Naphthol AS-BS
Based on 1 Customer Validation
Naphthol AS-BS (Compound 1) is a human cytomegalovirus (HCMV) DNA polymerase alpha inhibitor with an IC50 of 12 μM. Naphthol AS-BS can be used for the research of infection.
For research use only. We do not sell to patients.
- Purity : 99.12%
- CAS No.: 135-65-9
- Formula: C17H12N2O4
- Molecular Weight:308.29
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Description
IC50 & Target
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DNA Polymerase |
Chemical Information
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CAS No. 135-65-9
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Appearance Solid
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Molecular Weight 308.29
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Formula C17H12N2O4
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Color Light yellow to yellow
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SMILES
OC1=C(C(NC2=CC([N+]([O-])=O)=CC=C2)=O)C=C3C=CC=CC3=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (324.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2437 mL | 16.2185 mL | 32.4370 mL | 81.0925 mL |
| 5 mM | 0.6487 mL | 3.2437 mL | 6.4874 mL | 16.2185 mL | |
| 10 mM | 0.3244 mL | 1.6218 mL | 3.2437 mL | 8.1092 mL | |
| 15 mM | 0.2162 mL | 1.0812 mL | 2.1625 mL | 5.4062 mL | |
| 20 mM | 0.1622 mL | 0.8109 mL | 1.6218 mL | 4.0546 mL | |
| 25 mM | 0.1297 mL | 0.6487 mL | 1.2975 mL | 3.2437 mL | |
| 30 mM | 0.1081 mL | 0.5406 mL | 1.0812 mL | 2.7031 mL | |
| 40 mM | 0.0811 mL | 0.4055 mL | 0.8109 mL | 2.0273 mL | |
| 50 mM | 0.0649 mL | 0.3244 mL | 0.6487 mL | 1.6218 mL | |
| 60 mM | 0.0541 mL | 0.2703 mL | 0.5406 mL | 1.3515 mL | |
| 80 mM | 0.0405 mL | 0.2027 mL | 0.4055 mL | 1.0137 mL | |
| 100 mM | 0.0324 mL | 0.1622 mL | 0.3244 mL | 0.8109 mL |
Naphthol AS-BS Related Classifications
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