1. MAPK/ERK Pathway
    Autophagy
  2. p38 MAPK
    Autophagy
  3. R1487 Hydrochloride

R1487 Hydrochloride 

Cat. No.: HY-14975 Purity: 98.94%
Handling Instructions

R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α.

For research use only. We do not sell to patients.

R1487 Hydrochloride Chemical Structure

R1487 Hydrochloride Chemical Structure

CAS No. : 449808-64-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 348 In-stock
Estimated Time of Arrival: December 31
50 mg USD 588 In-stock
Estimated Time of Arrival: December 31
100 mg USD 948 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α. target: p38α; R1487 (Hydrochloride) potently inhibits cytokine production in a variety of in vitro and in vivo models.[1] R1487 (Hydrochloride) inhibits production of TNFR by human monocytic cells (THP-1) and inhibits production of IL-1β in human whole blood (HWB) induced by LPS.[1]

Molecular Weight

424.83

Formula

C₁₉H₁₉ClF₂N₄O₃

CAS No.

449808-64-4

SMILES

O=C1C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC4CCOCC4)N=C3N1C.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (49.03 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3539 mL 11.7694 mL 23.5388 mL
5 mM 0.4708 mL 2.3539 mL 4.7078 mL
10 mM 0.2354 mL 1.1769 mL 2.3539 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.94%

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Product Name:
R1487 Hydrochloride
Cat. No.:
HY-14975
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