Cat. No.: HY-14814

Delafloxacin

(Synonyms: RX-3341; WQ-3034; ABT492)

6 Cited Publications

Customer Review

Based on 6 publication(s) in Google Scholar

Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia.

For research use only. We do not sell to patients.

Purity: 99.90%
CAS No.: 189279-58-1
Formula: C₁₈H₁₂ClF₃N₄O₄
Molecular Weight:440.76

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Delafloxacin Chemical Structure

CAS No.: 189279-58-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Publications (6)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Quinolone

All Antibiotic Isoforms :

In Vivo

Delafloxacin (the total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection) is highly effective against S. aureus. Against all four strains are observed a decrease of 1.5 to 2.2 log₁₀ CFU in organism burden from untreated controls at even the lowest dose studied, and for two strains (MW2 and R2527) there is net bactericidal activity at the lowest dose. At the maximal doses studied, there is a >4-log₁₀ kill from initial burden for all S. aureus strains^[1].
Delafloxacin (2.5, 10, 40, and 160 mg/kg; subcutaneous injection, 24 h) has moderate terminal elimination half-life (t_1/2=0.68 h, 0.79 h, 0.69 h and 1.0 h for 2.5 mg/kg, 10 mg/kg, 40 mg/kg, and 160 mg/kg, respectively)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice with a neutropenic murine lung infection model (four S. aureus , four S. pneumoniae, and four K. pneumoniae strains)^[1]
Dosage:

The total daily doses vary from 0.156 to 640 mg/kg/24 h
Administration:

0.03 to 160 mg/kg are administered every 6 h (q6h) to infected mice by subcutaneous injection
Result:

Inhibited S. aureus strains ATCC 29213, ATCC 33591, MW2, R2527 with MICs of 0.008, 0.008, 0.004, and 0.004 mg/L, respectively.
Inhibited S. pneumoniae strains ATCC 10813, ATCC 49619, 145, and 1329 with MICs of 0.03, 0.125, 0.016, and 0.016 mg/L, respectively.
Inhibited K. pneumonia strains ATCC 43816, 4105, 4110, and 81-1260A with MICs of 0.06, 1, 0.5, and 0.06 mg/L, respectively.

Animal Model:

Neutropenic mice^[1]
Dosage:

2.5, 10, 40, and 160 mg/kg; 0.2 mL
Administration:

Subcutaneous injection; 24 h
Result:

The maximum drug concentrations (C_max) concentrations ranged from 2 to 71 mg/L. AUC_0-∞ values ranged from 2.8 to 152 mg•h/L and were linear across the 2.5- to 160-mg dosing range. The elimination half-life (t_1/2) ranged from 0.7 to 1 h.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 189279-58-1
Appearance Solid
Molecular Weight 440.76
Formula C₁₈H₁₂ClF₃N₄O₄
Color Off-white to light yellow
SMILES

O=C(C1=CN(C2=NC(N)=C(F)C=C2F)C3=C(C=C(F)C(N4CC(O)C4)=C3Cl)C1=O)O
Synonyms

RX-3341; WQ-3034; ABT492
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (6)

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Journal Impact Factor

Nat Microbiol

Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains. [Abstract]

2023 Mar;8(3):410-423. PMID: 36759752
Mater Today Commun

2026 Jun 16;54:115566.
Antimicrob Agents Chemother

In Vitro and In Vivo Properties of CUO246, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor. [Abstract]

2022 Dec 20;66(12):e0092122. PMID: 36448795
Microbiol Spectr

Effect of pH on antimicrobial activity of delafloxacin against Escherichia coli isogenic strains carrying diverse chromosomal and plasmid-mediated fluoroquinolone resistance mechanisms. [Abstract]

2025 Oct 30:e0233825. PMID: 41165356
Pathology

In vitro activity of recently introduced Gram-positive-specific antimicrobial agents against Australian methicillin-resistant Staphylococcus aureus isolates. [Abstract]

2026 Feb 6:S0031-3025(26)00393-4. PMID: 41760492
J Glob Antimicrob Resist

Susceptibility of multidrug-resistant Escherichia coli and Klebsiella pneumoniae to oral antibiotics in Australia. [Abstract]

2025 Aug 8:44:435-441. PMID: 40784378

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (226.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2688 mL

11.3440 mL

22.6881 mL

5 mM

0.4538 mL

2.2688 mL

4.5376 mL

10 mM

0.2269 mL

1.1344 mL

2.2688 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lepak AJ, et al. In Vivo Pharmacodynamic Target Assessment of Delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a Murine Lung Infection Model. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4764-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2688 mL	11.3440 mL	22.6881 mL	56.7202 mL
	5 mM	0.4538 mL	2.2688 mL	4.5376 mL	11.3440 mL
	10 mM	0.2269 mL	1.1344 mL	2.2688 mL	5.6720 mL
	15 mM	0.1513 mL	0.7563 mL	1.5125 mL	3.7813 mL
	20 mM	0.1134 mL	0.5672 mL	1.1344 mL	2.8360 mL
	25 mM	0.0908 mL	0.4538 mL	0.9075 mL	2.2688 mL
	30 mM	0.0756 mL	0.3781 mL	0.7563 mL	1.8907 mL
	40 mM	0.0567 mL	0.2836 mL	0.5672 mL	1.4180 mL
	50 mM	0.0454 mL	0.2269 mL	0.4538 mL	1.1344 mL
	60 mM	0.0378 mL	0.1891 mL	0.3781 mL	0.9453 mL
	80 mM	0.0284 mL	0.1418 mL	0.2836 mL	0.7090 mL
	100 mM	0.0227 mL	0.1134 mL	0.2269 mL	0.5672 mL

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Delafloxacin

Anti-Infection Compound Library

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Drug Repurposing Compound Library

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FDA Approved & Pharmacopeial Drug Library

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Human Metabolite Library

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Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) Delafloxacin

All Antibiotic Isoforms

Biological Activity

Chemical Information

Publications (6)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Delafloxacin

Anti-Infection Compound Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Antibacterial Compound Library

FDA Approved & Pharmacopeial Drug Library

Antibiotics Library

EMA-Approved Drug Library

Human Metabolite Library

Off-patent Drug Library

Anti-Drug-Resistant Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) Delafloxacin

All Antibiotic Isoforms

Biological Activity

Chemical Information

Publications (6)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Delafloxacin Related Classifications

HY-14814 Related Classifications