Search Result

Results for "

Alpha+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (2) Adenosine Receptor (1) Akt (6) AMPK (3) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (9) Apoptosis (53) Arp2/3 Complex (1) Arrestin (1) Autophagy (9) Bacterial (7) Bcl-2 Family (2) Calcium Channel (7) CaMK (1) Cannabinoid Receptor (1) Casein Kinase (15) Caspase (9) CD47 (1) CDK (5) CHIKV (1) Choline Kinase (4) CMV (1) COX (1) DAGL (3) DGK (14) DNA/RNA Synthesis (3) Drug Intermediate (2) Drug Metabolite (1) E1/E2/E3 Enzyme (1) EGFR (1) Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (1) ERK (3) Estrogen Receptor/ERR (10) FASTK (1) Fungal (1) Glucocorticoid Receptor (2) GSK-3 (3) HCV (1) HIF/HIF Prolyl-Hydroxylase (55) HIV (1) HSP (4) Hsp-targeting Chimeras (1) HSV (1) IFNAR (2) IKK (3) Interleukin Related (9) IRE1 (17) Isotope-Labeled Compounds (6) Leukotriene Receptor (1) LXR (2) MAGL (1) MAPKAPK2 (MK2) (1) MDM-2/p53 (12) MEK (1) Mitochondrial Metabolism (1) MMP (3) MOFs (1) Molecular Glues (1) Monoamine Oxidase (1) mTOR (2) NF-κB (5) NO Synthase (2) p38 MAPK (25) PAK (2) PASK/STK37 (1) PDGFR (2) PERK (2) PGC-1α (3) PGE synthase (1) Phosphatase (2) Phosphodiesterase (PDE) (1) Phospholipase (9) PI3K (47) PI4K (5) PI4P5K (1) Potassium Channel (8) PPAR (2) Prostaglandin Receptor (1) PROTACs (2) Raf (1) RANKL/RANK (1) RAR/RXR (1) Ras (1) Reactive Oxygen Species (ROS) (5) Reference Standards (17) REV-ERB (1) Ser/Thr Protease (1) TGF-beta/Smad (1) TGF-β Receptor (2) TNF Receptor (36) Topoisomerase (9) VEGFR (2) Wee1 (1) Wnt (2)
By Research Areas:	Cancer (189) Cardiovascular Disease (18) Endocrinology (2) Infection (21) Inflammation/Immunology (81) Metabolic Disease (24) Neurological Disease (19)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Aptamers (1)

273

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10231

PX-478 Maximum Cited Publications 95 Publications Verification	HIF/HIF Prolyl-Hydroxylase Autophagy	Cancer
PX-478 is an orally active *HIF-1α* inhibitor with potent antitumor activities. PX-478 can cross the blood-brain barrier .

HY-125840

Belzutifan 10+ Cited Publications PT2977; MK-6482	HIF/HIF Prolyl-Hydroxylase	Cancer
Belzutifan (PT2977) is an orally active and selective *HIF-2α* inhibitor with an IC₅₀ of 9 nM. Belzutifan, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. Belzutifan is a potential treatment for clear cell renal cell carcinoma (ccRCC) .

HY-12867

PT-2385 50+ Cited Publications	HIF/HIF Prolyl-Hydroxylase	Cancer
PT-2385 is a selective *HIF-2α* inhibitor with a K_i of less than 50 nM .

HY-156681

Tersolisib 1 Publications Verification STX-478; STX-478-101; LY4064809	PI3K	Cancer
STX-478 (compound 80) is an oral CNS-penetrant allosteric mutant-selective PI3Kα inhibitor. STX-478 shows robust and durable tumor regression and can be used in cancer research .

HY-114368

Kira8 10+ Cited Publications AMG-18	IRE1	Inflammation/Immunology
Kira8 (AMG-18) is a mono-selective *IRE1α* inhibitor that allosterically attenuates IRE1α RNase activity with an IC₅₀ of 5.9 nM .

HY-19710

MKC3946 5+ Cited Publications	IRE1	Cancer
MKC3946 is a potent *IRE1α* inhibitor, used for cancer research.

HY-15845

STF-083010 50+ Cited Publications	IRE1	Cancer
STF-083010 is a specific *IRE1α* inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.

HY-16937

ISA-2011B 15+ Cited Publications	PI4P5K	Cancer
ISA-2011B is a *PIP5K1α* inhibitor with promising anticancer effects .

HY-10801

CAY10650 5+ Cited Publications	Phospholipase	Inflammation/Immunology
CAY10650 is a highly potent cytosolic phospholipase A2α *(cPLA2α)* inhibitor with an IC₅₀ value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion .

HY-108431

MN58b 1 Publications Verification	Apoptosis	Cancer
MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity .

HY-111376

Pyrrophenone 4 Publications Verification	Phospholipase	Cardiovascular Disease Inflammation/Immunology
Pyrrophenone is a potent and specific cytosolic phospholipase A₂α (cPLA₂α) inhibitor with an IC₅₀ value of 4.2 nM .

HY-16596

CNX-1351	PI3K	Cancer
CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor with IC₅₀ of 6.8 nM.

HY-129571

BioE-1115	PASK/STK37 Ser/Thr Protease Casein Kinase	Metabolic Disease
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC₅₀ of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC₅₀ of ~10 μM .

HY-12285

Serabelisib MLN1117; INK1117; TAK-117	PI3K	Cancer
Serabelisib (MLN1117) is a selective *p110α* inhibitor with an IC₅₀ of 15 nM.

HY-13261

A66 3 Publications Verification	PI3K	Cancer
A66 is a highly specific and selective *p110α* inhibitor with an IC₅₀ of 32 nM.

HY-100735

C 87 2 Publications Verification	TNF Receptor	Inflammation/Immunology
C 87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC₅₀ of 8.73 μM.

HY-14975

R1487 Hydrochloride 1 Publications Verification	p38 MAPK Autophagy	Cancer
R1487 Hydrochloride is a highly potent and selective *p38α* inhibitor, with K_d values of 0.2 nM and 29 nM for p38α and p38β, respectively .

HY-W067427

BAY32-5915 1 Publications Verification	IKK	Cancer
BAY32-5915 is a potent IKKα inhibitor with an IC₅₀ value of 60 nM. BAY32-5915 has not affect Doxorubicin (HY-15142A)-induced NF-κB activation .

HY-101272

GDC-0326 1 Publications Verification	PI3K	Cancer
GDC-0326 is a potent and selective PI3Kα inhibitor with a K_i of 0.2 nM.

HY-115746

Dimethyl-bisphenol A DMBPA	HIF/HIF Prolyl-Hydroxylase	Cancer
Dimethyl-bisphenol A (DMBPA) is a potent *HIF-1α* inhibitor. Dimethyl-bisphenol A can decrease Vegfa mRNA expression .

HY-119019

ASB14780 1 Publications Verification	Phosphatase	Inflammation/Immunology
ASB14780 is a 4-phenoxy derivative, the cytosolic Phospholipase A₂α (cPLA₂α) inhibitor, with an IC₅₀ value of 20 nM .

HY-12825

BHPI	Estrogen Receptor/ERR Phospholipase	Cancer
BHPI is a nuclear receptor ERα inhibitor. BHPI activates PLCγ and UPR. BHPI has antitumor activity against breast, endometrial, and ovarian cancers .

HY-121944

Ricinine	Casein Kinase Wnt	Others
Ricinine exhibits hepatoprotection in CCl4-induced liver damage. Ricinine is also a *CK1α* inhibitor, and may activate Wnt pathway .

HY-112275

TNF-α-IN-1 3 Publications Verification	TNF Receptor	Infection Cardiovascular Disease Inflammation/Immunology Cancer
TNF-α-IN-1 (Compound I-7) is a *TNF-α* inhibitor. TNF-α-IN-1 can be studied in research for cancers, heart disease, autoimmune disease and infections .

HY-13864

PF-4989216 1 Publications Verification	PI3K Apoptosis	Cancer
PF-4989216 is a potent and selective PI3Kα inhibitor with a K_i of 0.6 nM.

HY-147078

EJMC-1	TNF Receptor	Inflammation/Immunology
EJMC-1 is a moderately potent *TNF-α* inhibitor with an IC₅₀ value of 42 μM .

HY-106253

Efipladib	Phospholipase	Inflammation/Immunology
Efipladib is a potent, selective and orally active *cPLA₂α* inhibitor with an IC₅₀ of 0.04 μM and a K_d of 0.067 μM .

HY-B1550

Benzoin DL-Benzoin; Desyl alcohol; (±)-2-Hydroxy-2-phenylacetophenone	PI3K	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Benzoin (DL-Benzoin) is a PI3Kα inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116) .

HY-19949

HIF-2α-IN-1 1 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
HIF-2α-IN-1 (compound 9b) is a *HIF-2α* inhibitor (IC₅₀=1.7 μM, SPA/scintillation proximity assay) .

HY-N4121

Isocurcumenol 1 Publications Verification	Estrogen Receptor/ERR Apoptosis	Cancer
Isocurcumenol, an *estrogen receptor alpha* (ERα)** inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC₅₀ values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively .

HY-16187

EL-102	HIF/HIF Prolyl-Hydroxylase Apoptosis	Cancer
EL-102 is a hypoxia-induced factor 1 *(Hif1α)* inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer .

HY-N8251

Cyclocurcumin	p38 MAPK	Cardiovascular Disease Inflammation/Immunology
Cyclocurcumin is a potent *p38α* inhibitor. Cyclocurcumin shows antirheumatic, antivasoconstrictive and antioxidant activities .

HY-131335

*p38α inhibitor* 2**	p38 MAPK	Inflammation/Immunology
p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC₅₀ of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC₅₀=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets .

HY-11105

Pilaralisib analogue 1 Publications Verification XL147 analogue	PI3K Apoptosis	Cancer
Pilaralisib analogue (XL147 analogue) is a representative and selective PI3Kα inhibitor extracted from patent WO2012006552A1, Compound 147 in Table 1.

HY-170331

IFNα-IN-1	IFNAR	Inflammation/Immunology
IFNα-IN-1 (AJ2-18) is a IFNα inhibitor that inhibits IFN-α production. IFNα-IN-1 can be used for research of inflammation .

HY-137144

Fulvestrant-3-boronic acid ZB716	Estrogen Receptor/ERR	Cancer
Fulvestrant-3-boronic acid is an orally active ERα inhibitor, which binds to ERα competitively (IC₅₀ = 4.1 nM) and effectively degrades ERα in breast cancer cells .

HY-W009338

H-Val-Tyr-OH 1 Publications Verification Val-Tyr	IKK NF-κB	Inflammation/Immunology Cancer
H-Val-Tyr-OH (Val-Tyr) is a dipeptide formed by the connection of valine and tyrosine via a peptide bond. H-Val-Tyr-OH is a potential IKKα inhibitor and can be used in the research of cancer and inflammatory diseases .

HY-116301

CAY10502	Phospholipase	Inflammation/Immunology
CAY10502 is a potent, calcium-dependent cytosolic phospholipase A2 α (cPLA₂α) inhibitor with an IC₅₀ of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases .

HY-114423

*p38α inhibitor* 1**	p38 MAPK Autophagy	Inflammation/Immunology
p38α inhibitor 1 is a *p38α* inhibitor extracted from patent WO 2008076265 A1.

HY-125840R

Belzutifan (Standard) PT2977 (Standard); MK-6482 (Standard)	HIF/HIF Prolyl-Hydroxylase Reference Standards	Cancer
Belzutifan (Standard) is the analytical standard of Belzutifan. This product is intended for research and analytical applications. Belzutifan (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. Belzutifan, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. Belzutifan is a potential treatment for clear cell renal cell carcinoma (ccRCC) .

HY-133807A

(Rac)-Benpyrine	TNF Receptor	Inflammation/Immunology
(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active *TNF-α* inhibitor. (Rac)-Benpyrine has the potential for *TNF-α* mediated inflammatory and autoimmune disease research .

HY-108697A

(Rac)-PT2399	HIF/HIF Prolyl-Hydroxylase	Cancer
(Rac)-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a *(HIF-2α)* inhibitor with an IC₅₀ of 0.01 μM .

HY-159799

*p38α inhibitor* 5**	p38 MAPK	Cancer
p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand targeting p38 and can be used to synthesize NR-11c (HY-159798) .

HY-114368A

Kira8 Hydrochloride 10+ Cited Publications AMG-18 Hydrochloride	IRE1	Inflammation/Immunology
Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selective *IRE1α* inhibitor that allosterically attenuates IRE1α RNase activity with an IC₅₀ of 5.9 nM .

HY-172608

TNF-α-IN-24	TNF Receptor	Inflammation/Immunology
TNF-α-IN-24 (Example 15) is a *TNF-α* inhibitor with an IC₅₀ of 4.1 nM. TNF-α-IN-24 can be used in study of inflammatory and autoimmune disorders such as rheumatoid arthritis and Crohn’s disease .

HY-153330

TNF-α-IN-10	Interleukin Related TNF Receptor	Inflammation/Immunology
TNF-α-IN-10 (compound 8a) is a IL-6 and *TNF-α* inhibitor. TNF-α-IN-10 shows anti-inflammatory activity .

HY-W150426

Naphthol AS-BS	CMV DNA/RNA Synthesis	Infection
Naphthol AS-BS (Compound 1) is a human cytomegalovirus (HCMV) DNA polymerase alpha inhibitor with an IC₅₀ of 12 μM. Naphthol AS-BS can be used for the research of infection .

HY-U00179

CDC801	Phosphodiesterase (PDE) TNF Receptor	Cancer
CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC₅₀ of 1.1 μM and 2.5 μM, respectively.

HY-178287

TNF-α-IN-27	TNF Receptor	Inflammation/Immunology
TNF-α-IN-27 (Compound 1) is a *TNF-α* inhibitor with inhibition rate of 64% at 10 μM. TNF-α-IN-27 can be used for the researches of inflammation and immunology, such as asthma .

HY-162599

Spirohypertone B	TNF Receptor	Infection Cancer
Spirohypertone B is a potent Tumor necrosis factor-α (TNF-α) inhibitor. Spirohypertone B protects L929 cells from death induced by co-incubation with TNF-α and Actinomycin D (HY-17559) .

Cat. No.	Product Name	Target	Research Area

HY-P10426

cyclo(CLLFVY)	HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC₅₀ of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99153

Farletuzumab MORAb-003	Antibiotic	Cancer
Farletuzumab (MORAb-003) is a potent *folate receptor-alpha* (FRα)** inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer .

HY-P990033

Anzurstobart CC-95251; BMS-986351	CD47	Cancer
Anzurstobart is a CD47/SIRPα inhibitor with human SIRPα K_d of 0.0541 nM and human SIRPα IC₅₀ of 100 nM. Anzurstobart binds SIRPα at a CD47-overlapping site, blocks CD47-SIRPα interactions, inhibits CD47-SIRPα axis signaling, and binds across 6 prevalent human SIRPα haplotypes. Anzurstobart binds SIRPγ and inhibits CD47-SIRPγ interactions. Anzurstobart can be used for the research of non-Hodgkin's lymphoma, colorectal cancer, squamous cell carcinoma of the head and neck, diffuse large B-cell lymphoma, and advanced solid and hematologic malignancies .

HY-P99782

Opinercept	TNF Receptor	Inflammation/Immunology
Opinercept is a recombinant fusion protein comprising an TNFRSF1B fused to a human IgG1 Fc . Opinercept is a tumor necrosis factor-alpha *(TNF-alpha)* inhibitor. Opinercept can be used for the research of rheumatoid arthritis (RA) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0835

(20S)-Protopanaxatriol 1 Publications Verification 20(S)-APPT; g-PPT	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-N0853

Alisol A 5 Publications Verification	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Classification of Application Fields Terpenoids Other Diseases Alismataceae Plants Disease Research Fields Source Classification	AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related
Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .

HY-121944

Ricinine	Alkaloids Classification of Application Fields Ricinus communis L. Other Diseases Pyridine Alkaloids Euphorbiaceae Plants Disease Research Fields Source Classification	Casein Kinase Wnt
Ricinine exhibits hepatoprotection in CCl4-induced liver damage. Ricinine is also a *CK1α* inhibitor, and may activate Wnt pathway .

HY-B1550

Benzoin DL-Benzoin; Desyl alcohol; (±)-2-Hydroxy-2-phenylacetophenone	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	PI3K
Benzoin (DL-Benzoin) is a PI3Kα inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116) .

HY-N4121

Isocurcumenol 1 Publications Verification	other families Classification of Application Fields Terpenoids Sesquiterpenes Plants Disease Research Fields Source Classification Cancer	Estrogen Receptor/ERR Apoptosis
Isocurcumenol, an *estrogen receptor alpha* (ERα)** inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC₅₀ values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively .

HY-N12717

Casuarinin	Terminalia arjuna (Roxb. ex DC.) Wight & Arn. Structural Classification Combretaceae Phenols Polyphenols Plants Source Classification	PAK FASTK HSP p38 MAPK NF-κB NO Synthase COX HSV Caspase TNF Receptor Fungal Apoptosis
Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of *TNF‑α*, inhibits the growth of *Candida albicans, and inhibits* HSV‑2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections .

HY-N8251

Cyclocurcumin	Phenols Polyphenols Plants Curcuma longa Source Classification Zingiberaceae	p38 MAPK
Cyclocurcumin is a potent *p38α* inhibitor. Cyclocurcumin shows antirheumatic, antivasoconstrictive and antioxidant activities .

HY-W009338

H-Val-Tyr-OH 1 Publications Verification Val-Tyr	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	IKK NF-κB
H-Val-Tyr-OH (Val-Tyr) is a dipeptide formed by the connection of valine and tyrosine via a peptide bond. H-Val-Tyr-OH is a potential IKKα inhibitor and can be used in the research of cancer and inflammatory diseases .

HY-N13009

MO-2097	Phenols Polyphenols Morus alba L. Plants Moraceae Source Classification	Raf HIF/HIF Prolyl-Hydroxylase ERK MEK Reactive Oxygen Species (ROS) Apoptosis Caspase
MO-2097 is a *RAF-1/HIF-1α* inhibitor. MO-2097 induces RAF-1 destabilization, leading to a reduction in EMT-associated transcription factors and mesenchymal markers. MO-2097 inhibits HIF-1a protein expression mediated by hnRNPA2B1 under hypoxic and mimetic hypoxia. MO-2097 induces mitochondrial ROS, which leads to apoptosis in cells. MO-2097 effectively suppresses colorectal cancer metastasis by inhibiting the RAF/MEK/ERK signaling pathway. MO-2097 attenuates tumor growth in a xenograft HCT116 cell mouse model. MO-2097 can be used for the study of colorectal cancer .

HY-100513

(±)-Dehydroaltenusin	Structural Classification Microorganisms Antibiotics Source Classification	DNA/RNA Synthesis Apoptosis Antibiotic
(±)-Dehydroaltenusin, an antibiotic, is a selective eukaryotic DNA polymerase α (pol α) inhibitor with an IC₅₀ of 0.68 μM. (±)-Dehydroaltenusin can be isolated from fungus Alternaria tenuis. (±)-Dehydroaltenusin competitively inhibits the DNA template primer (K_i: 0.23 μM) and non-competitively suppresses the 2'-deoxyribonucleoside 5'-triphosphate substrate (K_i: 0.18 μM). (±)-Dehydroaltenusin induces the cancer cell S-phase cycle arrest and apoptosis. (±)-Dehydroaltenusin can be used for cancers like human adenocarcinoma research .

HY-162599

Spirohypertone B	Structural Classification Natural Products Apiaceae Hypericaceae Hypericum patulum Thunb. Plants Heracleum sibiricum L. Source Classification	TNF Receptor
Spirohypertone B is a potent Tumor necrosis factor-α (TNF-α) inhibitor. Spirohypertone B protects L929 cells from death induced by co-incubation with TNF-α and Actinomycin D (HY-17559) .

HY-N7821

Aphidicolin 17-acetate Aphidicolin 17-monoacetate	Structural Classification Natural Products Microorganisms Source Classification	DNA/RNA Synthesis
Aphidicolin 17-acetate is a selective eukaryotic DNA polymerase α inhibitor. Aphidicolin 17-acetate does not inhibit DNA polymerase β and γ. Aphidicolin 17-acetate markedly inhibits the in vivo DNA synthesis of sea urchin embryos and HeLa cells but not RNA and protein syntheses .

HY-B1550R

Benzoin (Standard) DL-Benzoin (Standard); Desyl alcohol (Standard); (±)-2-Hydroxy-2-phenylacetophenone (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards PI3K
Benzoin (Standard) (DL-Benzoin (Standard)) is the analytical standard of Benzoin (HY-B1550). This product is intended for research and analytical applications. Benzoin (DL-Benzoin), a natural balsamic resin, is a PI3Kα inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116). Benzoin can be used as a food additive.

HY-N0835R

(20S)-Protopanaxatriol (Standard) 20(S)-APPT (Standard); g-PPT (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Plants Araliaceae Source Classification	Reference Standards Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol (Standard) is the analytical standard of (20S)-Protopanaxatriol. This product is intended for research and analytical applications. (20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-N10330

7-Hydroxyneolamellarin A	Animals Phenols Source Classification	HIF/HIF Prolyl-Hydroxylase VEGFR
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer .

HY-N0853R

Alisol A (Standard)	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Terpenoids Alismataceae Plants Source Classification	Reference Standards AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related
Alisol A (Standard) is the analytical standard of Alisol A (HY-N0853). This product is intended for research and analytical applications. Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .

HY-N19295

Echiguanine A	Structural Classification Natural Products Microorganisms Source Classification	PI4K
Echiguanine A is a phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC₅₀ of 0.04 μg/mL. Echiguanine A inhibits phosphatidylinositol 4-kinase activity in cell membrane extracts. Echiguanine A is applicable for cancer research .

HY-N19756

Cochinchinone P	Structural Classification Flavonoids Cratoxylum cochinchinense (Lour.) Blume Hypericaceae Plants Other Flavonoids Source Classification	RAR/RXR
Cochinchinone P is a retinoid X receptor-α (RXRα) inhibitor that inhibits 9-cis-retinoic acid (HY-15128)-induced transcriptional activity of RXRα in vitro. Cochinchinone P can be used in cancer research .

Cat. No.	Product Name	Chemical Structure

HY-17412AS

Minocycline-d6

Minocycline-d₆ is deuterium labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412S1

Minocycline-d6 sulfate

Minocycline-d₆ sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412S

Minocycline-d6 hydrochloride

Minocycline-d₆ hydrochloride is deuterated labeled Minocycline hydrochloride (HY-17412). Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-B1550S

Benzoin-d10
Benzoin-d₁₀ (DL-Benzoin-d₁₀) is the deuterium labeled Benzoin (HY-B1550). Benzoin (DL-Benzoin), a natural balsamic resin, is a PI3Kα inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116). Benzoin can be used as a food additive .

HY-101491S

SR-18292-d9
SR-18292-d₉ is the deuterium labeled SR-18292 (HY-101491). SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes .

HY-W654013

Minocycline-d7

Minocycline-d₇ is deuterium labeled Minocycline. Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

Cat. No.	Product Name		Classification

HY-159799

*p38α inhibitor* 5**		Alkynes
p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand targeting p38 and can be used to synthesize NR-11c (HY-159798) .

HY-148908

TNF-α-IN-8		Azide
TNF-α-IN-8 (compound I-42) is a *TNF-α* inhibitor. TNF-α-IN-8 is an isoindole-imide compound. TNF-α-IN-8 can be used for the research of cancer, heart disease, osteoporosis, inflammatory, allergic and autoimmune diseases . TNF-α-IN-8 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-177406

VR11 aptamer		Aptamers
VR11 aptamer is a DNA-based *TNF-α* inhibitor with a K_D of 7.0 nM. VR11 aptamer prevents TNFα-induced apoptosis and NO production. VR11 aptamer has non-immunogenicity and does not raise immune responses when injected intraperitoneally into C57BL/6 mice model. VR11 aptamer can be used for inflammatory diseases research .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks