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Cat. No.: HY-N19295

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Echiguanine A

Echiguanine A is a phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC₅₀ of 0.04 μg/mL. Echiguanine A inhibits phosphatidylinositol 4-kinase activity in cell membrane extracts. Echiguanine A is applicable for cancer research.

For research use only. We do not sell to patients.

CAS No.: 137319-25-6
Formula: C₁₀H₁₃N₇O₂
Molecular Weight:263.26

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Please store the product under the recommended conditions in the Certificate of Analysis.

Echiguanine A Chemical Structure

CAS No.: 137319-25-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
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Biological Activity

Description

All PI4K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	0.03 μg/mL Compound: 1 (echiguanine A)	Inhibition of Phosphatidylinositol 4-kinase of human epidermoid carcinoma A431 cells Inhibition of Phosphatidylinositol 4-kinase of human epidermoid carcinoma A431 cells	10.1016/S0960-894X(97)00122-4

In Vitro

Echiguanine A (Compound 1) (20 min) potently inhibits phosphatidylinositol-4-kinase derived from A431 cell membranes, with an IC₅₀ value of 0.04 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 137319-25-6
Molecular Weight 263.26
Formula C₁₀H₁₃N₇O₂
SMILES

O=C1N=C(NC2=C1C(C(NCCC(N)=N)=O)=CN2)N
Structure Classification
- Others
Initial Source
- Microorganisms
Streptomyces sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nishioka H, et al. Isolation and structure determination of novel phosphatidylinositol kinase inhibitors, echiguanines A and B, from Streptomyces sp. J Nat Prod. 1991;54(5):1321-1325. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Echiguanine A

All PI4K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Echiguanine A Related Classifications

HY-N19295 Related Classifications