KR-27370

Cat. No.: HY-161357: Data Sheet Handling Instructions
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KR-27370 (compound 7f) is an antiviral agent and selective PI4KIIIβ/PI4KIIIα inhibitor (IC₅₀: 3.1 nM/15.8 nM), against hRV, Ke Saatchivirus and other enteroviruses have inhibitory activity.

For research use only. We do not sell to patients.

KR-27370 Chemical Structure

CAS No. : 3097359-18-4

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PI4KIIIβ PI4KIIIα PI4K PI4KII

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

PI4KIIIβ

3.1 nM (IC₅₀, ^[1])

PI4KIIIα

15.8 nM (IC₅₀, ^[1])

Cellular Effect

Cell Line	Type	Value	Description	References
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 100 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 100 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 13 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 13 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 1B measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 1B measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 2 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 2 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 23 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 23 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 27 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 27 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 31 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 31 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 33 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 33 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 37 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 37 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 42 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 42 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 45 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 45 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 51 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 51 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 53 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 53 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 63 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 63 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 68 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 68 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 71 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 71 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 73 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 73 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 86 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 86 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 91 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 91 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 93 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 93 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 98 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 98 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected enterovirus A71 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected enterovirus A71 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected enterovirus D68 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected enterovirus D68 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected with 1 MOI human rhinovirus 14 pretreated with compound for 1 hr followed by viral infection measured by MTT assay Cytotoxicity against human H1-HeLa cells infected with 1 MOI human rhinovirus 14 pretreated with compound for 1 hr followed by viral infection measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B1 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B1 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B2 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B2 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B3 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B3 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B4 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B4 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B5 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B5 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	> 50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B6 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B6 measured by MTT assay	[PMID: 38389877]
LLC-MK2	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against rhesus macaque LLC-MK2 cells infected with HCoV-NL63 by MTT assay Cytotoxicity against rhesus macaque LLC-MK2 cells infected with HCoV-NL63 by MTT assay	[PMID: 38389877]
MRC5	CC₅₀	5.8 μM Compound: 7f; KR-27370	Cytotoxicity against human MRC5 cells infected with HCoV-229E by MTT assay Cytotoxicity against human MRC5 cells infected with HCoV-229E by MTT assay	[PMID: 38389877]
MRC5	CC₅₀	5.8 μM Compound: 7f; KR-27370	Cytotoxicity against human MRC5 cells infected with HCoV-OC43 by MTT assay Cytotoxicity against human MRC5 cells infected with HCoV-OC43 by MTT assay	[PMID: 38389877]
Vero	CC₅₀	> 100 μM Compound: 7f; KR-27370	Cytotoxicity against green monkey vero cells infected with SARS-CoV2 by MTT assay Cytotoxicity against green monkey vero cells infected with SARS-CoV2 by MTT assay	[PMID: 38389877]

In Vitro

KR-27370 has low cytotoxicity (CC50: >100 μM, H1HeLa), and its EC50 against hRV B14, hRV A16, and hRV A21 are 22 nM, 32 nM, and 36 nM respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

553.65

Formula

C₂₇H₂₇N₃O₆S₂

CAS No.

3097359-18-4

SMILES

COC1=CC(OC)=CC(CC(NC2=NC(C)=C(C3=CC=C(OC)C(NS(C4=CC=CC=C4)(=O)=O)=C3)S2)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. G Vishakantegowda A, et al. Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents. RSC Med Chem. 2023 Dec 21;15(2):704-719. [Content Brief]

KR-27370 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KR-273703097359-18-4KR27370KR 27370PI4KPhosphatidylinositol 4 kinasesPI4 kinaseshRVcoxsackievirusenterovirusInhibitorinhibitorinhibit

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