Validamycin A
Based on 1 publication(s) in Google Scholar
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1?μg/mL. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM.
For research use only. We do not sell to patients.
- Purity: 60.0%
- CAS No.: 37248-47-8
- Formula: C20H35NO13
- Molecular Weight:497.49
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Validamycin A
MoreAll Antibiotic Isoforms
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Biological Activity
Antibiotic[1], IC50: 72 μM (trehalase)[2], Ki: 5.893 mM (tyrosinase)[3]
Validamycin A (0.5-1 μg/mL; 18 hours) inhibits the growth of A. flavus and delayed conidial germination[1].
Validamycin A shows no cytotoxicity to human bronchial epithelial cells[1].
Validamycin A directly binds to several residues in the active site of tyrosinase, including HIS85, HIS244, GLU256, HIS259 and ASN260[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Aspergillus flavus ATCC204304
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Concentration:0.5 μg/mL, 1 μg/mL
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Incubation Time:18 hours
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Result:Inhibited the growth of Aspergillus flavus.
Chemical Information
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CAS No. 37248-47-8
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Appearance Solid
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Molecular Weight 497.49
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Formula C20H35NO13
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Color White to off-white
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SMILES
O[C@H]1[C@@H](N[C@H]2C=C(CO)[C@@H](O)[C@H](O)[C@H]2O)C[C@H](CO)[C@@H](O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)[C@@H]1O
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Structure Classification
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Initial Source
Streptomyces hygroscopicus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Pest Manag Sci
Trehalose metabolism mediates trade-offs between reproduction and survival in beet webworm, Loxostege sticticalis, under heat stress. [Abstract]2025 Feb;81(2):903-911. PMID: 39435696
Solvent & Solubility
H2O : 125 mg/mL (251.26 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (201.01 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Napasawan Plabutong, et al. The Inhibitory Effect of Validamycin A on Aspergillus flavus. Int J Microbiol. 2020; 2020: 3972415. [Content Brief]
[2]. N Asano, et al. Effect of validamycins on glycohydrolases of Rhizoctonia solani. J Antibiot (Tokyo). 1987 Apr;40(4):526-32. [Content Brief]
[3]. Zhi-Jiang Wang, et al. The effect of validamycin A on tyrosinase: inhibition kinetics and computational simulation. Int J Biol Macromol. 2013 Apr;55:15-23. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.0101 mL | 10.0505 mL | 20.1009 mL | 50.2523 mL |
| 5 mM | 0.4020 mL | 2.0101 mL | 4.0202 mL | 10.0505 mL | |
| 10 mM | 0.2010 mL | 1.0050 mL | 2.0101 mL | 5.0252 mL | |
| 15 mM | 0.1340 mL | 0.6700 mL | 1.3401 mL | 3.3502 mL | |
| 20 mM | 0.1005 mL | 0.5025 mL | 1.0050 mL | 2.5126 mL | |
| 25 mM | 0.0804 mL | 0.4020 mL | 0.8040 mL | 2.0101 mL | |
| 30 mM | 0.0670 mL | 0.3350 mL | 0.6700 mL | 1.6751 mL | |
| 40 mM | 0.0503 mL | 0.2513 mL | 0.5025 mL | 1.2563 mL | |
| 50 mM | 0.0402 mL | 0.2010 mL | 0.4020 mL | 1.0050 mL | |
| 60 mM | 0.0335 mL | 0.1675 mL | 0.3350 mL | 0.8375 mL | |
| 80 mM | 0.0251 mL | 0.1256 mL | 0.2513 mL | 0.6282 mL | |
| 100 mM | 0.0201 mL | 0.1005 mL | 0.2010 mL | 0.5025 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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