Sisomicin sulfate

Name: Sisomicin sulfate
Brand: MedChemExpress
SKU: HY-B1222
Rating: 5.0 (5 reviews)

Cat. No.: HY-B1222 Purity: 99.15%: Data Sheet
SDS

COA
Handling Instructions
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Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria.

For research use only. We do not sell to patients.

Sisomicin sulfate Chemical Structure

CAS No. : 53179-09-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote
5 g	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Sisomicin sulfate:

Sisomicin Get quote
Sisomicin (sulfate) (Standard) Get quote

5 Publications Citing Use of MCE Sisomicin sulfate

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria.

IC₅₀ & Target

Aminoglycoside

In Vitro

Sisomicin sulfate (6.25 μg/mL) completely inhibits the growth of various clinical isolates bacterial, such as Klebsiella, Salmonella, Citrobacter, and Staphylococcus aureus^[1].
Sisomicin sulfate (20 μg/mL; 30 min) has insignificant impairment on polymorphonuclear neutrophil (PMN)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sisomicin sulfate (4 mg/kg; ip; single dose) appears to accumulate and persist in the kidneys, showing potential renal toxicity in rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

692.72

Formula

C₁₉H₃₇N₅O₇ . 5/2 H₂SO₄

CAS No.

53179-09-2

Appearance

Solid

Color

White to off-white

SMILES

N[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H]2O)([H])OC(CN)=CC1.[2.5H2SO4]

Structure Classification

Initial Source

Microorganisms

Micromonospora inyoensis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (180.45 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4436 mL	7.2179 mL	14.4358 mL
5 mM	0.2887 mL	1.4436 mL	2.8872 mL
10 mM	0.1444 mL	0.7218 mL	1.4436 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (144.36 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.15%

Select Batch:

Data Sheet (278 KB) SDS (479 KB)

COA (255 KB) HNMR (300 KB) LCMS (260 KB)

Handling Instructions (2659 KB)

References

[1]. P Noone, et al. Sisomicin, netilmicin and dibekacin. A review of their antibacterial activity and therapeutic use. Drugs. 1984 Jun;27(6):548-78. [Content Brief]

[2]. Crowe CC, et al. Sisomicin: evaluation in vitro and comparison with gentamicin and tobramycin. Antimicrob Agents Chemother. 1973 Jan;3(1):24-8. [Content Brief]

[3]. Le Moli S, et al. In vitro and in vivo effect of sisomicin and gentamycin on polymorphonuclear chemotaxis and phagocytosis. Int J Immunopharmacol. 1983;5(1):49-54. [Content Brief]

[4]. Fabre J, et al. Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats. Kidney Int. 1976 Dec;10(6):444-9.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4436 mL	7.2179 mL	14.4358 mL	36.0896 mL
	5 mM	0.2887 mL	1.4436 mL	2.8872 mL	7.2179 mL
	10 mM	0.1444 mL	0.7218 mL	1.4436 mL	3.6090 mL
	15 mM	0.0962 mL	0.4812 mL	0.9624 mL	2.4060 mL
	20 mM	0.0722 mL	0.3609 mL	0.7218 mL	1.8045 mL
	25 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.4436 mL
	30 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2030 mL
	40 mM	0.0361 mL	0.1804 mL	0.3609 mL	0.9022 mL
	50 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.7218 mL
	60 mM	0.0241 mL	0.1203 mL	0.2406 mL	0.6015 mL
	80 mM	0.0180 mL	0.0902 mL	0.1804 mL	0.4511 mL
	100 mM	0.0144 mL	0.0722 mL	0.1444 mL	0.3609 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.