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  3. Framycetin sulfate

Framycetin sulfate (Synonyms: Neomycin B sulfate; Fradiomycin B sulfate)

Cat. No.: HY-17624A
Handling Instructions

Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin sulfate, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections.

For research use only. We do not sell to patients.

Framycetin sulfate Chemical Structure

Framycetin sulfate Chemical Structure

CAS No. : 4146-30-9

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Description

Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin sulfate, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections[1][2].

IC50 & Target

Ki: 35 μM (RNase P cleavage activity) and 13.5 μM (hammerhead ribozyme)[1]

In Vitro

The inhibition of RNase P RNA cleavage by Framycetin sulfate (Neomycin Bsulfate; Fradiomycin Bsulfate) is sensitive to pH and an increase in pH suppresses the inhibition in other systems[1].
Framycetin sulfate targets the bacterial and human ribosome and affect translation. 5″-azido neomycin B and Framycetin sulfate selectively inhibit production of the mature miRNA, boosts a downstream protein, and inhibits invasion in HCC cell line[2].
Framycetin sulfate binds to a structural rather than a sequence motif of the RNA. Its primary cognate target is the decoding site of the 16S rRNA, but it also binds to the Rev-responsive element in HIV-1, group I introns, and the hammerhead ribozyme, and thus inhibits their biological function[3].
Framycetin sulfate induces misreading of the genetic code during translation and inhibits several ribozymes. The ribosomal target site is the 16 S rRNA 1400 to 1500 region[4].

Molecular Weight

908.88

Formula

C₂₃H₅₂N₆O₂₅S₃

CAS No.

4146-30-9

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FramycetinNeomycin BFradiomycin BBacterialantibioticRNasePcleavagedivalentmetalionhammerheadribozyme5″-azidoneomycinBDroshamiR-525hepaticencephalopathyE.coliInhibitorinhibitorinhibit

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Framycetin sulfate
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HY-17624A
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