1. MAPK/ERK Pathway
    Autophagy
  2. p38 MAPK
    Autophagy
  3. R1487 Hydrochloride

R1487 Hydrochloride 

Cat. No.: HY-14975 Purity: 98.94%
Handling Instructions

R1487 Hydrochloride is a highly potent and selective p38α inhibitor, with Kd values of 0.2 nM and 29 nM for p38α and p38β, respectively.

For research use only. We do not sell to patients.

R1487 Hydrochloride Chemical Structure

R1487 Hydrochloride Chemical Structure

CAS No. : 449808-64-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 132 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 348 In-stock
Estimated Time of Arrival: December 31
50 mg USD 588 In-stock
Estimated Time of Arrival: December 31
100 mg USD 948 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

R1487 Hydrochloride is a highly potent and selective p38α inhibitor, with Kd values of 0.2 nM and 29 nM for p38α and p38β, respectively[1].

IC50 & Target

p38α

0.2 nM (Kd)

p38β

29 nM (Kd)

In Vitro

R1487 Hydrochloride exhibits IC50 values of 10 nM for p38α inhibition and 200 nM for the inhibition of TNFα induced production of IL-1β[1].
R1487 (Compounds 2a) inhibits production of TNFα by human monocytic cells (THP-1) and inhibits production of IL-1β in human whole blood (HWB) induced by LPS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

R1487 (Compounds 2a, orally) demonstrates significant dose-dependent inhibition of serum TNFα and IL-1β[1].
Oral bioavailability of 10 mg/kg R1487 (Compounds 2a) in monkey, rat, and dog was 51.6%, 29.3%, 10.3%, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

424.83

Formula

C₁₉H₁₉ClF₂N₄O₃

CAS No.
SMILES

O=C1C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC4CCOCC4)N=C3N1C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (49.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3539 mL 11.7694 mL 23.5388 mL
5 mM 0.4708 mL 2.3539 mL 4.7078 mL
10 mM 0.2354 mL 1.1769 mL 2.3539 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

R1487R 1487R-1487p38 MAPKAutophagyTNFαIL-1βTHP-1Inhibitorinhibitorinhibit

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Product Name:
R1487 Hydrochloride
Cat. No.:
HY-14975
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