1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase
  3. HIF-2α-IN-1

HIF-2α-IN-1 

Cat. No.: HY-19949 Purity: 99.92%
Handling Instructions

HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay.

For research use only. We do not sell to patients.

HIF-2α-IN-1 Chemical Structure

HIF-2α-IN-1 Chemical Structure

CAS No. : 1799948-06-3

Size Price Stock Quantity
5 mg USD 520 In-stock
Estimated Time of Arrival: December 31
10 mg USD 880 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay. IC50 value: < 500 nM Target: HIF-2α

Molecular Weight

405.30

Formula

C₁₆H₈F₅NO₄S

CAS No.

1799948-06-3

SMILES

N#CC1=CC(F)=CC(OC2=CC=C3C([[email protected]@H](O)C(F)(F)S3(=O)=O)=C2C(F)F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (246.73 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4673 mL 12.3365 mL 24.6731 mL
5 mM 0.4935 mL 2.4673 mL 4.9346 mL
10 mM 0.2467 mL 1.2337 mL 2.4673 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.17 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (6.17 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.17 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.92%

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

HIF-2α-IN-1HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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Product Name:
HIF-2α-IN-1
Cat. No.:
HY-19949
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