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  3. Micronomicin sulfate

Micronomicin sulfate (Synonyms: Gentamicin C2b sulfate; Antibiotic XK-62-2 sulfate; Sagamicin sulfate)

Cat. No.: HY-108307 Purity: ≥98.0%
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Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml).

For research use only. We do not sell to patients.

Micronomicin sulfate Chemical Structure

Micronomicin sulfate Chemical Structure

CAS No. : 66803-19-8

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50 mg USD 45 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml)[1][2].

IC50 & Target

MIC: 0.001-8.3 μg/ml (Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia)[2]

In Vitro

Micronomicin has a potent antibacterial activity, it is active against Staphylococcus aureus FDA 209 P, Staphylococcus aureus with the minimal inhibitory values of 0.01 μg/ml. It is also against Escherichia coli St.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active against Pseudomonas aeruginosa strains and lebsiella pneumoniae strains (MICs = 0.03-17.5 μg/ml)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD50 in mice of 93 mg/kg[1].
Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats[3]
Dosage: 4, 10, 25, 63 mg/kg and 100 mg/kg
Administration: Intravenous injection; 30 days
Result: Led to death of rat at 100 mg/kg.
Formula

C₂₀H₄₁N₅O₇.xH₂O₄S

CAS No.

66803-19-8

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

References
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Keywords:

MicronomicinGentamicin C2bAntibiotic XK-62-2SagamicinAntibioticBacterialStaphylococcus aureusBacillus subtilisEscherichia coliBaker 2F 14-BKand R5/W677bacterialinfectionInhibitorinhibitorinhibit

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Micronomicin sulfate
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HY-108307
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