1. Anti-infection
  2. Bacterial

Delafloxacin meglumine (Synonyms: ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine)

Cat. No.: HY-14814A Purity: 99.98%
Handling Instructions

Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia.

For research use only. We do not sell to patients.

Delafloxacin meglumine Chemical Structure

Delafloxacin meglumine Chemical Structure

CAS No. : 352458-37-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 252 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
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10 mg USD 336 In-stock
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50 mg USD 1020 In-stock
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100 mg USD 1680 In-stock
Estimated Time of Arrival: December 31
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Other Forms of Delafloxacin meglumine:

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  • Technical Information

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  • References

Description

Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia[1].

IC50 & Target

Antibiotic[1]

In Vivo

Delafloxacin (the total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection) is highly effective against S. aureus. Against all four strains are observed a decrease of 1.5 to 2.2 log10 CFU in organism burden from untreated controls at even the lowest dose studied, and for two strains (MW2 and R2527) there is net bactericidal activity at the lowest dose. At the maximal doses studied, there is a >4-log10 kill from initial burden for all S. aureus strains[1].
Delafloxacin (2.5, 10, 40, and 160 mg/kg; subcutaneous injection, 24 h) has moderate terminal elimination half-life (t1/2=0.68 h, 0.79 h, 0.69 h and 1.0 h for 2.5 mg/kg, 10 mg/kg, 40 mg/kg, and 160 mg/kg, respectively)[1].

Animal Model: Mice with a neutropenic murine lung infection model (four S. aureus , four S. pneumoniae , and four K. pneumoniae strains)[1]
Dosage: The total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection
Administration: Delafloxacin (range, 0.03 to 160 mg/kg) are administered every 6 h (q6h) to infected mice by the subcutaneous route.
Result: Inhibited S. aureus strains ATCC 29213, ATCC 33591, MW2, R2527 with MICs of 0.008, 0.008, 0.004, and 0.004 mg/L, respectively.
Inhibited S. pneumoniae strains ATCC 10813, ATCC 49619, 145, and 1329 with MICs of 0.03, 0.125, 0.016, and 0.016 mg/L, respectively.
Inhibited K. pneumonia strains ATCC 43816, 4105, 4110, and 81-1260A with MICs of 0.06, 1, 0.5, and 0.06 mg/L, respectively.
Animal Model: Neutropenic mice[1]
Dosage: 2.5, 10, 40, and 160 mg/kg; 24 h; subcutaneous route
Administration: Single-dose plasma pharmacokinetics of Delafloxacin are performed in neutropenic mice. Animals are administered single subcutaneous doses (0.2 mL/dose) of Delafloxacin at dose levels of 2.5, 10, 40, and 160 mg/kg. Groups of three mice are sampled at each time point (seven time points, consisting of 1, 2, 4, 6, 8, 12, and 24 h) and dose level.
Result: The maximum drug concentrations (Cmax) concentrations ranged from 2 to 71 mg/L. AUC0-∞ values ranged from 2.8 to 152 mg•h/L and were linear across the 2.5- to 160-mg dosing range. The elimination half-life (t1/2) ranged from 0.7 to 1 h.
Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 6.4 mg/mL (10.06 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5724 mL 7.8620 mL 15.7240 mL
5 mM 0.3145 mL 1.5724 mL 3.1448 mL
10 mM 0.1572 mL 0.7862 mL 1.5724 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

635.97

Formula

C₂₅H₂₉ClF₃N₅O₉

CAS No.

352458-37-8

SMILES

O=C(C1=CN(C2=NC(N)=C(F)C=C2F)C3=C(C=C(F)C(N4CC(O)C4)=C3Cl)C1=O)O.O[[email protected]]([[email protected]]([[email protected]@H]([[email protected]@H](CO)O)O)O)CNC

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Delafloxacin meglumine
Cat. No.:
HY-14814A
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Delafloxacin meglumine

Cat. No.: HY-14814A