1. Anti-infection
    Metabolic Enzyme/Protease
  2. Fungal
    Tyrosinase
  3. Validamycin A

Validamycin A 

Cat. No.: HY-B0856 Purity: >60.0%
Handling Instructions

Validamycin A is an aminoglycoside agricultural antibiotic. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM.

For research use only. We do not sell to patients.

Validamycin A Chemical Structure

Validamycin A Chemical Structure

CAS No. : 37248-47-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Validamycin A is an aminoglycoside agricultural antibiotic. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL[1]. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM[2].

IC50 & Target

Ki: 5.893 mM (tyrosinase)[2]

In Vitro

Validamycin A (0.5-1 μg/mL; 18 hours) inhibits the growth of A. flavus and delayed conidial germination[1].
Validamycin A shows no cytotoxicity to human bronchial epithelial cells[1].
Validamycin A binds directly to several residues in the active site of tyrosinase, including HIS85, HIS244, GLU256, HIS259 and ASN260[1].

Cell Proliferation Assay[1]

Cell Line: Aspergillus flavus ATCC204304
Concentration: 0.5 μg/mL, 1 μg/mL
Incubation Time: 18 hours
Result: Inhibited the growth of Aspergillus flavus.
Molecular Weight

497.49

Formula

C₂₀H₃₅NO₁₃

CAS No.

37248-47-8

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (251.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0101 mL 10.0505 mL 20.1009 mL
5 mM 0.4020 mL 2.0101 mL 4.0202 mL
10 mM 0.2010 mL 1.0050 mL 2.0101 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Validamycin AFungalTyrosinaseaminoglycosideagriculturalantibiotictyrosinaseantimicrobialantifungalAspergillusflavusInhibitorinhibitorinhibit

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Validamycin A
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