Cat. No.: HY-161357

KR-27370

KR-27370 (compound 7f) is an antiviral agent and selective PI4KIIIβ/PI4KIIIα inhibitor (IC₅₀: 3.1 nM/15.8 nM), against hRV, Ke Saatchivirus and other enteroviruses have inhibitory activity.

For research use only. We do not sell to patients.

CAS No.: 3097359-18-4
Formula: C₂₇H₂₇N₃O₆S₂
Molecular Weight:553.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

KR-27370 Chemical Structure

CAS No.: 3097359-18-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

PI4KIIIβ

3.1 nM (IC₅₀, ^[1])

PI4KIIIα

15.8 nM (IC₅₀, ^[1])

All PI4K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected enterovirus A71 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected enterovirus A71 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected enterovirus D68 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected enterovirus D68 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 100 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 100 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 13 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 13 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 1B measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 1B measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 2 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 2 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 23 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 23 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 27 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 27 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 31 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 31 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 33 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 33 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 37 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 37 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 42 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 42 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 45 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 45 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 51 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 51 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 53 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 53 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 63 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 63 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 68 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 68 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 71 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 71 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 73 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 73 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 86 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 86 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 91 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 91 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 93 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 93 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 98 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human rhinovirus 98 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected with 1 MOI human rhinovirus 14 pretreated with compound for 1 hr followed by viral infection measured by MTT assay Cytotoxicity against human H1-HeLa cells infected with 1 MOI human rhinovirus 14 pretreated with compound for 1 hr followed by viral infection measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B1 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B1 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B2 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B2 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B3 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Coxsackievirus B3 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B4 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B4 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B5 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B5 measured by MTT assay	[PMID: 38389877]
H1-HeLa	CC₅₀	>50 μM Compound: 7f; KR-27370	Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B6 measured by MTT assay Cytotoxicity against human H1-HeLa cells infected Human coxsackievirus B6 measured by MTT assay	[PMID: 38389877]
LLC-MK2	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against rhesus macaque LLC-MK2 cells infected with HCoV-NL63 by MTT assay Cytotoxicity against rhesus macaque LLC-MK2 cells infected with HCoV-NL63 by MTT assay	[PMID: 38389877]
MRC5	CC₅₀	5.8 μM Compound: 7f; KR-27370	Cytotoxicity against human MRC5 cells infected with HCoV-229E by MTT assay Cytotoxicity against human MRC5 cells infected with HCoV-229E by MTT assay	[PMID: 38389877]
MRC5	CC₅₀	5.8 μM Compound: 7f; KR-27370	Cytotoxicity against human MRC5 cells infected with HCoV-OC43 by MTT assay Cytotoxicity against human MRC5 cells infected with HCoV-OC43 by MTT assay	[PMID: 38389877]
Vero	CC₅₀	>100 μM Compound: 7f; KR-27370	Cytotoxicity against green monkey vero cells infected with SARS-CoV2 by MTT assay Cytotoxicity against green monkey vero cells infected with SARS-CoV2 by MTT assay	[PMID: 38389877]

In Vitro

KR-27370 has low cytotoxicity (CC50: >100 μM, H1HeLa), and its EC50 against hRV B14, hRV A16, and hRV A21 are 22 nM, 32 nM, and 36 nM respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3097359-18-4
Molecular Weight 553.65
Formula C₂₇H₂₇N₃O₆S₂
SMILES

COC1=CC(OC)=CC(CC(NC2=NC(C)=C(C3=CC=C(OC)C(NS(C4=CC=CC=C4)(=O)=O)=C3)S2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. G Vishakantegowda A, et al. Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents. RSC Med Chem. 2023 Dec 21;15(2):704-719. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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KR-27370

All PI4K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KR-27370 Related Classifications

HY-161357 Related Classifications