Plazomicin sulfate
Based on 1 publication(s) in Google Scholar
Plazomicin (ACHN 490) sulfate is a semi-synthetic aminoglycoside Antibiotic. Plazomicin sulfate acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin sulfaten is not modified by various common aminoglycoside-modifying enzymes. Plazomicin sulfate selectively inhibits MATE2-K. Plazomicin sulfate exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 1380078-95-4
- Formula: C25H48N6O10·5/2H2SO4
- Molecular Weight:837.87
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Plazomicin sulfate
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Biological Activity
Description
In Vitro
Plazomicin sulfate exhibits MIC50/90 = 0.25-0.5 μg/mL/0.5-1 μg/mL Against Klebsiella, Escherichia, Enterobacter, Serratia, and Citrobacter species[1].
Plazomicin sulfate selectively inhibits MATE2-K and to a lesser extent MATE1, and OCT2, which are important transporters involved with tubular secretion[1].
Plazomicin (18 h) sulfate retains antibacterial activity against most aminoglycoside modifying enzyme-expressing E. coli BW25113 and E. coli BW25113 ΔbamB ΔtolC strains[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1380078-95-4
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Appearance Solid
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Molecular Weight 837.87
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Formula C25H48N6O10·5/2H2SO4
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Color White to off-white
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SMILES
O[C@H]([C@H]([C@@](C)(O)CO1)NC)[C@@]1([H])O[C@H]2[C@@H](C[C@H](N)[C@@H](O[C@@]3([H])OC(CNCCO)=CC[C@H]3N)[C@@H]2O)NC([C@@H](O)CCN)=O.OS(O)(=O)=O.[2.5]
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Synonyms
ACHN 490 sulfate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL (119.35 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (291 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Clark JA, et al. Plazomicin: a new aminoglycoside in the fight against antimicrobial resistance. Ther Adv Infect Dis. 2020;7:2049936120952604. Published 2020 Sep 4. [Content Brief]
[2]. Cox G, et al. Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes. ACS Infect Dis. 2018;4(6):980-987. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.1935 mL | 5.9675 mL | 11.9350 mL | 29.8376 mL |
| 5 mM | 0.2387 mL | 1.1935 mL | 2.3870 mL | 5.9675 mL | |
| 10 mM | 0.1194 mL | 0.5968 mL | 1.1935 mL | 2.9838 mL | |
| 15 mM | 0.0796 mL | 0.3978 mL | 0.7957 mL | 1.9892 mL | |
| 20 mM | 0.0597 mL | 0.2984 mL | 0.5968 mL | 1.4919 mL | |
| 25 mM | 0.0477 mL | 0.2387 mL | 0.4774 mL | 1.1935 mL | |
| 30 mM | 0.0398 mL | 0.1989 mL | 0.3978 mL | 0.9946 mL | |
| 40 mM | 0.0298 mL | 0.1492 mL | 0.2984 mL | 0.7459 mL | |
| 50 mM | 0.0239 mL | 0.1194 mL | 0.2387 mL | 0.5968 mL | |
| 60 mM | 0.0199 mL | 0.0995 mL | 0.1989 mL | 0.4973 mL | |
| 80 mM | 0.0149 mL | 0.0746 mL | 0.1492 mL | 0.3730 mL | |
| 100 mM | 0.0119 mL | 0.0597 mL | 0.1194 mL | 0.2984 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Plazomicin sulfate Related Classifications
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