2. PI3K/Akt/mTOR
  3. PI3K
  4. PITCOIN4

PITCOIN4 is a highly selective Class II Alpha PI3K-C2α inhibitor. PITCOIN4 shows nanomolar inhibition of PI3K-C2α and >100-fold selectivity in a general kinase panel.

For research use only. We do not sell to patients.

PITCOIN4 Chemical Structure

PITCOIN4 Chemical Structure

Size Price Stock Quantity
1 mg USD 230 In-stock
5 mg USD 570 In-stock
10 mg USD 910 In-stock
25 mg USD 1680 In-stock
50 mg USD 2260 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PITCOIN4 is a highly selective Class II Alpha PI3K-C2α inhibitor. PITCOIN4 shows nanomolar inhibition of PI3K-C2α and >100-fold selectivity in a general kinase panel[1].

Molecular Weight

599.73

Formula

C30H29N7O3S2
Appearance

Solid

Color

White to light yellow

SMILES

CC(C)(NC(CC1=CSC(NC(CSC(N2CCC3=CC=CC=C3)=NC4=C(C2=O)N=CC=N4)=O)=N1)=O)C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (208.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6674 mL 8.3371 mL 16.6742 mL
5 mM 0.3335 mL 1.6674 mL 3.3348 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.97%

COA (250 KB) HNMR (295 KB) LCMS (108 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6674 mL 8.3371 mL 16.6742 mL 41.6854 mL
5 mM 0.3335 mL 1.6674 mL 3.3348 mL 8.3371 mL
10 mM 0.1667 mL 0.8337 mL 1.6674 mL 4.1685 mL
15 mM 0.1112 mL 0.5558 mL 1.1116 mL 2.7790 mL
20 mM 0.0834 mL 0.4169 mL 0.8337 mL 2.0843 mL
25 mM 0.0667 mL 0.3335 mL 0.6670 mL 1.6674 mL
30 mM 0.0556 mL 0.2779 mL 0.5558 mL 1.3895 mL
40 mM 0.0417 mL 0.2084 mL 0.4169 mL 1.0421 mL
50 mM 0.0333 mL 0.1667 mL 0.3335 mL 0.8337 mL
60 mM 0.0278 mL 0.1390 mL 0.2779 mL 0.6948 mL
80 mM 0.0208 mL 0.1042 mL 0.2084 mL 0.5211 mL
100 mM 0.0167 mL 0.0834 mL 0.1667 mL 0.4169 mL
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PITCOIN4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PITCOIN4PITCOIN 4PITCOIN-4PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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