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  3. CU-3

CU-3 

Cat. No.: HY-121638
Handling Instructions

CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells.

For research use only. We do not sell to patients.

CU-3 Chemical Structure

CU-3 Chemical Structure

CAS No. : 861123-84-4

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Description

CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].

Molecular Weight

392.47

Formula

C₁₆H₁₂N₂O₄S₃

CAS No.

861123-84-4

SMILES

O=C1N(C(S/C1=C\C=C\C2=CC=CO2)=S)NS(=O)(C3=CC=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CU-3CU3CU 3ApoptosiscancerapoptosisanergyT cellinterleukin-2DiacylglycerolkinaseDGKimmuneInhibitorinhibitorinhibit

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