2. Anti-infection
  3. Antibiotic Bacterial
  4. Plazomicin sulfate

Plazomicin sulfate  (Synonyms: ACHN 490 sulfate)

Cat. No.: HY-16955A Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

Plazomicin (ACHN 490) sulfate is a semi-synthetic aminoglycoside Antibiotic. Plazomicin sulfate acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin sulfaten is not modified by various common aminoglycoside-modifying enzymes. Plazomicin sulfate selectively inhibits MATE2-K. Plazomicin sulfate exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales.

For research use only. We do not sell to patients.

Plazomicin sulfate

Plazomicin sulfate Chemical Structure

CAS No. : 1380078-95-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water In-stock
Solid
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Based on 1 publication(s) in Google Scholar

Other Forms of Plazomicin sulfate:

Plazomicin sulfate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Plazomicin sulfate

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Description

Plazomicin (ACHN 490) sulfate is a semi-synthetic aminoglycoside Antibiotic. Plazomicin sulfate acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin sulfaten is not modified by various common aminoglycoside-modifying enzymes. Plazomicin sulfate selectively inhibits MATE2-K. Plazomicin sulfate exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales[1][2].

In Vitro

Plazomicin sulfate exhibits MIC50/90 = 0.25-0.5 μg/mL/0.5-1 μg/mL Against Klebsiella, Escherichia, Enterobacter, Serratia, and Citrobacter species[1].
Plazomicin sulfate selectively inhibits MATE2-K and to a lesser extent MATE1, and OCT2, which are important transporters involved with tubular secretion[1].
Plazomicin (18 h) sulfate retains antibacterial activity against most aminoglycoside modifying enzyme-expressing E. coli BW25113 and E. coli BW25113 ΔbamB ΔtolC strains[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Plazomicin sulfate Related Antibodies
Clinical Trial
Molecular Weight

935.94

Formula

C25H48N6O10.5/2H2SO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@H]([C@@](C)(O)CO1)NC)[C@@]1([H])O[C@H]2[C@@H](C[C@H](N)[C@@H](O[C@@]3([H])OC(CNCCO)=CC[C@H]3N)[C@@H]2O)NC([C@@H](O)CCN)=O.OS(O)(=O)=O.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (106.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0684 mL 5.3422 mL 10.6844 mL
5 mM 0.2137 mL 1.0684 mL 2.1369 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.0%

SDS (393 KB)

COA (257 KB) HNMR (355 KB) MS (70 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0684 mL 5.3422 mL 10.6844 mL 26.7111 mL
5 mM 0.2137 mL 1.0684 mL 2.1369 mL 5.3422 mL
10 mM 0.1068 mL 0.5342 mL 1.0684 mL 2.6711 mL
15 mM 0.0712 mL 0.3561 mL 0.7123 mL 1.7807 mL
20 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.3356 mL
25 mM 0.0427 mL 0.2137 mL 0.4274 mL 1.0684 mL
30 mM 0.0356 mL 0.1781 mL 0.3561 mL 0.8904 mL
40 mM 0.0267 mL 0.1336 mL 0.2671 mL 0.6678 mL
50 mM 0.0214 mL 0.1068 mL 0.2137 mL 0.5342 mL
60 mM 0.0178 mL 0.0890 mL 0.1781 mL 0.4452 mL
80 mM 0.0134 mL 0.0668 mL 0.1336 mL 0.3339 mL
100 mM 0.0107 mL 0.0534 mL 0.1068 mL 0.2671 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Plazomicin sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Plazomicin1380078-95-4ACHN 490ACHN490ACHN-490AntibioticBacterialAminoglycosideantimicrobialcarbapenemEnterobacteriaceaecomplicated urinary tract infectionscUTIsInhibitorinhibitorinhibit

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