1799948-06-3
1799948-06-3
Chemical Structure
HIF-2α-IN-1
- CAS No.: 1799948-06-3
- Formula:C16H8F5NO4S
- Molecular Weight:405.30
IUPAC Name: (R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxido-2,3-dihydrobenzo[b]thiophen-5-yl)oxy)-5-fluorobenzonitrile
InChIKey: HZDKYXAZAPXCKQ-CQSZACIVSA-N
SMILES: N#CC1=CC(F)=CC(OC2=CC=C3C([C@@H](O)C(F)(F)S3(=O)=O)=C2C(F)F)=C1
Biological Activity: HIF-2α-IN-1 (compound 9b) is a HIF-2α inhibitor (IC50=1.7 μM, SPA/scintillation proximity assay)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HIF-2α-IN-1 | 99.94% | HIF-2α-IN-1 (compound 9b) is a HIF-2α inhibitor (IC50=1.7 μM, SPA/scintillation proximity assay). | ||||||||||||||||||||
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References
- [1]. Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385). J Med Chem. 2018 Nov 8;61(21):9691-9721. [Content Brief]
Keywords
