2. Validamycin A

Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM.

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Validamycin A Chemical Structure

Validamycin A Chemical Structure

CAS No. : 37248-47-8

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Solid + Solvent
10 mM * 1 mL in Water
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Validamycin A Related Antibodies

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Description

Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL[1]. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM[2]. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM[3].

IC50 & Target

Antibiotic[1], IC50: 72 μM (trehalase)[2], Ki: 5.893 mM (tyrosinase)[3]
In Vitro

Validamycin A (0.5-1 μg/mL; 18 hours) inhibits the growth of A. flavus and delayed conidial germination[1].
? Validamycin A shows no cytotoxicity to human bronchial epithelial cells[1].
? Validamycin A directly binds to several residues in the active site of tyrosinase, including HIS85, HIS244, GLU256, HIS259 and ASN260[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Validamycin A Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Aspergillus flavus ATCC204304
Concentration: 0.5 μg/mL, 1 μg/mL
Incubation Time: 18 hours
Result: Inhibited the growth of Aspergillus flavus.
Molecular Weight

497.49

Formula

C20H35NO13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](N[C@H]2C=C(CO)[C@@H](O)[C@H](O)[C@H]2O)C[C@H](CO)[C@@H](O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)[C@@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (251.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0101 mL 10.0505 mL 20.1009 mL
5 mM 0.4020 mL 2.0101 mL 4.0202 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (201.01 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0101 mL 10.0505 mL 20.1009 mL 50.2523 mL
5 mM 0.4020 mL 2.0101 mL 4.0202 mL 10.0505 mL
10 mM 0.2010 mL 1.0050 mL 2.0101 mL 5.0252 mL
15 mM 0.1340 mL 0.6700 mL 1.3401 mL 3.3502 mL
20 mM 0.1005 mL 0.5025 mL 1.0050 mL 2.5126 mL
25 mM 0.0804 mL 0.4020 mL 0.8040 mL 2.0101 mL
30 mM 0.0670 mL 0.3350 mL 0.6700 mL 1.6751 mL
40 mM 0.0503 mL 0.2513 mL 0.5025 mL 1.2563 mL
50 mM 0.0402 mL 0.2010 mL 0.4020 mL 1.0050 mL
60 mM 0.0335 mL 0.1675 mL 0.3350 mL 0.8375 mL
80 mM 0.0251 mL 0.1256 mL 0.2513 mL 0.6282 mL
100 mM 0.0201 mL 0.1005 mL 0.2010 mL 0.5025 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Validamycin A37248-47-8Inhibitorinhibitorinhibit

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