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  2. Antibiotic
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  3. Micronomicin sulfate

Micronomicin sulfate (Synonyms: Gentamicin C2b sulfate; Antibiotic XK-62-2 sulfate; Sagamicin sulfate)

Cat. No.: HY-108307
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Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml).

For research use only. We do not sell to patients.

Micronomicin sulfate Chemical Structure

Micronomicin sulfate Chemical Structure

CAS No. : 66803-19-8

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Description

Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml)[1][2].

IC50 & Target

MIC: 0.001-8.3 μg/ml (Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia)[2]

In Vitro

Micronomicin has a potent antibacterial activity, it is active against Staphylococcus aureus FDA 209 P, Staphylococcus aureus with the minimal inhibitory values of 0.01 μg/ml. It is also against Escherichia coli St.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active against Pseudomonas aeruginosa strains and lebsiella pneumoniae strains (MICs = 0.03-17.5 μg/ml)[1].

In Vivo

Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD50 in mice of 93 mg/kg[1].
Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over[3].

Animal Model: Wistar rats[3]
Dosage: 4, 10, 25, 63 mg/kg and 100 mg/kg
Administration: Intravenous injection; 30 days
Result: Led to death of rat at 100 mg/kg.
Formula

C₂₀H₄₁N₅O₇.xH₂O₄S

CAS No.

66803-19-8

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MicronomicinGentamicin C2bAntibiotic XK-62-2SagamicinAntibioticBacterialStaphylococcus aureusBacillus subtilisEscherichia coliBaker 2F 14-BKand R5/W677bacterialinfectionInhibitorinhibitorinhibit

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Micronomicin sulfate
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