Dihydrostreptomycin sulfate
Based on 1 Customer Validation
Dihydrostreptomycin sulfate (DHSM sulfate) is the sulfate salt form of Dihydrostreptomycin (HY-B1241A). Dihydrostreptomycin sulfate is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin sulfate exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss.
For research use only. We do not sell to patients.
- Purity: 99.68%
- CAS No.: 5490-27-7
- Formula: C21H41N7O12 . 3/2 H2SO4
- Molecular Weight:730.71
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Antibiotic Isoforms
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Biological Activity
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Aminoglycoside |
Dihydrostreptomycin sulfate blocks mechanoelectric transduction channels, induces increased intracellular calcium concentrations, and leads to the obstruction of auditory signal transmission[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse models[2]
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Dosage:600 mg/kg
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Administration:ip, once daily for 12 days
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Result:Upregulated the expression of FGF receptors and connexin 43, increased the number of BrdU-positive cells in the spiral ligament.
Chemical Information
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CAS No. 5490-27-7
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Appearance Solid
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Molecular Weight 730.71
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Formula C21H41N7O12 . 3/2 H2SO4
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Color White to off-white
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SMILES
O[C@@H]1[C@@H](O)[C@@](O[C@@H]2O[C@@H](C)[C@](O)(CO)[C@H]2O[C@@]3([H])[C@@H](NC)[C@H](O)[C@@H](O)[C@H](CO)O3)([H])[C@@H](NC(N)=N)[C@H](O)[C@H]1NC(N)=N.[1.5H2SO4]
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Synonyms
DHSM sulfate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 250 mg/mL (342.13 mM; Need ultrasonic)
DMSO : 5.83 mg/mL (7.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (136.85 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (281 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. Marcotti W, et al. The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J Physiol. 2005 Sep 1;567(Pt 2):505-21. [Content Brief]
[2]. Yamashita H, et al., Cell proliferation in spiral ligament of mouse cochlea damaged by dihydrostreptomycin sulfate. Acta Otolaryngol. 1999;119(3):322-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.3685 mL | 6.8427 mL | 13.6853 mL | 34.2133 mL |
| 5 mM | 0.2737 mL | 1.3685 mL | 2.7371 mL | 6.8427 mL | |
| H2O | 10 mM | 0.1369 mL | 0.6843 mL | 1.3685 mL | 3.4213 mL |
| 15 mM | 0.0912 mL | 0.4562 mL | 0.9124 mL | 2.2809 mL | |
| 20 mM | 0.0684 mL | 0.3421 mL | 0.6843 mL | 1.7107 mL | |
| 25 mM | 0.0547 mL | 0.2737 mL | 0.5474 mL | 1.3685 mL | |
| 30 mM | 0.0456 mL | 0.2281 mL | 0.4562 mL | 1.1404 mL | |
| 40 mM | 0.0342 mL | 0.1711 mL | 0.3421 mL | 0.8553 mL | |
| 50 mM | 0.0274 mL | 0.1369 mL | 0.2737 mL | 0.6843 mL | |
| 60 mM | 0.0228 mL | 0.1140 mL | 0.2281 mL | 0.5702 mL | |
| 80 mM | 0.0171 mL | 0.0855 mL | 0.1711 mL | 0.4277 mL | |
| 100 mM | 0.0137 mL | 0.0684 mL | 0.1369 mL | 0.3421 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Dihydrostreptomycin sulfate Related Classifications
HY-B1241 Related Classifications
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