2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. O-7460

O-7460 is a potent and selective DAGLα inhibitor, with an IC50 of 0.69 μM. O-7460 shows selectivity over onoacylglycerol lipase (MAGL), human CB1 and CB2 cannabinoid receptors. O-7460 can decrease HFD-caused an up-regulation of 2-AG levels.

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O-7460 Chemical Structure

O-7460 Chemical Structure

CAS No. : 1572051-31-0

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Description

O-7460 is a potent and selective DAGLα inhibitor, with an IC50 of 0.69 μM. O-7460 shows selectivity over onoacylglycerol lipase (MAGL), human CB1 and CB2 cannabinoid receptors. O-7460 can decrease HFD-caused an up-regulation of 2-AG levels[1].

IC50 & Target

IC50: 0.69 μM (DAGLα)[1]
In Vitro

O-7460 (10 μM; 20 min) decreases the Ionomycin (3 μM)-induced formation of 2-AG in N18TG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

O-7460 Related Antibodies
In Vivo

O-7460 (6-12 mg/kg; a single i.p.) induces a time- and dose-dependent decrease in high-fat diet (HFD) intake and counteracts the body weight increase of mice[1].
O-7460 (12 mg/kg; i.p.) decreases the HFD-caused an up-regulation of 2-AG levels in the hypothalamus and liver of mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old male C57BL/6N inbred mice were administrated high-fat diet (HFD) diet[1]
Dosage: 6, 12 mg/kg
Administration: A single i.p.
Result: Induced a time (30 min, 60 min and 14 h after O-7460 administration) and dose-dependent decrease in HFD intake.
The highest dose significantly counteracted the body weight increase.
Molecular Weight

478.62

Formula

C25H48FO5P
CAS No.
SMILES

CC(OCC(COP(F)(C)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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O-7460 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O-74601572051-31-0O7460O 7460Cannabinoid ReceptorDAGLα2-AGobesityInhibitorinhibitorinhibit

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