1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Sarafloxacin hydrochloride

Sarafloxacin hydrochloride (Synonyms: A-56620 hydrochloride)

Cat. No.: HY-B0343A Purity: 98.38%
Handling Instructions

Sarafloxacin (hydrochloride) (A-56620 (hydrochloride)) is a quinolone antibiotic drug.

For research use only. We do not sell to patients.

Sarafloxacin hydrochloride Chemical Structure

Sarafloxacin hydrochloride Chemical Structure

CAS No. : 91296-87-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
500 mg USD 70 In-stock
Estimated Time of Arrival: December 31
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Description

Sarafloxacin (hydrochloride) (A-56620 (hydrochloride)) is a quinolone antibiotic drug.

IC50 & Target

Antibacterial[1].

In Vitro

Sarafloxacin (hydrochloride) is a fluoroquinolone antibiotic registered for use against poultry diseases. Sarafloxacin treatment demonstrated mineralization to 14CO2 amounting to 0.58%, 0.49%, and 0.57% in loam, silt loam, and sandy loam soils, respectively, at the termination of the test[1]. The inhibitory level of sarafloxacin for the tested bacteria was strain dependent. It appeared that in broth culture Escherichia coli isolates were sensitive to sarafloxacin concentrations 5-fold lower than the concentrations present in the simulated gut model, suggesting that sarafloxacin may be partially unavailable due to absorption to organic matter in the model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Administering Sarafloxacin (hydrochloride) in the feed for 5 d at a dose of 10 or 12.5 mg/kg of fish proved efficacious in treating channel catfish infected with E. ictaluri in all three field trials. Average survival of the nonmedicated group was 43% in trial 1, 11°% in trial 2, and 59% in trial 3. Survival of the corresponding Sarafloxacin hydrochloride-medicated groups averaged 68, 48, and 73%. Antibiotic therapy with Sarafloxacin hydrochloride significantly (P < 0.05) improved survival in all trials[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

421.83

Formula

C₂₀H₁₈ClF₂N₃O₃

CAS No.
SMILES

O=C(C1=CN(C2=CC=C(F)C=C2)C3=C(C=C(F)C(N4CCNCC4)=C3)C1=O)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (19.75 mM; Need ultrasonic)

H2O : 1 mg/mL (2.37 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3706 mL 11.8531 mL 23.7062 mL
5 mM 0.4741 mL 2.3706 mL 4.7412 mL
10 mM 0.2371 mL 1.1853 mL 2.3706 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (1.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (1.97 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (1.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.38%

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Keywords:

SarafloxacinA-56620A56620A 56620BacterialAntibioticInhibitorinhibitorinhibit

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Sarafloxacin hydrochloride
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HY-B0343A
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