2. Anti-infection
  3. Antibiotic Bacterial
  4. Gentamicin C2

Gentamicin C2 is an aminoglycoside antibiotic with broad-spectrum bactericidal activity, selectively binding to the bacterial 16S rRNA A-site. Gentamicin C2 interferes with protein synthesis initiation and translation fidelity to exert bactericidal effects. Gentamicin C2 can be used for the research of bacterial infections.

For research use only. We do not sell to patients.

Gentamicin C2

Gentamicin C2 Chemical Structure

CAS No. : 25876-11-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Gentamicin C2 Related Antibodies

Top Publications Citing Use of Products

View All Antibiotic Isoform Specific Products:

View All Isoforms
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gentamicin C2 is an aminoglycoside antibiotic with broad-spectrum bactericidal activity, selectively binding to the bacterial 16S rRNA A-site. Gentamicin C2 interferes with protein synthesis initiation and translation fidelity to exert bactericidal effects. Gentamicin C2 can be used for the research of bacterial infections[1][2][3].

Parmacokinetics
Species Dose Route AUC0-∞ CL Vss MRT T1/2
Dog[2] 2 mg/kg i.v. 41820 μg·h/mL 1.82 mL/min/kg 0.15 L/kg 84 min 66 min
In Vivo

Gentamicin C2 (1.984 mg/kg; i.v.; single bolus) has a total body clearance of 1.82 mL·min−1·kg−1, volume of distribution at steady state of 0.15 liter/kg, mean residence time of 84 min, and terminal half-life of 66 min in healthy beagle dogs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Beagle (4 males, 2 females, 16-20 kg)[2]
Dosage: 1.984 mg/kg
Administration: i.v.; single bolus
Result: Achieved a mean area under the plasma concentration-time curve (AUC) of 697 μg·mL-1·min.
Reached a total body clearance (CL) of 1.82 mL·min-1·kg-1.
Attained a volume of distribution at steady state (Vss) of 0.15 liter/kg.
Had a mean residence time (MRT) of 84 min.
Exhibited a terminal half-life (t1/2) of 66 min.
Showed an elimination rate constant (β) of 0.011 min-1.
Reached a volume of distribution in the elimination phase (Vβ) of 0.17 liter/kg.
Demonstrated statistically significant differences in CL, Vss, and Vβ compared to Gentamicin C1 (P = 0.0156).
Showed no statistically significant differences in any parameters compared to Gentamicin C1a.
Had no differences in MRT and t1/2 compared to Gentamicin C1 and Gentamicin C1a.
Molecular Weight

463.57

Formula

C20H41N5O7
CAS No.
SMILES

O[C@@H]([C@@H]1O[C@H]([C@@H](CC2)N)O[C@]2([H])[C@H](N)C)[C@H]([C@@H](C[C@@H]1N)N)O[C@@H](OC[C@@]3(O)C)[C@@H]([C@H]3NC)O
Structure Classification
Initial Source

Micromonospora spp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Gentamicin C2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gentamicin C225876-11-3Gentamicin C 2Gentamicin C-2AntibioticBacterialGenB1protein synthesis initiationZL10116S rRNA A-sitebeaglesbacterial infectionsbeagle dogsGenB2glomerular filtrationtranslation fidelityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Gentamicin C2
Cat. No.:
HY-N11857
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.