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NPTII Antibody (YA5303)

(Synonyms: neomycin phosphotransferase II)
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NPTII Antibody (YA5303) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NPTII.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Application:

    WB

  • Reactivity :

    Transgenic

  • Formulation:

    Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Conjugation:
    Non-conjugated
  • NPTII Antibody (YA5303) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:1000

Product Details

Description

NPTII Antibody (YA5303) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NPTII.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Transgenic
  • Observed Molecular Weight
    Observed band size: 29 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Sensitivity

Transfected

Purification

affinity chromatography.

Conjugation

Non-conjugated

Modification

Unmodified

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    NPTII is a Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization. Required to maintain normal cerebrospinal fluid phosphate levels. Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs[1][2][3][4].

  • Subcellular Localization

    Cell membrane; Multi-pass membrane protein; Apical cell membrane; Multi-pass membrane protein

  • Expression


    Tissue_specificity:Brain. In the brain, expressed in the choroid plexus, ependyma and arteriolar smooth muscle cells (at protein level) (PubMed:26822507) . Widely expressed including intestine, kidney, heart, liver, testis and skin. Expressed throughout the vertcal crypt-axial axis of intestinal epithelium (PubMed:11003594)

  • Subunit

    Homodimer

  • SwissProt ID

    Q80UP8

  • Gene ID
    20516 [NCBI]
  • Synonyms

    neomycin phosphotransferase II

NPTII Antibody (YA5303) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • NPTII Antibody (YA5303) Product Image