticin sulfate; Antibiotic G-418 sulfate	Infection Plant Cell Culture Microorganisms Antifungal Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells .

HY-A0098

Tunicamycin 150+ Cited Publications	Structural Classification Antifungal Classification of Application Fields Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Antiviral Anticancer Inflammation/Immunology Disease Research Fields Source Classification	Antibiotic Influenza Virus Fungal Bacterial Aminotransferases (Transaminases) Exosomes
Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks *GlcNAc phosphotransferase* (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses** and has anti-cancer activity ^[2] .Tunicamycin increases exosome release in cervical cancer cells .

HY-B0470

Neomycin sulfate 65+ Cited Publications	Structural Classification Classification of Application Fields Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Phospholipase Bacterial
Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer ^[2].

HY-B1743

Puromycin Maximum Cited Publications 387 Publications Verification CL13900	Infection Structural Classification Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification	Bacterial Antibiotic Parasite
Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

HY-A0276

Gentamicin sulfate 60+ Cited Publications	Structural Classification Classification of Application Fields Antibacterial Disease Research Other Antibiotics Plant agriculture research Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Animal Husbandry Mammalian Cell Culture Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Bacterial
Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits DNase I with an IC₅₀ of 0.57 mM ^[2] .

HY-B1329

Apramycin sulfate 4 Publications Verification Nebramycin II sulfate	Microorganisms Classification of Application Fields Antibiotics Animal Husbandry Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	Bacterial Antibiotic
Apramycin (EBL 1003) sulfate is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin sulfate is a potential anti-drug-resistance antibiotic ^[2] .

HY-B0441

Tobramycin 15+ Cited Publications Nebramycin Factor 6; Deoxykanamycin B	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa ^[2] .

HY-B0472

Streptomycin sulfate 45+ Cited Publications	Structural Classification Classification of Application Fields Antibacterial Disease Research Other Antibiotics Plant agriculture research Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Bacterial
Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis.

HY-B1222

Sisomicin sulfate 5 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria.

HY-B1174

Bekanamycin Kanamycin B	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain ^[2].

HY-B0956

Paromomycin sulfate 4 Publications Verification Aminosidine sulfate	Classification of Application Fields Anti-parasitic Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Fields Source Classification	Antibiotic Parasite Bacterial
Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections ^[2] .

HY-125685

Germacrene D 1 Publications Verification	Classification of Application Fields Vigna mungo (L.) Hepper Plants Compositae Disease Research Fields Cancer	Bacterial Fungal
Germacrene D is isolated from Solidago canadensis. Germacrene D has antibacterial and antifungal activities and can be used as an adjuvant agent in the application of aminoglycosides and azoles .

HY-B1228

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic PDI
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum aminoglycoside Antibiotic with bactericidal activity against Gram-positive cocci, Gram-negative cocci, bacilli, and drug-resistant strains. Ribostamycin sulfate also acts as an inhibitor of protein disulfide isomerase (PDI), with a binding constant K_D of 319 μM for bovine PDI. Ribostamycin sulfate targets bacterial 16S ribosomal RNA and the 30S ribosomal subunit, causing translational misreading and thereby inhibiting bacterial protein synthesis. Ribostamycin sulfate disrupts the integrity of bacterial cell membranes, induces membrane pore formation, and leads to bacterial death. Ribostamycin sulfate can be used in studies related to bacterial infections ^[2] .

HY-B0441A

Tobramycin sulfate 15+ Cited Publications Nebramycin Factor 6 sulfate; Deoxykanamycin B sulfate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
Tobramycin (Nebramycin Factor 6) sulfate is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. Tobramycin sulfate can be used to pneumonia research caused by Pseudomonas aeruginosa ^[2] .

HY-B0856

Validamycin A 1 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Fungal Tyrosinase Antibiotic
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1?μg/mL . Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC₅₀ of 72 μM ^[2]. Validamycin A is a reversible tyrosinase inhibitor, with a K_i of 5.893 mM .

HY-N0818

Chikusetsusaponin Iva 2 Publications Verification Calenduloside F	Triterpenes Classification of Application Fields Terpenoids Other Diseases Amaranthaceae Plants Alternanthera philoxeroides (Mart.) Griseb. Disease Research Fields Source Classification	Keap1-Nrf2
Chikusetsusaponin IVa is an orally active protein kinase activator. Chikusetsusaponin IVa binds to YAP with a K_D value of 0.388 mM. Chikusetsusaponin IVa reduces inflammatory mediators (IL-6, IL-10, *COX-2) expression, NO production, promotes ROS* generation, induces Apoptosis, inhibits MAPK, TAZ, and regulates *Nrf2, JAK/STAT. Chikusetsusaponin Iva* has anti-H9N2 AIV and anti-endometrial cancer activities. Chikusetsusaponin Iva shows anti-inflammatory, hepatoprotective and osteoprotective effects ^[2] .

HY-N7449

Neamine	Infection Cardiovascular Disease Classification of Application Fields Disease Research Fields	Antibiotic Bacterial
Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities ^[2].

HY-142127

Ribostamycin 1 Publications Verification Vistamycin; SF-733	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic PDI
Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of PDI ^[2].

HY-105055

Didemnin B	Natural Products Animals Classification of Application Fields Marine natural products Other marine organisms Disease Research Fields Source Classification Cancer	Others
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-B1915

Micronomicin 1 Publications Verification Gentamicin C2b; Antibiotic XK-62-2; Sagamicin	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Fields Source Classification	Antibiotic Bacterial
Micronomicin (Gentamicin C2b) is an aminoglycoside antibiotic, with antibacterial and bactericidal activities .

HY-W006429

L-Uridine	Natural Products Classification of Application Fields Polyporaceae Metabolic Disease Poria cocos Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
L-Uridine is an enantiomer of the normal RNA constituent D-uridine. L-Uridine can be isolated from the Polyporaceae fungus Poria cocos (Schw.). L-uridine acts as a phosphate acceptor for nucleoside phosphotransferases ^[2].

HY-B0490R

Hygromycin B (Standard) Hygrovetine (Standard)	Structural Classification Plant Cell Culture Microorganisms Antifungal Antibiotics Resistance Selection Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Fungal Antibiotic Parasite
Hygromycin B (Standard) is the analytical standard of Hygromycin B. This product is intended for research and analytical applications. Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.

HY-108307

Micronomicin sulfate 1 Publications Verification Gentamicin C2b sulfate; Antibiotic XK-62-2 sulfate; Sagamicin sulfate	Infection Microorganisms Anti-inflammation/Immunoregulatory Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml) ^[2].

HY-17561R

G-418 disulfate (Standard) Geneticin sulfate (Standard); Antibiotic G-418 sulfate (Standard)	Structural Classification Plant Cell Culture Microorganisms Antifungal Antibiotics Resistance Selection Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic
G-418 (disulfate) (Standard) is the analytical standard of G-418 (disulfate). This product is intended for research and analytical applications. G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells[1].

HY-N6942

Mogroside IV-A	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Sweeteners Food Research Source Classification	Others
Mogroside IV-A, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities .

HY-N1465

Aristolochic acid D Aristolochic acid-IVa	Structural Classification Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Phenols Plants Disease Research Fields Source Classification Cancer	Phosphodiesterase (PDE) CDK Interleukin Related
Aristolochic acid D (Aristolochic acid-IVa) is an orally active *PDE2* (IC₅₀: 4.673 μM) and *CDK2* (IC₅₀: 25 μM) inhibitor that can be isolated from Aristolochia indica L. Aristolochic acid D exhibits anti-inflammatory activity and is non-carcinogenic and non-nephrotoxic. Aristolochic acid D can be used in the research of inflammation and tumor-related diseases ^[2] .

HY-N125722

Venturicidin A Aabomycin A1	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Source Classification	ATP Synthase Antibiotic
Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

HY-B1222A

Sisomicin 5 Publications Verification Antibiotic 6640; Rickamicin	Polysaccharides Microorganisms Saccharides Source Classification	Bacterial Antibiotic
Sisomicin is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is highly active against Gram-positive bacteria ^[2].

HY-B0470R

Neomycin sulfate (Standard)	Structural Classification Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Antibacterial Disease Research Anticancer Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic Phospholipase
Neomycin (sulfate) (Standard) is the analytical standard of Neomycin (sulfate). This product is intended for research and analytical applications. Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis ^[2].

HY-N14514

Gentamicin X2	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic
Gentamicin X2 is a minor aminoglycoside antibiotic component in the gentamicin complex .

HY-B1222R

Sisomicin sulfate (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic
Sisomicin (sulfate) (Standard) is the analytical standard of Sisomicin (sulfate). This product is intended for research and analytical applications. Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria ^[2] [4].

HY-N11857

Gentamicin C2	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Gentamicin C2 is an aminoglycoside antibiotic with broad-spectrum bactericidal activity, selectively binding to the bacterial 16S rRNA A-site. Gentamicin C2 interferes with protein synthesis initiation and translation fidelity to exert bactericidal effects. Gentamicin C2 can be used for the research of bacterial infections ^[2] .

HY-B0956A

Paromomycin Aminosidine	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Parasite Endogenous Metabolite
Paromomycin (Aminosidine) is an orally active broad-spectrum aminoglycoside aminocyclitol. Paromomycin is produced by Streptomyces riomosus var. Paromomycinus. Paromomycin binding induces local conformational changes in the 16S rRNA A-site. Paromomycin exhibits inhibitory activity against C. parvum. Paromomycin can be used in research related to leishmaniasis, amoebiasis and cryptosporidiosis ^[2] .

HY-B1329R

Apramycin sulfate (Standard) Nebramycin II sulfate (Standard)	Structural Classification Microorganisms Antibiotics Animal Husbandry Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic
Apramycin (sulfate) (Standard) is the analytical standard of Apramycin (sulfate). This product is intended for research and analytical applications. Apramycin (EBL 1003) is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin is a potential anti-drug-resistance antibiotic ^[2] .

HY-B0472R

Streptomycin sulfate (Standard)	Structural Classification Plant Cell Culture Microorganisms Antibiotics Resistance Selection Antibacterial Disease Research Other Antibiotics Plant agriculture research Source Classification	Reference Standards Bacterial Antibiotic
Streptomycin (sulfate) (Standard) is the analytical standard of Streptomycin (sulfate). This product is intended for research and analytical applications. Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis.

HY-Z16210

Nebramycin Ⅴ’ Nebramine factor 5′; 6′′-O-Carbamoyltobramycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Nebramycin V' (Nebramine factor 5′) is a multi-component aminoglycoside antibiotic with a broad-spectrum activity against Gram-positive and Gram-negative bacteria and mycobacteria .

HY-167256

Gentamicin C1	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Gentamicin C1 is a broad-spectrum aminoglycoside antibiotic with antimicrobial activity .

HY-W775100

Spectinomycin sulfate	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Spectinomycin sulfate is an aminocyclitol aminoglycoside antibiotic derived from Streptomyces spectabilis with bacteriostatic activity .

HY-B0441R

Tobramycin (Standard) Nebramycin Factor 6 (Standard); Deoxykanamycin B (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic
Tobramycin (Standard) is the analytical standard of Tobramycin. This product is intended for research and analytical applications. Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa ^[2] .

HY-N0818R

*Chikusetsusaponin Iva* (Standard)** Calenduloside F (Standard)	Triterpenes Structural Classification Terpenoids Amaranthaceae Plants Alternanthera philoxeroides (Mart.) Griseb. Source Classification	Reference Standards Others
Chikusetsusaponin Iva (Standard) is the analytical standard of Chikusetsusaponin Iva. This product is intended for research and analytical applications.

HY-N1465R

Aristolochic acid D (Standard) Aristolochic acid-IVa (Standard)	Monophenols other families Ketones, Aldehydes, Acids Phenols Plants Source Classification	Reference Standards CDK Phosphodiesterase (PDE) Interleukin Related
Aristolochic acid D (Standard) (Aristolochic acid-IVa (Standard)) is the analytical standard of Aristolochic acid D (HY-N1465). This product is intended for research and analytical applications. Aristolochic acid D (Aristolochic acid-IVa) is an orally active *PDE2* (IC₅₀: 4.673 μM) and *CDK2* (IC₅₀: 25 μM) inhibitor that can be isolated from Aristolochia indica L. Aristolochic acid D exhibits anti-inflammatory activity and is non-carcinogenic and non-nephrotoxic. Aristolochic acid D can be used in the research of inflammation and tumor-related diseases ^[2].

HY-N14386

Istamycin Y0	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Istamycin Y0 is an aminoglycoside antibiotic. Istamycin Y0 can be found in Streptomyces tenjimariensis ATCC 31603. Istamycin Y0 has only weak antibacterial activity against a few bacteria .

HY-B1915R

Micronomicin (Standard) Gentamicin C2b (Standard); Antibiotic XK-62-2 (Standard); Sagamicin (Standard)	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial Reference Standards
Micronomicin (Standard) is the analytical standard of Micronomicin. This product is intended for research and analytical applications. Micronomicin (Gentamicin C2b) is an aminoglycoside antibiotic, with antibacterial and bactericidal activities .

HY-121474

Dactimicin SF-2052	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Dactimicin is a pseudodisaccharide aminoglycoside. Dactimicin is an antibiotic that can inhibit the growth of methicillin-susceptible S. aureus isolates and coagulase-negative staphylococci with MIC₅₀s of 2 μg/mL. Dactimicin is active against organisms possessing aminoglycoside-modifying enzymes .

HY-N15127

3-O-Demethyl-2'-N-glylfortimicin B	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
3-O-Demethyl-2'-N-glylfortimicin B is an aminoglycoside antibiotic.

HY-N14341

Mannosyl glucosaminide	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Mannosyl glucosaminide is an aminoglycoside antibiotic. Mannosyl glucosaminide has anti-bacterium, mycobacterium and beer yeast effects .

HY-N14702

2-Hydroxygentamicin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
2-Hydroxygentamicin B is a 3 aminoglycoside antibiotic with anti-Gram-positive and negative bacteria activity .

HY-N14701

2-Hydroxygentamicin A3	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
2-Hydroxygentamicin A3 is a 3 aminoglycoside antibiotic with anti-Gram-positive and negative bacteria activity .

HY-N14703

2-Hydroxygentamicin B1	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
2-Hydroxygentamicin B1 is a 3 aminoglycoside antibiotic with anti-Gram-positive and negative bacteria activity .

Cat. No.	Product Name	Chemical Structure

HY-B1743S

Puromycin-d3 3 Publications Verification
Puromycin-d₃ is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

HY-W016456S

5-Bromopentanoic-3,3,4,4 Acid-d4
5-Bromopentanoic-3,3,4,4 Acid-d₄ is the deuterium labeled 5-Bromopentanoic-3,3,4,4 Acid (HY-W016456). 5-Bromopentanoic acid can be used for the synthesis of inhibitors for aminoglycoside resistant bacteria .

HY-17624S

Framycetin-d2

Framycetin-d₂ (Neomycin B-d₂) is the deuterium labeled Framycetin (HY-17624). Framycetin (Neomycin B), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a K_i of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibits hammerhead ribozyme with a K_i of 13.5 μM. Framycetin, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections.

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