1. MAPK/ERK Pathway
  2. p38 MAPK

R1487 Hydrochloride 

Cat. No.: HY-14975 Purity: 98.68%
Handling Instructions

R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α.

For research use only. We do not sell to patients.

R1487 Hydrochloride Chemical Structure

R1487 Hydrochloride Chemical Structure

CAS No. : 449808-64-4

Size Price Stock Quantity
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 348 In-stock
Estimated Time of Arrival: December 31
50 mg USD 588 In-stock
Estimated Time of Arrival: December 31
100 mg USD 948 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α. target: p38α; R1487 (Hydrochloride) potently inhibits cytokine production in a variety of in vitro and in vivo models.[1] R1487 (Hydrochloride) inhibits production of TNFR by human monocytic cells (THP-1) and inhibits production of IL-1β in human whole blood (HWB) induced by LPS.[1]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 28 mg/mL (65.91 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3539 mL 11.7694 mL 23.5388 mL
5 mM 0.4708 mL 2.3539 mL 4.7078 mL
10 mM 0.2354 mL 1.1769 mL 2.3539 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

424.83

Formula

C₁₉H₁₉ClF₂N₄O₃

CAS No.

449808-64-4

SMILES

O=C1C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC4CCOCC4)N=C3N1C.Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
R1487 Hydrochloride
Cat. No.:
HY-14975
Quantity:

R1487 Hydrochloride

Cat. No.: HY-14975