3-Ethoxy-5,6-dibromosalicylaldehyde
3-ethoxy-5,6-dibromosalicylaldehyde is a potent, non-competitive, selective IRE1 (including IRE1α) inhibitor (IC50s: ∼0.12 μM for hIRE1α-cyto; 6 μM for yeast Ire1). 3-ethoxy-5,6-dibromosalicylaldehyde inhibits XBP-1 splicing. 3-ethoxy-5,6-dibromosalicylaldehyde induces Apoptosis. 3-ethoxy-5,6-dibromosalicylaldehyde upregulates the mRNA expression level of TXNIP, while downregulating the expression level of TXN. 3-ethoxy-5,6-dibromosalicylaldehyde exhibits anticancer activity against pancreatic cancer. 3-ethoxy-5,6-dibromosalicylaldehyde significantly inhibits chikungunya virus replication.
For research use only. We do not sell to patients.
- CAS No.: 20041-64-9
- Formula: C9H8Br2O3
- Molecular Weight:323.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50s: ∼0.12 μM for hIRE1α-cyto; 6 μM for yeast Ire1[1]
Chemical Information
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CAS No. 20041-64-9
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Molecular Weight 323.97
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Formula C9H8Br2O3
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SMILES
O=CC1=C(O)C(OCC)=CC(Br)=C1Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Volkmann K, et al. Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J Biol Chem. 2011 Apr 8;286(14):12743-55. [Content Brief]
[2]. Chien W, et al. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget. 2014 Jul 15;5(13):4881-94. [Content Brief]
[3]. Agrawal N, et al. Pharmacological Manipulation of UPR: Potential Antiviral Strategy Against Chikungunya Virus. Indian J Microbiol. 2022 Dec;62(4):634-640. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-Ethoxy-5,6-dibromosalicylaldehyde Related Classifications
HY-123996 Related Classifications
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