20041-64-9
Chemical Structure
3-Ethoxy-5,6-dibromosalicylaldehyde
- CAS No.: 20041-64-9
- Formula:C9H8Br2O3
- Molecular Weight:323.97
IUPAC Name: 2,3-dibromo-5-ethoxy-6-hydroxybenzaldehyde
InChIKey: MZAISYPWQNBWED-UHFFFAOYSA-N
SMILES: O=CC1=C(O)C(OCC)=CC(Br)=C1Br
Biological Activity: 3-ethoxy-5,6-dibromosalicylaldehyde is a potent, non-competitive, selective IRE1 (including IRE1α) inhibitor (IC50s: ∼0.12 μM for hIRE1α-cyto; 6 μM for yeast Ire1). 3-ethoxy-5,6-dibromosalicylaldehyde inhibits XBP-1 splicing. 3-ethoxy-5,6-dibromosalicylaldehyde induces Apoptosis. 3-ethoxy-5,6-dibromosalicylaldehyde upregulates the mRNA expression level of TXNIP, while downregulating the expression level of TXN. 3-ethoxy-5,6-dibromosalicylaldehyde exhibits anticancer activity against pancreatic cancer. 3-ethoxy-5,6-dibromosalicylaldehyde significantly inhibits chikungunya virus replication[1][2][3].
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3-Ethoxy-5,6-dibromosalicylaldehyde | 3-ethoxy-5,6-dibromosalicylaldehyde is a potent, non-competitive, selective IRE1 (including IRE1α) inhibitor (IC50s: ∼0.12 μM for hIRE1α-cyto; 6 μM for yeast Ire1). 3-ethoxy-5,6-dibromosalicylaldehyde inhibits XBP-1 splicing. 3-ethoxy-5,6-dibromosalicylaldehyde induces Apoptosis. 3-ethoxy-5,6-dibromosalicylaldehyde upregulates the mRNA expression level of TXNIP, while downregulating the expression level of TXN. 3-ethoxy-5,6-dibromosalicylaldehyde exhibits anticancer activity against pancreatic cancer. 3-ethoxy-5,6-dibromosalicylaldehyde significantly inhibits chikungunya virus replication. | |||||||||||||||||||||
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- [1]. Volkmann K, et al. Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J Biol Chem. 2011 Apr 8;286(14):12743-55. [Content Brief]
- [2]. Chien W, et al. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget. 2014 Jul 15;5(13):4881-94. [Content Brief]
- [3]. Agrawal N, et al. Pharmacological Manipulation of UPR: Potential Antiviral Strategy Against Chikungunya Virus. Indian J Microbiol. 2022 Dec;62(4):634-640. [Content Brief]
Keywords
