Topoisomerase II-IN-24
Topoisomerase II-IN-24 is a Topoisomerase IIα inhibitor with an IC50 of 41.67 μM. Topoisomerase II-IN-24 can inhibit cancer cells proliferation, induce G2/M phase arrest and induce apoptosis. Topoisomerase II-IN-24 can be used for the research of cancer, such as colon cancer.
For research use only. We do not sell to patients.
- CAS No.: 613254-63-0
- Formula: C27H23ClN4O2S2
- Molecular Weight:535.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
topoisomerase II alpha 41.67 μM (IC50) |
Caspase 3 |
In Vitro
Topoisomerase II-IN-24 (Compound 8) (10 μM) exhibits potent cytotoxicity against multiple cancer cell lines, especially NCI-H522 and UACC-62 with GI% of 97.7% and 98.95%, respectively[1].
Topoisomerase II-IN-24 has a GI50 of 2.61 μM in HT-29 colon cancer cells and an IC50 of 44.37 μM in FHC normal colon cells[1].
Topoisomerase II-IN-24 (0.1-100 μM) exhibits dose-dependent Topoisomerase IIα inhibitory activity with an IC50 of 41.67 μM[1].
Topoisomerase II-IN-24 (2.61 μM, 24 h) induces G2/M phase arrest in HT-29 cells[1].
Topoisomerase II-IN-24 (2.61 μM, 24 h) induces apoptosis and increases the caspase-3 level in HT-29 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-29 cells
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Concentration:2.61 μM
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Incubation Time:24 h
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Result:Increased G2/M phase proportion from 16.03% to 41.37%.
Decreased G0/G1 and S phases to 35.08% and 23.41%.
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Cell Line:HT-29 cells
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Concentration:2.61 μM
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Incubation Time:24 h
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Result:Increased the total apoptotic ratio of HT-29 cells by 19.1-fold.
Increased the caspase-3 level.
Chemical Information
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CAS No. 613254-63-0
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Molecular Weight 535.08
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Formula C27H23ClN4O2S2
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SMILES
O=C(N/N=C/C=C/C1=CC=CC=C1)CSC2=NC3=C(C4=C(S3)CCCC4)C(N2C5=CC=C(C=C5)Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topoisomerase II-IN-24 Related Classifications
HY-175853 Related Classifications
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